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Items: 1 to 20 of 111

1.

Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function.

Wacker JL, Feller DB, Tang XB, Defino MC, Namkung Y, Lyssand JS, Mhyre AJ, Tan X, Jensen JB, Hague C.

J Biol Chem. 2008 Nov 7;283(45):31068-78. doi: 10.1074/jbc.M805251200. Epub 2008 Sep 4.

2.

Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells.

Malik RU, Ritt M, DeVree BT, Neubig RR, Sunahara RK, Sivaramakrishnan S.

J Biol Chem. 2013 Jun 14;288(24):17167-78. doi: 10.1074/jbc.M113.464065. Epub 2013 Apr 29.

3.

Disease-causing mutation in PKR2 receptor reveals a critical role of positive charges in the second intracellular loop for G-protein coupling and receptor trafficking.

Peng Z, Tang Y, Luo H, Jiang F, Yang J, Sun L, Li JD.

J Biol Chem. 2011 May 13;286(19):16615-22. doi: 10.1074/jbc.M111.223784. Epub 2011 Mar 16.

4.

The GPR54 gene as a regulator of puberty.

Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF Jr, Aparicio SA, Colledge WH.

N Engl J Med. 2003 Oct 23;349(17):1614-27.

5.

Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.

Ivey FD, Taglia FX, Yang F, Lander MM, Kelly DA, Hoffman CS.

Eukaryot Cell. 2010 Apr;9(4):626-33. doi: 10.1128/EC.00010-10. Epub 2010 Feb 5.

6.

A dominant-negative Galpha mutant that traps a stable rhodopsin-Galpha-GTP-betagamma complex.

Ramachandran S, Cerione RA.

J Biol Chem. 2011 Apr 8;286(14):12702-11. doi: 10.1074/jbc.M110.166538. Epub 2011 Feb 1.

7.

Universal allosteric mechanism for Gα activation by GPCRs.

Flock T, Ravarani CNJ, Sun D, Venkatakrishnan AJ, Kayikci M, Tate CG, Veprintsev DB, Babu MM.

Nature. 2015 Aug 13;524(7564):173-179. doi: 10.1038/nature14663. Epub 2015 Jul 6.

8.

Neuroendocrine, gonadal, placental, and obstetric phenotypes in patients with IHH and mutations in the G-protein coupled receptor, GPR54.

Pallais JC, Bo-Abbas Y, Pitteloud N, Crowley WF Jr, Seminara SB.

Mol Cell Endocrinol. 2006 Jul 25;254-255:70-7. Epub 2006 Jun 6.

PMID:
16757106
9.

Drosophila GoLoco-protein Pins is a target of Galpha(o)-mediated G protein-coupled receptor signaling.

Kopein D, Katanaev VL.

Mol Biol Cell. 2009 Sep;20(17):3865-77. doi: 10.1091/mbc.E09-01-0021. Epub 2009 Jul 1.

10.

A novel loss-of-function mutation in GPR54/KISS1R leads to hypogonadotropic hypogonadism in a highly consanguineous family.

Nimri R, Lebenthal Y, Lazar L, Chevrier L, Phillip M, Bar M, Hernandez-Mora E, de Roux N, Gat-Yablonski G.

J Clin Endocrinol Metab. 2011 Mar;96(3):E536-45. doi: 10.1210/jc.2010-1676. Epub 2010 Dec 30.

PMID:
21193544
12.

Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction.

Heydorn A, Ward RJ, Jorgensen R, Rosenkilde MM, Frimurer TM, Milligan G, Kostenis E.

Mol Pharmacol. 2004 Aug;66(2):250-9.

13.

Gbetagamma inhibits Galpha GTPase-activating proteins by inhibition of Galpha-GTP binding during stimulation by receptor.

Tang W, Tu Y, Nayak SK, Woodson J, Jehl M, Ross EM.

J Biol Chem. 2006 Feb 24;281(8):4746-53. Epub 2005 Dec 29.

14.

Fusion proteins as model systems for the analysis of constitutive GPCR activity.

Schneider EH, Seifert R.

Methods Enzymol. 2010;485:459-80. doi: 10.1016/B978-0-12-381296-4.00025-7.

PMID:
21050932
15.

Molecular analysis of the interaction between the intracellular loops of the human serotonin receptor type 6 (5-HT6) and the alpha subunit of GS protein.

Kang H, Lee WK, Choi YH, Vukoti KM, Bang WG, Yu YG.

Biochem Biophys Res Commun. 2005 Apr 8;329(2):684-92.

PMID:
15737640
16.

A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity.

Kostenis E, Martini L, Ellis J, Waldhoer M, Heydorn A, Rosenkilde MM, Norregaard PK, Jorgensen R, Whistler JL, Milligan G.

J Pharmacol Exp Ther. 2005 Apr;313(1):78-87. Epub 2004 Dec 22.

17.
18.

A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis.

Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP.

PLoS Pathog. 2012 Feb;8(2):e1002553. doi: 10.1371/journal.ppat.1002553. Epub 2012 Feb 23.

19.

Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a L102P inactivating mutation of GPR54.

Tenenbaum-Rakover Y, Commenges-Ducos M, Iovane A, Aumas C, Admoni O, de Roux N.

J Clin Endocrinol Metab. 2007 Mar;92(3):1137-44. Epub 2006 Dec 12.

PMID:
17164310
20.

Analysis of G-protein-coupled receptor kinase RGS homology domains.

Day PW, Wedegaertner PB, Benovic JL.

Methods Enzymol. 2004;390:295-310.

PMID:
15488185

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