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Items: 1 to 20 of 74

1.

Ad-MDA-7; INGN 241: a review of preclinical and clinical experience.

Eager R, Harle L, Nemunaitis J.

Expert Opin Biol Ther. 2008 Oct;8(10):1633-43. doi: 10.1517/14712598.8.10.1633 . Review.

PMID:
18774929
2.

Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients.

Tong AW, Nemunaitis J, Su D, Zhang Y, Cunningham C, Senzer N, Netto G, Rich D, Mhashilkar A, Parker K, Coffee K, Ramesh R, Ekmekcioglu S, Grimm EA, van Wart Hood J, Merritt J, Chada S.

Mol Ther. 2005 Jan;11(1):160-72.

3.

Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study.

Cunningham CC, Chada S, Merritt JA, Tong A, Senzer N, Zhang Y, Mhashilkar A, Parker K, Vukelja S, Richards D, Hood J, Coffee K, Nemunaitis J.

Mol Ther. 2005 Jan;11(1):149-59.

4.

mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic.

Fisher PB, Gopalkrishnan RV, Chada S, Ramesh R, Grimm EA, Rosenfeld MR, Curiel DT, Dent P.

Cancer Biol Ther. 2003 Jul-Aug;2(4 Suppl 1):S23-37. Review.

PMID:
14508078
5.

mda-7/IL-24: exploiting cancer's Achilles' heel.

Lebedeva IV, Sauane M, Gopalkrishnan RV, Sarkar D, Su ZZ, Gupta P, Nemunaitis J, Cunningham C, Yacoub A, Dent P, Fisher PB.

Mol Ther. 2005 Jan;11(1):4-18. Review.

6.

Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24.

Emdad L, Lebedeva IV, Su ZZ, Gupta P, Sauane M, Dash R, Grant S, Dent P, Curiel DT, Sarkar D, Fisher PB.

Cancer Biol Ther. 2009 Mar;8(5):391-400. Epub 2009 Mar 8. Review.

PMID:
19276652
7.

mda-7 (IL-24): signaling and functional roles.

Sarkar D, Su ZZ, Lebedeva IV, Sauane M, Gopalkrishnan RV, Dent P, Fisher PB.

Biotechniques. 2002 Oct;Suppl:30-9.

PMID:
12395925
8.

mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review).

Lebedeva IV, Emdad L, Su ZZ, Gupta P, Sauane M, Sarkar D, Staudt MR, Liu SJ, Taher MM, Xiao R, Barral P, Lee SG, Wang D, Vozhilla N, Park ES, Chatman L, Boukerche H, Ramesh R, Inoue S, Chada S, Li R, De Pass AL, Mahasreshti PJ, Dmitriev IP, Curiel DT, Yacoub A, Grant S, Dent P, Senzer N, Nemunaitis JJ, Fisher PB.

Int J Oncol. 2007 Nov;31(5):985-1007. Review.

PMID:
17912425
9.

Melanoma differentiation associated gene-7/interleukin-24 promotes tumor cell-specific apoptosis through both secretory and nonsecretory pathways.

Sauane M, Lebedeva IV, Su ZZ, Choo HT, Randolph A, Valerie K, Dent P, Gopalkrishnan RV, Fisher PB.

Cancer Res. 2004 May 1;64(9):2988-93.

10.

Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy?

Sarkar D, Lebedeva IV, Gupta P, Emdad L, Sauane M, Dent P, Curiel DT, Fisher PB.

Expert Opin Biol Ther. 2007 May;7(5):577-86. Review.

PMID:
17477796
11.

MDA-7/IL-24-based cancer gene therapy: translation from the laboratory to the clinic.

Inoue S, Shanker M, Miyahara R, Gopalan B, Patel S, Oida Y, Branch CD, Munshi A, Meyn RE, Andreeff M, Tanaka F, Mhashilkar AM, Chada S, Ramesh R.

Curr Gene Ther. 2006 Feb;6(1):73-91. Review.

PMID:
16475947
12.

Cytokine and tumor cell apoptosis inducing activity of mda-7/IL-24.

Gopalkrishnan RV, Sauane M, Fisher PB.

Int Immunopharmacol. 2004 May;4(5):635-47. Review.

PMID:
15120649
13.

Is mda-7/IL-24 a "magic bullet" for cancer?

Fisher PB.

Cancer Res. 2005 Nov 15;65(22):10128-38. Review.

14.

MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.

Chada S, Sutton RB, Ekmekcioglu S, Ellerhorst J, Mumm JB, Leitner WW, Yang HY, Sahin AA, Hunt KK, Fuson KL, Po├Čndexter N, Roth JA, Ramesh R, Grimm EA, Mhashilkar AM.

Int Immunopharmacol. 2004 May;4(5):649-67. Review.

PMID:
15120650
15.

MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine.

Sauane M, Gopalkrishnan RV, Sarkar D, Su ZZ, Lebedeva IV, Dent P, Pestka S, Fisher PB.

Cytokine Growth Factor Rev. 2003 Feb;14(1):35-51. Review.

PMID:
12485618
16.

[Effects of adenoviral-mediated melanoma differentiation associated gene-7/IL-24 on growth and apoptosis of breast cancer cells].

Ni QC, Yang L, Zhang CH, Zhou F, Zhu HJ, Huang JF.

Zhonghua Yi Xue Za Zhi. 2008 Nov 18;88(42):3008-11. Chinese.

PMID:
19080082
17.

Adenovirus vector expressing mda-7 selectively kills hepatocellular carcinoma cell line Hep3B.

Xue XB, Chen K, Wang CJ, Zheng JW, Yu Y, Peng ZH, Wu ZD.

Hepatobiliary Pancreat Dis Int. 2008 Oct;7(5):509-14.

18.

[Mechanisms responsible for antitumor activity of melanoma differentiation-associated gene -7/interleukin-24].

Yang M, Qian WB.

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007 Jan;36(1):98-102. Review. Chinese.

PMID:
17290500
19.

INGN-241. Introgen.

Gopalkrishnan R.

Curr Opin Investig Drugs. 2002 Dec;3(12):1773-7. Review.

PMID:
12528316
20.

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma.

Fisher PB, Sarkar D, Lebedeva IV, Emdad L, Gupta P, Sauane M, Su ZZ, Grant S, Dent P, Curiel DT, Senzer N, Nemunaitis J.

Toxicol Appl Pharmacol. 2007 Nov 1;224(3):300-7. Epub 2006 Nov 23. Review.

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