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Items: 1 to 20 of 85

1.

Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform.

Seyb KI, Schuman ER, Ni J, Huang MM, Michaelis ML, Glicksman MA.

J Biomol Screen. 2008 Oct;13(9):870-8. doi: 10.1177/1087057108323909. Epub 2008 Sep 23.

2.

Neuroprotective effect of undecylenic acid extracted from Ricinus communis L. through inhibition of μ-calpain.

Lee E, Eom JE, Kim HL, Kang DH, Jun KY, Jung DS, Kwon Y.

Eur J Pharm Sci. 2012 May 12;46(1-2):17-25. doi: 10.1016/j.ejps.2012.01.015. Epub 2012 Feb 8.

PMID:
22333440
3.

Role of calpain and caspase in beta-amyloid-induced cell death in rat primary septal cultured neurons.

Wei Z, Song MS, MacTavish D, Jhamandas JH, Kar S.

Neuropharmacology. 2008 Mar;54(4):721-33. doi: 10.1016/j.neuropharm.2007.12.006. Epub 2007 Dec 23.

PMID:
18222494
4.

Neuroprotective effects of Mycoplasma hyorhinis against amyloid-β-peptide toxicity in SH-SY5Y human neuroblastoma cells are mediated by calpastatin upregulation in the mycoplasma-infected cells.

Elkind E, Vaisid T, Kornspan JD, Barnoy S, Rottem S, Kosower NS.

Neurochem Int. 2011 Mar;58(4):497-503. doi: 10.1016/j.neuint.2011.01.005. Epub 2011 Jan 8.

PMID:
21219955
5.

A new concept: Aβ1-42 generates a hyperfunctional proteolytic NCX3 fragment that delays caspase-12 activation and neuronal death.

Pannaccione A, Secondo A, Molinaro P, D'Avanzo C, Cantile M, Esposito A, Boscia F, Scorziello A, Sirabella R, Sokolow S, Herchuelz A, Di Renzo G, Annunziato L.

J Neurosci. 2012 Aug 1;32(31):10609-17. doi: 10.1523/JNEUROSCI.6429-11.2012. Erratum in: J Neurosci. 2012 Dec 12;32(50):18269. Sokolow, Sophie [added]; Herchuelz, André [added].

6.

Galantamine inhibits calpain-calcineurin signaling activated by beta-amyloid in human neuroblastoma SH-SY5Y cells.

Li Q, Fang J, Yang M, Wu D, Zhang L, Zhang Y.

Neurosci Lett. 2010 Aug 23;480(3):173-7.

PMID:
20665950
7.

Effect of conjugated linoleic acid, μ-calpain inhibitor, on pathogenesis of Alzheimer's disease.

Lee E, Eom JE, Kim HL, Baek KH, Jun KY, Kim HJ, Lee M, Mook-Jung I, Kwon Y.

Biochim Biophys Acta. 2013 Apr;1831(4):709-18. doi: 10.1016/j.bbalip.2012.12.003. Epub 2012 Dec 14.

PMID:
23246577
8.

BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells.

Jämsä A, Belda O, Edlund M, Lindström E.

J Biomed Sci. 2011 Oct 21;18:76. doi: 10.1186/1423-0127-18-76.

9.

Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma.

Abramova NA, Cassarino DS, Khan SM, Painter TW, Bennett JP Jr.

J Neurosci Res. 2002 Feb 15;67(4):494-500.

PMID:
11835316
10.

Alzheimer's disease.

De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV.

Subcell Biochem. 2012;65:329-52. doi: 10.1007/978-94-007-5416-4_14. Review.

PMID:
23225010
11.

Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology.

Higuchi M, Iwata N, Matsuba Y, Takano J, Suemoto T, Maeda J, Ji B, Ono M, Staufenbiel M, Suhara T, Saido TC.

FASEB J. 2012 Mar;26(3):1204-17. doi: 10.1096/fj.11-187740. Epub 2011 Dec 15.

PMID:
22173972
12.

Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease.

Yahata N, Asai M, Kitaoka S, Takahashi K, Asaka I, Hioki H, Kaneko T, Maruyama K, Saido TC, Nakahata T, Asada T, Yamanaka S, Iwata N, Inoue H.

PLoS One. 2011;6(9):e25788. doi: 10.1371/journal.pone.0025788. Epub 2011 Sep 30.

13.

High-energy compounds mobilize intracellular Ca2+ and activate calpain in cultured cells: is calpain an energy-dependent protease?

Nguyen HT, Chen M.

Brain Res Bull. 2014 Mar;102:9-14. doi: 10.1016/j.brainresbull.2014.01.006. Epub 2014 Feb 5.

PMID:
24508187
14.

Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils.

Hu SQ, Wang R, Cui W, Mak SH, Li G, Hu YJ, Lee MY, Pang YP, Han YF.

CNS Neurosci Ther. 2015 Dec;21(12):953-61. doi: 10.1111/cns.12472. Epub 2015 Oct 28.

PMID:
26507365
15.

Inhibition of amyloid-β aggregation in Alzheimer's disease.

Wang Q, Yu X, Li L, Zheng J.

Curr Pharm Des. 2014;20(8):1223-43. Review.

PMID:
23713775
16.

Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line.

Lu Y, Ansar S, Michaelis ML, Blagg BS.

Bioorg Med Chem. 2009 Feb 15;17(4):1709-15. doi: 10.1016/j.bmc.2008.12.047. Epub 2008 Dec 25.

17.

Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.

Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG.

J Biol Chem. 2010 Sep 3;285(36):27737-44. doi: 10.1074/jbc.M110.117960. Epub 2010 Jul 1.

18.

The molecular bases of Alzheimer's disease and other neurodegenerative disorders.

Maccioni RB, Muñoz JP, Barbeito L.

Arch Med Res. 2001 Sep-Oct;32(5):367-81. Review.

PMID:
11578751
19.

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.

Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM.

J Biol Chem. 2005 Feb 18;280(7):5892-901. Epub 2004 Dec 7.

20.

Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment.

Garg S, Timm T, Mandelkow EM, Mandelkow E, Wang Y.

Neurobiol Aging. 2011 Jan;32(1):1-14. doi: 10.1016/j.neurobiolaging.2010.09.008. Epub 2010 Oct 18.

PMID:
20961659

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