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Items: 1 to 20 of 127

1.

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla.

McLellan JS, Zheng X, Hauk G, Ghirlando R, Beachy PA, Leahy DJ.

Nature. 2008 Oct 16;455(7215):979-83. doi: 10.1038/nature07358. Epub 2008 Sep 14.

2.

All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.

Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ.

J Biol Chem. 2010 Aug 6;285(32):24584-90. doi: 10.1074/jbc.M110.131680. Epub 2010 Jun 1.

3.

Structure of a heparin-dependent complex of Hedgehog and Ihog.

McLellan JS, Yao S, Zheng X, Geisbrecht BV, Ghirlando R, Beachy PA, Leahy DJ.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17208-13. Epub 2006 Oct 31.

4.

The ihog cell-surface proteins bind Hedgehog and mediate pathway activation.

Yao S, Lum L, Beachy P.

Cell. 2006 Apr 21;125(2):343-57.

5.

The Drosophila WIF1 homolog Shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi.

Avanesov A, Blair SS.

Development. 2013 Jan 1;140(1):107-16. doi: 10.1242/dev.078444. Epub 2012 Nov 15.

6.

Cdon and Boc: Two transmembrane proteins implicated in cell-cell communication.

Sanchez-Arrones L, Cardozo M, Nieto-Lopez F, Bovolenta P.

Int J Biochem Cell Biol. 2012 May;44(5):698-702. doi: 10.1016/j.biocel.2012.01.019. Epub 2012 Feb 3. Review.

PMID:
22326621
7.

Interactions between Hedgehog proteins and their binding partners come into view.

Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C.

Genes Dev. 2010 Sep 15;24(18):2001-12. doi: 10.1101/gad.1951710. Review.

8.

Ihog and Boi are essential for Hedgehog signaling in Drosophila.

Camp D, Currie K, Labbé A, van Meyel DJ, Charron F.

Neural Dev. 2010 Nov 2;5:28. doi: 10.1186/1749-8104-5-28.

9.

Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors.

Bae GU, Domené S, Roessler E, Schachter K, Kang JS, Muenke M, Krauss RS.

Am J Hum Genet. 2011 Aug 12;89(2):231-40. doi: 10.1016/j.ajhg.2011.07.001. Epub 2011 Jul 28.

10.

Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand.

Camp D, Haitian He B, Li S, Althaus IW, Holtz AM, Allen BL, Charron F, van Meyel DJ.

Development. 2014 Oct;141(20):3879-88. doi: 10.1242/dev.103564. Epub 2014 Sep 17.

11.

Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway.

Zhang F, McLellan JS, Ayala AM, Leahy DJ, Linhardt RJ.

Biochemistry. 2007 Apr 3;46(13):3933-41. Epub 2007 Mar 10.

12.

Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation.

Izzi L, Lévesque M, Morin S, Laniel D, Wilkes BC, Mille F, Krauss RS, McMahon AP, Allen BL, Charron F.

Dev Cell. 2011 Jun 14;20(6):788-801. doi: 10.1016/j.devcel.2011.04.017.

13.

Boc modifies the holoprosencephaly spectrum of Cdo mutant mice.

Zhang W, Hong M, Bae GU, Kang JS, Krauss RS.

Dis Model Mech. 2011 May;4(3):368-80. doi: 10.1242/dmm.005744. Epub 2010 Dec 23.

14.

Genetic and biochemical definition of the Hedgehog receptor.

Zheng X, Mann RK, Sever N, Beachy PA.

Genes Dev. 2010 Jan 1;24(1):57-71. doi: 10.1101/gad.1870310.

15.

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.

Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS, McMahon AP.

Dev Cell. 2006 May;10(5):647-56. Epub 2006 Apr 27.

16.

Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif.

Bilioni A, Sánchez-Hernández D, Callejo A, Gradilla AC, Ibáñez C, Mollica E, Carmen Rodríguez-Navas M, Simon E, Guerrero I.

Dev Biol. 2013 Apr 15;376(2):198-212. doi: 10.1016/j.ydbio.2012.12.013. Epub 2012 Dec 29.

17.

Drosophila miR-932 modulates hedgehog signaling by targeting its co-receptor Brother of ihog.

Gao L, Wu L, Hou X, Zhang Q, Zhang F, Ye X, Yang Y, Lin X.

Dev Biol. 2013 May 1;377(1):166-76. doi: 10.1016/j.ydbio.2013.02.002. Epub 2013 Feb 21.

18.

Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction.

Shi D, Lv X, Zhang Z, Yang X, Zhou Z, Zhang L, Zhao Y.

J Biol Chem. 2013 May 3;288(18):12605-14. doi: 10.1074/jbc.M112.399477. Epub 2013 Mar 26.

19.

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

Bishop B, Aricescu AR, Harlos K, O'Callaghan CA, Jones EY, Siebold C.

Nat Struct Mol Biol. 2009 Jul;16(7):698-703. doi: 10.1038/nsmb.1607. Epub 2009 Jun 28.

20.

Sonic hedgehog signaling by the patched-smoothened receptor complex.

Murone M, Rosenthal A, de Sauvage FJ.

Curr Biol. 1999 Jan 28;9(2):76-84.

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