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Items: 1 to 20 of 241

1.

Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators.

Lum RT, Cheng M, Cristobal CP, Goldfine ID, Evans JL, Keck JG, Macsata RW, Manchem VP, Matsumoto Y, Park SJ, Rao SS, Robinson L, Shi S, Spevak WR, Schow SR.

J Med Chem. 2008 Oct 9;51(19):6173-87. doi: 10.1021/jm800600v. Epub 2008 Sep 13.

PMID:
18788731
2.

Regulation of insulin receptor function by a small molecule insulin receptor activator.

Pender C, Goldfine ID, Manchem VP, Evans JL, Spevak WR, Shi S, Rao S, Bajjalieh S, Maddux BA, Youngren JF.

J Biol Chem. 2002 Nov 15;277(46):43565-71. Epub 2002 Sep 3.

3.

Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators.

Qureshi SA, Ding V, Li Z, Szalkowski D, Biazzo-Ashnault DE, Xie D, Saperstein R, Brady E, Huskey S, Shen X, Liu K, Xu L, Salituro GM, Heck JV, Moller DE, Jones AB, Zhang BB.

J Biol Chem. 2000 Nov 24;275(47):36590-5.

4.

5-Substituted isophthalamides as insulin receptor sensitizers.

Robinson L, Bajjalieh S, Cairns N, Lum RT, Macsata RW, Manchem VP, Park SJ, Rao S, Schow SR, Shi S, Spevak WR.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3492-4. doi: 10.1016/j.bmcl.2008.05.031. Epub 2008 May 15.

PMID:
18513965
5.

Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor.

Liu K, Xu L, Szalkowski D, Li Z, Ding V, Kwei G, Huskey S, Moller DE, Heck JV, Zhang BB, Jones AB.

J Med Chem. 2000 Sep 21;43(19):3487-94.

PMID:
11000003
6.

Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity.

Martin MW, Newcomb J, Nunes JJ, Boucher C, Chai L, Epstein LF, Faust T, Flores S, Gallant P, Gore A, Gu Y, Hsieh F, Huang X, Kim JL, Middleton S, Morgenstern K, Oliveira-dos-Santos A, Patel VF, Powers D, Rose P, Tudor Y, Turci SM, Welcher AA, Zack D, Zhao H, Zhu L, Zhu X, Ghiron C, Ermann M, Johnston D, Saluste CG.

J Med Chem. 2008 Mar 27;51(6):1637-48. doi: 10.1021/jm701095m. Epub 2008 Feb 16.

PMID:
18278858
7.

Discovery of a small molecule insulin mimetic with antidiabetic activity in mice.

Zhang B, Salituro G, Szalkowski D, Li Z, Zhang Y, Royo I, Vilella D, Díez MT, Pelaez F, Ruby C, Kendall RL, Mao X, Griffin P, Calaycay J, Zierath JR, Heck JV, Smith RG, Moller DE.

Science. 1999 May 7;284(5416):974-7.

8.

Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.

Harmange JC, Weiss MM, Germain J, Polverino AJ, Borg G, Bready J, Chen D, Choquette D, Coxon A, DeMelfi T, DiPietro L, Doerr N, Estrada J, Flynn J, Graceffa RF, Harriman SP, Kaufman S, La DS, Long A, Martin MW, Neervannan S, Patel VF, Potashman M, Regal K, Roveto PM, Schrag ML, Starnes C, Tasker A, Teffera Y, Wang L, White RD, Whittington DA, Zanon R.

J Med Chem. 2008 Mar 27;51(6):1649-67. doi: 10.1021/jm701097z. Epub 2008 Mar 7.

PMID:
18324761
9.

In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator.

Cheng M, Chen S, Schow SR, Manchem VP, Spevak WR, Cristobal CP, Shi S, Macsata RW, Lum RT, Goldfine ID, Keck JG.

J Cell Biochem. 2004 Aug 15;92(6):1234-45.

PMID:
15258906
10.

Insulin-sensitizing activities of tanshinones, diterpene compounds of the root of Salvia miltiorrhiza Bunge.

Jung SH, Seol HJ, Jeon SJ, Son KH, Lee JR.

Phytomedicine. 2009 Apr;16(4):327-35. doi: 10.1016/j.phymed.2008.12.017. Epub 2009 Feb 5.

