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Items: 1 to 20 of 103

1.

p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease.

Wetzel MK, Naska S, Laliberté CL, Rymar VV, Fujitani M, Biernaskie JA, Cole CJ, Lerch JP, Spring S, Wang SH, Frankland PW, Henkelman RM, Josselyn SA, Sadikot AF, Miller FD, Kaplan DR.

Neuron. 2008 Sep 11;59(5):708-21. doi: 10.1016/j.neuron.2008.07.021.

2.

p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.

Cancino GI, Miller FD, Kaplan DR.

Neurobiol Aging. 2013 Feb;34(2):387-99. doi: 10.1016/j.neurobiolaging.2012.04.010. Epub 2012 May 15.

PMID:
22592019
3.

No more brain tangles with DeltaNp73.

Mattson MP, Ashery U.

Trends Biochem Sci. 2009 Jan;34(1):6-8. doi: 10.1016/j.tibs.2008.10.004. Epub 2008 Nov 13. Review.

4.

STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits.

Cancino GI, Toledo EM, Leal NR, Hernandez DE, Yévenes LF, Inestrosa NC, Alvarez AR.

Brain. 2008 Sep;131(Pt 9):2425-42. doi: 10.1093/brain/awn125. Epub 2008 Jun 17.

PMID:
18559370
5.

Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.

Caccamo A, Branca C, Talboom JS, Shaw DM, Turner D, Ma L, Messina A, Huang Z, Wu J, Oddo S.

J Neurosci. 2015 Oct 14;35(41):14042-56. doi: 10.1523/JNEUROSCI.2781-15.2015.

6.

Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts.

Vardarajan B, Vergote D, Tissir F, Logue M, Yang J, Daude N, Ando K, Rogaeva E, Lee J, Cheng R, Brion JP, Ghani M, Shi B, Baldwin CT, Kar S, Mayeux R, Fraser P, Goffinet AM, George-Hyslop PS, Farrer LA, Westaway D.

Mol Neurodegener. 2013 Feb 15;8:10. doi: 10.1186/1750-1326-8-10.

7.

Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology.

Isopi E, Granzotto A, Corona C, Bomba M, Ciavardelli D, Curcio M, Canzoniero LM, Navarra R, Lattanzio R, Piantelli M, Sensi SL.

Neurobiol Dis. 2015 Sep;81:214-24. doi: 10.1016/j.nbd.2014.11.013. Epub 2014 Nov 28.

PMID:
25434488
8.

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.

Kocherhans S, Madhusudan A, Doehner J, Breu KS, Nitsch RM, Fritschy JM, Knuesel I.

J Neurosci. 2010 Jul 7;30(27):9228-40. doi: 10.1523/JNEUROSCI.0418-10.2010.

9.

Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin.

Ma QL, Yang F, Rosario ER, Ubeda OJ, Beech W, Gant DJ, Chen PP, Hudspeth B, Chen C, Zhao Y, Vinters HV, Frautschy SA, Cole GM.

J Neurosci. 2009 Jul 15;29(28):9078-89. doi: 10.1523/JNEUROSCI.1071-09.2009.

10.

Truncated tau at D421 is associated with neurodegeneration and tangle formation in the brain of Alzheimer transgenic models.

Zhang Q, Zhang X, Sun A.

Acta Neuropathol. 2009 Jun;117(6):687-97. doi: 10.1007/s00401-009-0491-6. Epub 2009 Feb 4.

PMID:
19190923
11.

Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons.

Padmanabhan J, Levy M, Dickson DW, Potter H.

Brain. 2006 Nov;129(Pt 11):3020-34. Epub 2006 Sep 20.

PMID:
16987932
12.

Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease.

Rothman SM, Herdener N, Frankola KA, Mughal MR, Mattson MP.

Brain Res. 2013 Sep 5;1529:200-8. doi: 10.1016/j.brainres.2013.07.010. Epub 2013 Jul 13.

13.

Transgenic mice as a model of pre-clinical Alzheimer's disease.

Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC.

Curr Alzheimer Res. 2011 Feb;8(1):4-23.

PMID:
21143159
14.

SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.

Capsoni S, Carlo AS, Vignone D, Amato G, Criscuolo C, Willnow TE, Cattaneo A.

J Alzheimers Dis. 2013;33(2):357-71. doi: 10.3233/JAD-2012-121399.

PMID:
22986780
15.

Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse.

Chen Q, Nakajima A, Choi SH, Xiong X, Tang YP.

J Neurosci Res. 2008 May 15;86(7):1615-25. doi: 10.1002/jnr.21601.

PMID:
18189321
16.

Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.

Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM.

J Neurosci. 2010 May 26;30(21):7281-9. doi: 10.1523/JNEUROSCI.0490-10.2010.

17.

Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease.

Saul A, Sprenger F, Bayer TA, Wirths O.

Neurobiol Aging. 2013 Nov;34(11):2564-73. doi: 10.1016/j.neurobiolaging.2013.05.003. Epub 2013 Jun 5.

PMID:
23747045
18.

Fyn knock-down increases Aβ, decreases phospho-tau, and worsens spatial learning in 3×Tg-AD mice.

Minami SS, Clifford TG, Hoe HS, Matsuoka Y, Rebeck GW.

Neurobiol Aging. 2012 Apr;33(4):825.e15-24. doi: 10.1016/j.neurobiolaging.2011.05.014. Epub 2011 Jul 7.

19.

SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease.

Hong Y, Chan CB, Kwon IS, Li X, Song M, Lee HP, Liu X, Sompol P, Jin P, Lee HG, Yu SP, Ye K.

J Neurosci. 2012 Nov 28;32(48):17262-72. doi: 10.1523/JNEUROSCI.3300-12.2012.

20.

Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment.

McAllister C, Long J, Bowers A, Walker A, Cao P, Honda S, Harada N, Staufenbiel M, Shen Y, Li R.

J Neurosci. 2010 May 26;30(21):7326-34. doi: 10.1523/JNEUROSCI.1180-10.2010.

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