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Items: 1 to 20 of 92

1.

Synthesis and study of 9-deazaguanosine derivatives as potential inhibitors of RNA virus replication.

Hamann M, Pierra C, Storer R, Sommadossi JP, Loi AG, Cadeddu A, Fanti M, Boscu N, Bassetti F, Liuzzi M, Gosselin G.

Nucleic Acids Symp Ser (Oxf). 2008;(52):603-4. doi: 10.1093/nass/nrn305.

2.

Synthesis of halogen-substituted 3-deazaadenosine and 3-deazaguanosine analogues as potential antitumor/antiviral agents.

Liu MC, Luo MZ, Mozdziesz DE, Lin TS, Dutschman GE, Gullen EA, Cheng YC, Sartorelli AC.

Nucleosides Nucleotides Nucleic Acids. 2001 Dec;20(12):1975-2000.

PMID:
11794802
3.

(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity.

Qiu YL, Ksebati MB, Ptak RG, Fan BY, Breitenbach JM, Lin JS, Cheng YC, Kern ER, Drach JC, Zemlicka J.

J Med Chem. 1998 Jan 1;41(1):10-23.

PMID:
9438017
4.

Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.

Chun BK, Wang P, Hassan A, Du J, Tharnish PM, Murakami E, Stuyver L, Otto MJ, Schinazi RF, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2007;26(1):83-97.

PMID:
17162589
5.

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.

Clark JL, Mason JC, Hollecker L, Stuyver LJ, Tharnish PM, McBrayer TR, Otto MJ, Furman PA, Schinazi RF, Watanabe KA.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1712-5.

PMID:
16368235
6.

Synthesis and antiviral evaluation of 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives.

Leroy F, Chaves D, Dukhan D, Storer R, Sommadossi JP, Loi AG, Cadeddu A, Fanti M, Boscu N, Bassetti F, Liuzzi M, Gosselin G.

Nucleic Acids Symp Ser (Oxf). 2008;(52):595-6. doi: 10.1093/nass/nrn301.

7.

Synthesis and antiviral evaluation of 4-fluoropyrazole-3-carboxamide nucleoside derivatives.

Leroy F, Chaves D, Dukhan D, Storer R, Sommadossi JP, Loi AG, Cadeddu A, Fanti M, Boscu N, Bassetti F, Liuzzi M, Gosselin G.

Nucleic Acids Symp Ser (Oxf). 2008;(52):617-8. doi: 10.1093/nass/nrn312.

8.

Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.

McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, Vernachio J, Hutchins J, Ames B, Bryant KD, Gorovits E, Ganguly B, Hunley D, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters R, Wang J, Chamberlain S, Henson G.

J Med Chem. 2010 Jul 8;53(13):4949-57. doi: 10.1021/jm1003792.

PMID:
20527890
9.

The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.

Smith DB, Kalayanov G, Sund C, Winqvist A, Pinho P, Maltseva T, Morisson V, Leveque V, Rajyaguru S, Le Pogam S, Najera I, Benkestock K, Zhou XX, Maag H, Cammack N, Martin JA, Swallow S, Johansson NG, Klumpp K, Smith M.

J Med Chem. 2009 Jan 8;52(1):219-23. doi: 10.1021/jm800981y.

PMID:
19055482
10.

Synthesis and anti-HCV evaluation of 4'(alpha)-ethyl and 2'(beta)-methyl-carbodine analogues.

Li H, Yoo JC, Hong JH.

Nucleosides Nucleotides Nucleic Acids. 2009 Sep;28(9):809-20. doi: 10.1080/15257770903170294.

PMID:
20183620
11.

Synthesis and biological evaluation of 5R- and 5S-methyl substituted D- and L-configuration 1,3-dioxolane nucleoside analogs.

Bera S, Malik L, Bhat B, Carroll SS, Hrin R, MacCoss M, McMasters DR, Miller MD, Moyer G, Olsen DB, Schleif WA, Tomassini JE, Eldrup AB.

Bioorg Med Chem. 2004 Dec 1;12(23):6237-47.

PMID:
15519166
12.

Synthesis and antiviral effects of 2-heteroaryl substituted adenosine and 8-heteroaryl substituted guanosine derivatives.

Persson T, Gronowitz S, Hörnfeldt AB, Johansson NG.

Bioorg Med Chem. 1995 Oct;3(10):1377-82.

PMID:
8564404
13.

The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.

McGuigan C, Perrone P, Madela K, Neyts J.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4316-20. doi: 10.1016/j.bmcl.2009.05.122.

PMID:
19523820
14.

Synthesis and antiviral activity of novel derivatives of 2'-beta-C-methylcytidine.

Fogt J, Januszczyk P, Framski G, Onishi T, Izawa K, De Clercq E, Neyts J, Boryski J.

Nucleic Acids Symp Ser (Oxf). 2008;(52):605-6. doi: 10.1093/nass/nrn306.

15.

Synthesis and antiviral/antitumor activities of certain 3-deazaguanine nucleosides and nucleotides.

Revankar GR, Gupta PK, Adams AD, Dalley NK, McKernan PA, Cook PD, Canonico PG, Robins RK.

J Med Chem. 1984 Nov;27(11):1389-96.

PMID:
6092634
16.

Synthesis of 5-aza-7-deazaguanine nucleoside derivatives as potential anti-flavivirus agents.

Dukhan D, Leroy F, Peyronnet J, Bosc E, Chaves D, Durka M, Storer R, La Colla P, Seela F, Gosselin G.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):671-4.

PMID:
16248011
17.

Stereoselective synthesis and biological evaluations of novel 3'-deoxy-4'-azaribonucleosides as inhibitors of hepatitis C virus RNA replication.

Chiacchio U, Borrello L, Crispino L, Rescifina A, Merino P, Macchi B, Balestrieri E, Mastino A, Piperno A, Romeo G.

J Med Chem. 2009 Jul 9;52(13):4054-7. doi: 10.1021/jm900197j.

PMID:
19419173
18.

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

Clark JL, Hollecker L, Mason JC, Stuyver LJ, Tharnish PM, Lostia S, McBrayer TR, Schinazi RF, Watanabe KA, Otto MJ, Furman PA, Stec WJ, Patterson SE, Pankiewicz KW.

J Med Chem. 2005 Aug 25;48(17):5504-8.

PMID:
16107149
19.

Synthesis and evaluation of optically pure dioxolanes as inhibitors of hepatitis C virus RNA replication.

Bera S, Malik L, Bhat B, Carroll SS, MacCoss M, Olsen DB, Tomassini JE, Eldrup AB.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4455-8.

PMID:
14643345
20.

5'-Homoneplanocin A inhibits hepatitis B and hepatitis C.

Yang M, Schneller SW, Korba B.

J Med Chem. 2005 Jul 28;48(15):5043-6.

PMID:
16033283
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