PMID:
19200697
11.

Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.

Matthews JM, Chen X, Cryan E, Hlasta DJ, Rybczynski PJ, Strauss K, Tang Y, Xu JZ, Yang M, Zhou L, Demarest KT.

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6773-8. Epub 2007 Oct 17.

PMID:
18029176
12.

Synthesis and blood glucose lowering effect of novel pyridazinone substituted benzenesulfonylurea derivatives.

Rathish IG, Javed K, Bano S, Ahmad S, Alam MS, Pillai KK.

Eur J Med Chem. 2009 Jun;44(6):2673-8. doi: 10.1016/j.ejmech.2008.12.013. Epub 2008 Dec 24.

PMID:
19171410
13.

Fibroin-derived peptides stimulate glucose transport in normal and insulin-resistant 3T3-L1 adipocytes.

Kim ED, Bayaraa T, Shin EJ, Hyun CK.

Biol Pharm Bull. 2009 Mar;32(3):427-33.

14.

Design, synthesis, and biological activity of potent and orally available G protein-coupled receptor 40 agonists.

Sasaki S, Kitamura S, Negoro N, Suzuki M, Tsujihata Y, Suzuki N, Santou T, Kanzaki N, Harada M, Tanaka Y, Kobayashi M, Tada N, Funami M, Tanaka T, Yamamoto Y, Fukatsu K, Yasuma T, Momose Y.

J Med Chem. 2011 Mar 10;54(5):1365-78. doi: 10.1021/jm101405t. Epub 2011 Feb 14.

PMID:
21319751
15.

Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor.

Wood ER, Shewchuk L, Hassel A, Nichols J, Truesdale AT, Smith D, Carter HL, Weaver K, Barrett G, Leesnitzer T, Alvarez E, Bardera AI, Alamillo A, Cantizani J, Martin J, Smith GK, Jensen DE, Xie H, Mook R, Kumar R, Kuntz K.

Biochem Pharmacol. 2009 Dec 15;78(12):1438-47. doi: 10.1016/j.bcp.2009.07.022. Epub 2009 Aug 7.

PMID:
19665448
16.

High-throughput synthesis optimization of sulfonamide NPY Y5 antagonists.

Finn J, Pelham D, Walker MW, Gluchowski C.

Bioorg Med Chem Lett. 2002 Jul 8;12(13):1771-4.

PMID:
12067558
17.

18F9 (4-(3,6-bis (ethoxycarbonyl)-4,5,6,7-tetrahydrothieno (2,3-c) pyridin-2-ylamino)-4-oxobutanoic acid) enhances insulin-mediated glucose uptake in vitro and exhibits antidiabetic activity in vivo in db/db mice.

Anandharajan R, Sayyed SG, Doshi LS, Dixit P, Chandak PG, Dixit AV, Brahma MK, Deshmukh NJ, Gupte R, Damre A, Suthar J, Padigaru M, Sharma SD, Nemmani KV.

Metabolism. 2009 Oct;58(10):1503-16. doi: 10.1016/j.metabol.2009.04.036. Epub 2009 Jul 15.

18.

INT131: a selective modulator of PPAR gamma.

Motani A, Wang Z, Weiszmann J, McGee LR, Lee G, Liu Q, Staunton J, Fang Z, Fuentes H, Lindstrom M, Liu J, Biermann DH, Jaen J, Walker NP, Learned RM, Chen JL, Li Y.

J Mol Biol. 2009 Mar 13;386(5):1301-11.

PMID:
19452630
19.

Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.

Uehling DE, Donaldson KH, Deaton DN, Hyman CE, Sugg EE, Barrett DG, Hughes RG, Reitter B, Adkison KK, Lancaster ME, Lee F, Hart R, Paulik MA, Sherman BW, True T, Cowan C.

J Med Chem. 2002 Jan 31;45(3):567-83.

PMID:
11806709
20.

N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands.

Rivara S, Lodola A, Mor M, Bedini A, Spadoni G, Lucini V, Pannacci M, Fraschini F, Scaglione F, Sanchez RO, Gobbi G, Tarzia G.

J Med Chem. 2007 Dec 27;50(26):6618-26. Epub 2007 Dec 6.

PMID:
18052314

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