Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 99


Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression.

Liao W, Schones DE, Oh J, Cui Y, Cui K, Roh TY, Zhao K, Leonard WJ.

Nat Immunol. 2008 Nov;9(11):1288-96. doi: 10.1038/ni.1656. Epub 2008 Sep 28.


Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.

Liao W, Lin JX, Wang L, Li P, Leonard WJ.

Nat Immunol. 2011 Jun;12(6):551-9. doi: 10.1038/ni.2030. Epub 2011 Apr 24. Erratum in: Nat Immunol. 2011 Jun;12(6): 2 p following 559.


Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo.

Perona-Wright G, Mohrs K, Mayer KD, Mohrs M.

J Immunol. 2010 Jan 15;184(2):615-23. doi: 10.4049/jimmunol.0902408. Epub 2009 Dec 16.


Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection.

Radwanska M, Cutler AJ, Hoving JC, Magez S, Holscher C, Bohms A, Arendse B, Kirsch R, Hunig T, Alexander J, Kaye P, Brombacher F.

PLoS Pathog. 2007 May 11;3(5):e68.


IL-4Ralpha responsiveness of non-CD4 T cells contributes to resistance in schistosoma mansoni infection in pan-T cell-specific IL-4Ralpha-deficient mice.

Dewals B, Hoving JC, Leeto M, Marillier RG, Govender U, Cutler AJ, Horsnell WG, Brombacher F.

Am J Pathol. 2009 Aug;175(2):706-16. doi: 10.2353/ajpath.2009.090137. Epub 2009 Jul 23.


Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells.

Yagi J, Arimura Y, Takatori H, Nakajima H, Iwamoto I, Uchiyama T.

Int Immunol. 2006 Dec;18(12):1681-90. Epub 2006 Oct 11.


Interleukin 2 plays a central role in Th2 differentiation.

Cote-Sierra J, Foucras G, Guo L, Chiodetti L, Young HA, Hu-Li J, Zhu J, Paul WE.

Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3880-5. Epub 2004 Mar 5.


IL-2 regulates expression of C-MAF in human CD4 T cells.

Rani A, Afzali B, Kelly A, Tewolde-Berhan L, Hackett M, Kanhere AS, Pedroza-Pacheco I, Bowen H, Jurcevic S, Jenner RG, Cousins DJ, Ragheb JA, Lavender P, John S.

J Immunol. 2011 Oct 1;187(7):3721-9. doi: 10.4049/jimmunol.1002354. Epub 2011 Aug 29.


An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation.

Stephenson L, Johns MH, Woodward E, Mora AL, Boothby M.

J Immunol. 2004 Oct 1;173(7):4523-8.


IL-4Rα-responsive smooth muscle cells contribute to initiation of TH2 immunity and pulmonary pathology in Nippostrongylus brasiliensis infections.

Horsnell WG, Vira A, Kirstein F, Mearns H, Hoving JC, Cutler AJ, Dewals B, Myburgh E, Kimberg M, Arendse B, White N, Lopata A, Burger PE, Brombacher F.

Mucosal Immunol. 2011 Jan;4(1):83-92. doi: 10.1038/mi.2010.46. Epub 2010 Aug 25.


Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation.

Noben-Trauth N, Hu-Li J, Paul WE.

J Immunol. 2000 Oct 1;165(7):3620-5.


Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation.

Diehl S, Chow CW, Weiss L, Palmetshofer A, Twardzik T, Rounds L, Serfling E, Davis RJ, Anguita J, Rincón M.

J Exp Med. 2002 Jul 1;196(1):39-49.


Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression.

Takatori H, Nakajima H, Kagami S, Hirose K, Suto A, Suzuki K, Kubo M, Yoshimura A, Saito Y, Iwamoto I.

J Immunol. 2005 Apr 1;174(7):4105-12.


The adenosine-dependent angiogenic switch of macrophages to an M2-like phenotype is independent of interleukin-4 receptor alpha (IL-4Rα) signaling.

Ferrante CJ, Pinhal-Enfield G, Elson G, Cronstein BN, Hasko G, Outram S, Leibovich SJ.

Inflammation. 2013 Aug;36(4):921-31. doi: 10.1007/s10753-013-9621-3.


IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation.

Liao W, Lin JX, Leonard WJ.

Curr Opin Immunol. 2011 Oct;23(5):598-604. doi: 10.1016/j.coi.2011.08.003. Epub 2011 Aug 31. Review.


Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection.

Hurdayal R, Nieuwenhuizen NE, Revaz-Breton M, Smith L, Hoving JC, Parihar SP, Reizis B, Brombacher F.

PLoS Pathog. 2013 Oct;9(10):e1003699. doi: 10.1371/journal.ppat.1003699. Epub 2013 Oct 24.


Murine IL-4 is able to signal via chimeric human IL-4Ralpha/mouse gamma-chain receptor.

Myburgh E, Horsnell WG, Cutler AJ, Arendse B, Kubo M, Brombacher F.

Mol Immunol. 2008 Mar;45(5):1327-36. Epub 2007 Oct 29.


Supplemental Content

Support Center