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Items: 1 to 20 of 262

1.

6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors.

Bromidge SM, Bertani B, Borriello M, Faedo S, Gordon LJ, Granci E, Hill M, Marshall HR, Stasi LP, Zucchelli V, Merlo G, Vesentini A, Watson JM, Zonzini L.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5653-6. doi: 10.1016/j.bmcl.2008.08.084. Epub 2008 Aug 28.

PMID:
18799312
2.

Novel 5-HT(1A/1B/1D) receptors antagonists with potent 5-HT reuptake inhibitory activity.

Serafinowska HT, Blaney FE, Lovell PJ, Merlo GG, Scott CM, Smith PW, Starr KR, Watson JM.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5581-5. doi: 10.1016/j.bmcl.2008.08.110. Epub 2008 Sep 3.

PMID:
18829312
3.

Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors.

Bueno AB, Gilmore J, Boot J, Broadmore R, Cooper J, Findlay J, Hayhurst L, Marcos A, Montero C, Mitchell S, Timms G, Tomlinson R, Wallace L, Walton L.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3344-8. Epub 2007 Apr 5.

PMID:
17434731
4.

3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors.

Lovell PJ, Blaney FE, Goodacre CJ, Scott CM, Smith PW, Starr KR, Thewlis KM, Vong AK, Ward SE, Watson JM.

Bioorg Med Chem Lett. 2007 Feb 15;17(4):1033-6. Epub 2006 Nov 15.

PMID:
17129726
5.

SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue.

Scott C, Soffin EM, Hill M, Atkinson PJ, Langmead CJ, Wren PB, Faedo S, Gordon LJ, Price GW, Bromidge S, Johnson CN, Hagan JJ, Watson J.

Eur J Pharmacol. 2006 Apr 24;536(1-2):54-61. Epub 2006 Feb 28.

PMID:
16571351
6.

Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.

Zhou D, Stack GP, Lo J, Failli AA, Evrard DA, Harrison BL, Hatzenbuhler NT, Tran M, Croce S, Yi S, Golembieski J, Hornby GA, Lai M, Lin Q, Schechter LE, Smith DL, Shilling AD, Huselton C, Mitchell P, Beyer CE, Andree TH.

J Med Chem. 2009 Aug 13;52(15):4955-9. doi: 10.1021/jm900374r.

PMID:
19719241
7.

5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants.

Matzen L, van Amsterdam C, Rautenberg W, Greiner HE, Harting J, Seyfried CA, Böttcher H.

J Med Chem. 2000 Mar 23;43(6):1149-57.

PMID:
10737747
8.

8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II.

Bromidge SM, Bertani B, Borriello M, Bozzoli A, Faedo S, Gianotti M, Gordon LJ, Hill M, Zucchelli V, Watson JM, Zonzini L.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2338-42. doi: 10.1016/j.bmcl.2009.02.056. Epub 2009 Feb 20.

PMID:
19286377
10.

Discovery of the first potent, selective 5-hydroxytryptamine1D receptor antagonist.

Ward SE, Harrington FP, Gordon LJ, Hopley SC, Scott CM, Watson JM.

J Med Chem. 2005 May 19;48(10):3478-80.

PMID:
15887956
11.

New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.

Martínez-Esparza J, Oficialdegui AM, Pérez-Silanes S, Heras B, Orús L, Palop JA, Lasheras B, Roca J, Mourelle M, Bosch A, Del Castillo JC, Tordera R, Del Río J, Monge A.

J Med Chem. 2001 Feb 1;44(3):418-28.

PMID:
11462981
12.

Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs.

Kling A, Lange UE, Mack H, Bakker MH, Drescher KU, Hornberger W, Hutchins CW, Möller A, Müller R, Schmidt M, Unger L, Wicke K, Schellhaas K, Steiner G.

Bioorg Med Chem Lett. 2005 Dec 15;15(24):5567-73. Epub 2005 Oct 10.

PMID:
16219465
13.

Effect of combined administration of 5-HT1A or 5-HT1B/1D receptor antagonists and antidepressants in the forced swimming test.

Tatarczyńska E, Kłodzińska A, Stachowicz K, Chojnacka-Wójcik E.

Eur J Pharmacol. 2004 Mar 8;487(1-3):133-42.

PMID:
15033385
14.
15.

Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists.

Ward SE, Eddershaw PJ, Scott CM, Gordon LJ, Lovell PJ, Moore SH, Smith PW, Starr KR, Thewlis KM, Watson JM.

J Med Chem. 2008 May 22;51(10):2887-90. doi: 10.1021/jm8001444. Epub 2008 Apr 24.

PMID:
18433113
16.

Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism.

Oficialdegui AM, Martinez J, Pérez S, Heras B, Irurzun M, Palop JA, Tordera R, Lasheras B, del Río J, Monge A.

Farmaco. 2000 May;55(5):345-53.

PMID:
10983279
17.

Novel selective and potent 5-HT reuptake inhibitors with 5-HT1D antagonist activity: chemistry and pharmacological evaluation of a series of thienopyran derivatives.

Torrado A, Lamas C, Agejas J, Jiménez A, Diaz N, Gilmore J, Boot J, Findlay J, Hayhurst L, Wallace L, Broadmore R, Tomlinson R.

Bioorg Med Chem. 2004 Oct 15;12(20):5277-95.

PMID:
15388156
18.

Structure-activity relationship studies of CNS agents. Part 38. Novel 1,4-benzoxazin-3(4H)-one, 1,2-benzoxazolin-3-one and 1,3-benzoxazolin-2,4-dione arylpiperazine derivatives with different 5-HT1A and antagonistic 5-HT2A activities.

Mokrosz MJ, Kowalski P, Kowalska T, Majka Z, Duszyńska B, Bojarski AJ, Fruziński A, Karolak-Wojciechowska J, Wesołowska A, Kłodzińska A, Tatarczyńska E, Chojnacka-Wójcik E.

Arch Pharm (Weinheim). 1999 Nov;332(11):373-9.

PMID:
10605377
19.
20.

New 3-[4-(aryl)piperazin-1-yl]-1-(benzo[b]thiophen-3-yl)propane derivatives with dual action at 5-HT1A serotonin receptors and serotonin transporter as a new class of antidepressants.

Martínez J, Pérez S, Oficialdegui AM, Heras B, Orús L, Villanueva H, Palop JA, Roca J, Mourelle M, Bosch A, Del Castillo JC, Lasheras B, Tordera R, del Río J, Monge A.

Eur J Med Chem. 2001 Jan;36(1):55-61.

PMID:
11231049

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