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Items: 1 to 20 of 98

1.

Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.

Yfanti C, Mengele K, Gkazepis A, Weirich G, Giersig C, Kuo WL, Tang WJ, Rosner M, Schmitt M.

Int J Mol Med. 2008 Oct;22(4):421-31.

2.

Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines.

Weirich G, Mengele K, Yfanti C, Gkazepis A, Hellmann D, Welk A, Giersig C, Kuo WL, Rosner MR, Tang WJ, Schmitt M.

Biol Chem. 2008 Nov;389(11):1441-5. doi: 10.1515/BC.2008.157.

3.

Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels.

Radulescu RT, Hufnagel C, Luppa P, Hellebrand H, Kuo WL, Rosner MR, Harbeck N, Giersig C, Meindl A, Schmitt M, Weirich G.

Int J Oncol. 2007 Jan;30(1):73-80.

PMID:
17143514
4.

Insulin-degrading enzyme is differentially expressed and developmentally regulated in various rat tissues.

Kuo WL, Montag AG, Rosner MR.

Endocrinology. 1993 Feb;132(2):604-11.

PMID:
7678795
5.

Endosomal proteolysis of insulin by an acidic thiol metalloprotease unrelated to insulin degrading enzyme.

Authier F, Rachubinski RA, Posner BI, Bergeron JJ.

J Biol Chem. 1994 Jan 28;269(4):3010-6.

6.

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.

Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ.

J Biol Chem. 1998 Dec 4;273(49):32730-8.

7.

Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.

Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ.

Biochemistry. 2005 May 3;44(17):6513-25.

PMID:
15850385
8.

Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells.

Pivovarova O, Gögebakan O, Pfeiffer AF, Rudovich N.

Diabetologia. 2009 Aug;52(8):1656-64. doi: 10.1007/s00125-009-1350-7.

PMID:
19396426
9.

Insulin-degrading enzyme in a human colon adenocarcinoma cell line (Caco-2).

Bai JP, Hsu MJ, Shier WT.

Pharm Res. 1995 Apr;12(4):513-7.

PMID:
7596985
10.

Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia.

Bernstein HG, Ernst T, Lendeckel U, Bukowska A, Ansorge S, Stauch R, Have ST, Steiner J, Dobrowolny H, Bogerts B.

J Psychiatr Res. 2009 Sep;43(13):1095-105. doi: 10.1016/j.jpsychires.2009.03.006.

PMID:
19394958
11.

Insulin-degrading enzyme (IDE): a novel heat shock-like protein.

Tundo GR, Sbardella D, Ciaccio C, Bianculli A, Orlandi A, Desimio MG, Arcuri G, Coletta M, Marini S.

J Biol Chem. 2013 Jan 25;288(4):2281-9. doi: 10.1074/jbc.M112.393108.

12.

Modulation of insulin degrading enzyme activity and liver cell proliferation.

Pivovarova O, von Loeffelholz C, Ilkavets I, Sticht C, Zhuk S, Murahovschi V, Lukowski S, Döcke S, Kriebel J, de las Heras Gala T, Malashicheva A, Kostareva A, Lock JF, Stockmann M, Grallert H, Gretz N, Dooley S, Pfeiffer AF, Rudovich N.

Cell Cycle. 2015;14(14):2293-300. doi: 10.1080/15384101.2015.1046647.

13.

In vitro degradation of insulin-like peptide 3 by insulin-degrading enzyme.

Zhang WJ, Luo X, Guo ZY.

Protein J. 2010 Feb;29(2):93-8. doi: 10.1007/s10930-009-9226-8.

PMID:
20082125
14.

Natural regulatory mechanisms of insulin degradation by insulin degrading enzyme.

Akiyama H, Yokono K, Shii K, Ogawa W, Taniguchi H, Baba S, Kasuga M.

Biochem Biophys Res Commun. 1990 Aug 16;170(3):1325-30.

PMID:
2202301
15.

Regulation of protein degradation by insulin-degrading enzyme: analysis by small interfering RNA-mediated gene silencing.

Fawcett J, Permana PA, Levy JL, Duckworth WC.

Arch Biochem Biophys. 2007 Dec 1;468(1):128-33. Erratum in: Arch Biochem Biophys. 2008 May 1;473(1):96.

PMID:
17964527
16.

Proteasome Activity Is Affected by Fluctuations in Insulin-Degrading Enzyme Distribution.

Sbardella D, Tundo GR, Sciandra F, Bozzi M, Gioia M, Ciaccio C, Tarantino U, Brancaccio A, Coletta M, Marini S.

PLoS One. 2015 Jul 17;10(7):e0132455. doi: 10.1371/journal.pone.0132455.

17.

Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme.

Çakir B, Dağliyan O, Dağyildiz E, Bariş İ, Kavakli IH, Kizilel S, Türkay M.

PLoS One. 2012;7(2):e31787. doi: 10.1371/journal.pone.0031787.

18.

Functional human insulin-degrading enzyme can be expressed in bacteria.

Chesneau V, Rosner MR.

Protein Expr Purif. 2000 Jun;19(1):91-8.

PMID:
10833395
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