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Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines.

Lopes EC, Valls E, Figueroa ME, Mazur A, Meng FG, Chiosis G, Laird PW, Schreiber-Agus N, Greally JM, Prokhortchouk E, Melnick A.

Cancer Res. 2008 Sep 15;68(18):7258-63. doi: 10.1158/0008-5472.CAN-08-0344.


Epigenetic inactivation of T-box transcription factor 5, a novel tumor suppressor gene, is associated with colon cancer.

Yu J, Ma X, Cheung KF, Li X, Tian L, Wang S, Wu CW, Wu WK, He M, Wang M, Ng SS, Sung JJ.

Oncogene. 2010 Dec 9;29(49):6464-74. doi: 10.1038/onc.2010.370. Epub 2010 Aug 30.


Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM, Jones PA.

Cancer Res. 1995 Oct 15;55(20):4531-5.


Kaiso represses the cell cycle gene cyclin D1 via sequence-specific and methyl-CpG-dependent mechanisms.

Donaldson NS, Pierre CC, Anstey MI, Robinson SC, Weerawardane SM, Daniel JM.

PLoS One. 2012;7(11):e50398. doi: 10.1371/journal.pone.0050398. Epub 2012 Nov 30.


MBD2-mediated transcriptional repression of the p14ARF tumor suppressor gene in human colon cancer cells.

Martin V, Jørgensen HF, Chaubert AS, Berger J, Barr H, Shaw P, Bird A, Chaubert P.

Pathobiology. 2008;75(5):281-7. doi: 10.1159/000151708. Epub 2008 Oct 15.


Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia.

Magdinier F, Wolffe AP.

Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):4990-5. Epub 2001 Apr 17.


Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model.

Borinstein SC, Conerly M, Dzieciatkowski S, Biswas S, Washington MK, Trobridge P, Henikoff S, Grady WM.

Mol Carcinog. 2010 Jan;49(1):94-103. doi: 10.1002/mc.20581.


FHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect.

Asada K, Ando T, Niwa T, Nanjo S, Watanabe N, Okochi-Takada E, Yoshida T, Miyamoto K, Enomoto S, Ichinose M, Tsukamoto T, Ito S, Tatematsu M, Sugiyama T, Ushijima T.

Oncogene. 2013 Apr 25;32(17):2140-9. doi: 10.1038/onc.2012.228. Epub 2012 Jun 11.


Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer.

Kriegl L, Neumann J, Vieth M, Greten FR, Reu S, Jung A, Kirchner T.

Mod Pathol. 2011 Jul;24(7):1015-22. doi: 10.1038/modpathol.2011.43. Epub 2011 Mar 18.


KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes.

Koh DI, Han D, Ryu H, Choi WI, Jeon BN, Kim MK, Kim Y, Kim JY, Parry L, Clarke AR, Reynolds AB, Hur MW.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15078-83. doi: 10.1073/pnas.1318780111. Epub 2014 Oct 6.


DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2.

McGarvey KM, Greene E, Fahrner JA, Jenuwein T, Baylin SB.

Cancer Res. 2007 Jun 1;67(11):5097-102.


Frequent epigenetic silencing of the CpG island promoter of RASSF1A in thyroid carcinoma.

Schagdarsurengin U, Gimm O, Hoang-Vu C, Dralle H, Pfeifer GP, Dammann R.

Cancer Res. 2002 Jul 1;62(13):3698-701.


The p16-specific reactivation and inhibition of cell migration through demethylation of CpG islands by engineered transcription factors.

Zhang B, Xiang S, Zhong Q, Yin Y, Gu L, Deng D.

Hum Gene Ther. 2012 Oct;23(10):1071-81. doi: 10.1089/hum.2012.070. Epub 2012 Aug 27.


DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers.

Ying J, Poon FF, Yu J, Geng H, Wong AH, Qiu GH, Goh HK, Rha SY, Tian L, Chan AT, Sung JJ, Tao Q.

Br J Cancer. 2009 Feb 24;100(4):663-9. doi: 10.1038/sj.bjc.6604888. Epub 2009 Jan 20.


Id1 overexpression is independent of repression and epigenetic silencing of tumor suppressor genes in melanoma.

Healey MA, Deaton SL, Alder JK, Winnepenninckx V, Casero RA Jr, Herman JG.

Epigenetics. 2010 Jul 1;5(5):410-21. Epub 2010 Jul 1.


Synergism between DNA methylation and macroH2A1 occupancy in epigenetic silencing of the tumor suppressor gene p16(CDKN2A).

Barzily-Rokni M, Friedman N, Ron-Bigger S, Isaac S, Michlin D, Eden A.

Nucleic Acids Res. 2011 Mar;39(4):1326-35. doi: 10.1093/nar/gkq994. Epub 2010 Oct 28.


Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features.

Lin SY, Yeh KT, Chen WT, Chen HC, Chen ST, Chiou HY, Chang JG.

Oncol Rep. 2004 Feb;11(2):341-8.


Inactivation of Adenomatous Polyposis Coli Reduces Bile Acid/Farnesoid X Receptor Expression through Fxr gene CpG Methylation in Mouse Colon Tumors and Human Colon Cancer Cells.

Selmin OI, Fang C, Lyon AM, Doetschman TC, Thompson PA, Martinez JD, Smith JW, Lance PM, Romagnolo DF.

J Nutr. 2016 Feb;146(2):236-42. doi: 10.3945/jn.115.216580. Epub 2015 Nov 25.


High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma.

Zhang YJ, Ahsan H, Chen Y, Lunn RM, Wang LY, Chen SY, Lee PH, Chen CJ, Santella RM.

Mol Carcinog. 2002 Oct;35(2):85-92.


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