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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM.

Nature. 2008 Dec 4;456(7222):658-62. doi: 10.1038/nature07405. Epub 2008 Sep 28.


UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.

Kim YM, Brinkmann MM, Paquet ME, Ploegh HL.

Nature. 2008 Mar 13;452(7184):234-8. doi: 10.1038/nature06726. Epub 2008 Feb 27.


Regulatory molecules required for nucleotide-sensing Toll-like receptors.

Saitoh S, Miyake K.

Immunol Rev. 2009 Jan;227(1):32-43. doi: 10.1111/j.1600-065X.2008.00729.x. Review.


Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice.

Avalos AM, Kirak O, Oelkers JM, Pils MC, Kim YM, Ottinger M, Jaenisch R, Ploegh HL, Brinkmann MM.

J Immunol. 2013 Jan 15;190(2):695-702. doi: 10.4049/jimmunol.1202342. Epub 2012 Dec 12.


Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells.

Ishii N, Funami K, Tatematsu M, Seya T, Matsumoto M.

J Immunol. 2014 Nov 15;193(10):5118-28. doi: 10.4049/jimmunol.1401375. Epub 2014 Oct 8.


Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.

Ewald SE, Engel A, Lee J, Wang M, Bogyo M, Barton GM.

J Exp Med. 2011 Apr 11;208(4):643-51. doi: 10.1084/jem.20100682. Epub 2011 Mar 14.


Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.

Fukui R, Saitoh S, Matsumoto F, Kozuka-Hata H, Oyama M, Tabeta K, Beutler B, Miyake K.

J Exp Med. 2009 Jun 8;206(6):1339-50. doi: 10.1084/jem.20082316. Epub 2009 May 18.


Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling.

Kim J, Huh J, Hwang M, Kwon EH, Jung DJ, Brinkmann MM, Jang MH, Ploegh HL, Kim YM.

J Immunol. 2013 May 15;190(10):5287-95. doi: 10.4049/jimmunol.1202767. Epub 2013 Apr 12.


Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in an intramolecular disulfide bond, proteolytic cleavage and RNA sensing.

Kanno A, Yamamoto C, Onji M, Fukui R, Saitoh S, Motoi Y, Shibata T, Matsumoto F, Muta T, Miyake K.

Int Immunol. 2013 Jul;25(7):413-22. doi: 10.1093/intimm/dxt007. Epub 2013 Feb 26.


Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.

Fukui R, Saitoh S, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, Miyake K.

Immunity. 2011 Jul 22;35(1):69-81. doi: 10.1016/j.immuni.2011.05.010. Epub 2011 Jun 16.


Heat shock protein gp96 regulates Toll-like receptor 9 proteolytic processing and conformational stability.

Brooks JC, Sun W, Chiosis G, Leifer CA.

Biochem Biophys Res Commun. 2012 May 18;421(4):780-4. doi: 10.1016/j.bbrc.2012.04.083. Epub 2012 Apr 23.


TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA.

Chockalingam A, Brooks JC, Cameron JL, Blum LK, Leifer CA.

Immunol Cell Biol. 2009 Mar-Apr;87(3):209-17. doi: 10.1038/icb.2008.101. Epub 2008 Dec 16.


UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major.

Schamber-Reis BL, Petritus PM, Caetano BC, Martinez ER, Okuda K, Golenbock D, Scott P, Gazzinelli RT.

J Biol Chem. 2013 Mar 8;288(10):7127-36. doi: 10.1074/jbc.M112.407684. Epub 2013 Jan 16.


Regulation of TLR7/9 signaling in plasmacytoid dendritic cells.

Bao M, Liu YJ.

Protein Cell. 2013 Jan;4(1):40-52. doi: 10.1007/s13238-012-2104-8. Epub 2012 Nov 7. Review.


Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation.

Mouchess ML, Arpaia N, Souza G, Barbalat R, Ewald SE, Lau L, Barton GM.

Immunity. 2011 Nov 23;35(5):721-32. doi: 10.1016/j.immuni.2011.10.009. Epub 2011 Nov 10.


The functional effects of physical interactions among Toll-like receptors 7, 8, and 9.

Wang J, Shao Y, Bennett TA, Shankar RA, Wightman PD, Reddy LG.

J Biol Chem. 2006 Dec 8;281(49):37427-34. Epub 2006 Oct 13.


The ectodomain of TLR3 receptor is required for its plasma membrane translocation.

Pohar J, Pirher N, Benčina M, Manček-Keber M, Jerala R.

PLoS One. 2014 Mar 20;9(3):e92391. doi: 10.1371/journal.pone.0092391. eCollection 2014.


An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing.

Onji M, Kanno A, Saitoh S, Fukui R, Motoi Y, Shibata T, Matsumoto F, Lamichhane A, Sato S, Kiyono H, Yamamoto K, Miyake K.

Nat Commun. 2013;4:1949. doi: 10.1038/ncomms2949.


Homology modeling of human Toll-like receptors TLR7, 8, and 9 ligand-binding domains.

Wei T, Gong J, Jamitzky F, Heckl WM, Stark RW, Rössle SC.

Protein Sci. 2009 Aug;18(8):1684-91. doi: 10.1002/pro.186.

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