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Restoration of vitamin C synthesis in transgenic Gulo-/- mice by helper-dependent adenovirus-based expression of gulonolactone oxidase.

Li Y, Shi CX, Mossman KL, Rosenfeld J, Boo YC, Schellhorn HE.

Hum Gene Ther. 2008 Dec;19(12):1349-58. doi: 10.1089/hgt.2008.106.


Functional rescue of vitamin C synthesis deficiency in human cells using adenoviral-based expression of murine l-gulono-gamma-lactone oxidase.

Ha MN, Graham FL, D'Souza CK, Muller WJ, Igdoura SA, Schellhorn HE.

Genomics. 2004 Mar;83(3):482-92.


Ascorbic acid synthesis due to L-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells.

Kim HJ, Lee SI, Lee DH, Smith D, Jo H, Schellhorn HE, Boo YC.

Biochem Biophys Res Commun. 2006 Jul 14;345(4):1657-62. Epub 2006 May 24.


Spontaneous fractures in the mouse mutant sfx are caused by deletion of the gulonolactone oxidase gene, causing vitamin C deficiency.

Mohan S, Kapoor A, Singgih A, Zhang Z, Taylor T, Yu H, Chadwick RB, Chung YS, Donahue LR, Rosen C, Crawford GC, Wergedal J, Baylink DJ.

J Bone Miner Res. 2005 Sep;20(9):1597-610. Epub 2005 Apr 18. Erratum in: J Bone Miner Res. 2006 Apr;21(4):657. Chung, Yoon-Suk [corrected to Chung, Yoon-Sok].


Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid.

Harrison FE, Yu SS, Van Den Bossche KL, Li L, May JM, McDonald MP.

J Neurochem. 2008 Aug;106(3):1198-208. doi: 10.1111/j.1471-4159.2008.05469.x. Epub 2008 May 7.


In vivo consequence of vitamin C insufficiency in liver injury: vitamin C ameliorates T-cell-mediated acute liver injury in gulo(-/-) mice.

Bae S, Cho CH, Kim H, Kim Y, Kim HR, Hwang YI, Yoon JH, Kang JS, Lee WJ.

Antioxid Redox Signal. 2013 Dec 10;19(17):2040-53. doi: 10.1089/ars.2012.4756. Epub 2013 Apr 18.


Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver.

Nejak-Bowen KN, Zeng G, Tan X, Cieply B, Monga SP.

J Biol Chem. 2009 Oct 9;284(41):28115-27. doi: 10.1074/jbc.M109.047258. Epub 2009 Aug 18.


Low ascorbic acid and increased oxidative stress in gulo(-/-) mice during development.

Harrison FE, Meredith ME, Dawes SM, Saskowski JL, May JM.

Brain Res. 2010 Aug 19;1349:143-52. doi: 10.1016/j.brainres.2010.06.037. Epub 2010 Jun 20.


Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin C-deficient mice.

Cha J, Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A, Rath M.

Int J Oncol. 2013 Jan;42(1):55-64. doi: 10.3892/ijo.2012.1712. Epub 2012 Nov 21.


Effect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice.

Chen Y, Curran CP, Nebert DW, Patel KV, Williams MT, Vorhees CV.

Genes Brain Behav. 2012 Apr;11(3):269-77. doi: 10.1111/j.1601-183X.2011.00762.x. Epub 2012 Feb 2. Erratum in: Genes Brain Behav. 2012 Jun;11(4):500.


Combined vitamin C and E deficiency induces motor defects in gulo(-/-)/SVCT2(+/-) mice.

Pierce MR, Diasio DL, Rodrigues LM, Harrison FE, May JM.

Nutr Neurosci. 2013 Jul;16(4):160-73. doi: 10.1179/1476830512Y.0000000042. Epub 2012 Dec 4. Erratum in: Nutr Neurosci. 2013 Sep;16(5):240-2.


Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice.

Aumailley L, Warren A, Garand C, Dubois MJ, Paquet ER, Le Couteur DG, Marette A, Cogger VC, Lebel M.

Aging (Albany NY). 2016 Mar;8(3):458-83.


Isolation and characterization of cDNA sequences of L-gulono-gamma-lactone oxidase, a key enzyme for biosynthesis of ascorbic acid, from extant primitive fish groups.

Cho YS, Douglas SE, Gallant JW, Kim KY, Kim DS, Nam YK.

Comp Biochem Physiol B Biochem Mol Biol. 2007 Jun;147(2):178-90. Epub 2007 Jan 24.


Intragenic deletion in the gene encoding L-gulonolactone oxidase causes vitamin C deficiency in pigs.

Hasan L, Vögeli P, Stoll P, Kramer SS, Stranzinger G, Neuenschwander S.

Mamm Genome. 2004 Apr;15(4):323-33.


Vitamin C supplementation does not protect L-gulono-gamma-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancy.

Lee CW, Wang XD, Chien KL, Ge Z, Rickman BH, Rogers AB, Varro A, Whary MT, Wang TC, Fox JG.

Int J Cancer. 2008 Mar 1;122(5):1068-76.


Helicobacter pylori infection combined with DENA revealed altered expression of p53 and 14-3-3 isoforms in Gulo-/- mice.

Nagappan A, Park HS, Park KI, Hong GE, Yumnam S, Lee HJ, Kim MK, Kim EH, Lee WS, Lee WJ, Cho MJ, Lee WK, Won CK, Cho JH, Kim GS.

Chem Biol Interact. 2013 Nov 25;206(2):143-52. doi: 10.1016/j.cbi.2013.09.002. Epub 2013 Sep 11.


Attenuation of sepsis-induced organ injury in mice by vitamin C.

Fisher BJ, Kraskauskas D, Martin EJ, Farkas D, Puri P, Massey HD, Idowu MO, Brophy DF, Voelkel NF, Fowler AA 3rd, Natarajan R.

JPEN J Parenter Enteral Nutr. 2014 Sep;38(7):825-39. doi: 10.1177/0148607113497760. Epub 2013 Aug 5.


L-gulono-γ-lactone oxidase expression and vitamin C synthesis in the brain and kidney of the African lungfish, Protopterus annectens.

Ching B, Ong JL, Chng YR, Chen XL, Wong WP, Chew SF, Ip YK.

FASEB J. 2014 Aug;28(8):3506-17. doi: 10.1096/fj.14-249508. Epub 2014 Apr 25.


Progressive pseudogenization: vitamin C synthesis and its loss in bats.

Cui J, Pan YH, Zhang Y, Jones G, Zhang S.

Mol Biol Evol. 2011 Feb;28(2):1025-31. doi: 10.1093/molbev/msq286. Epub 2010 Oct 29.


Effects of ascorbic acid on carcinogenicity and acute toxicity of nickel subsulfide, and on tumor transplants growth in gulonolactone oxidase knock-out mice and wild-type C57BL mice.

Kasprzak KS, Diwan BA, Kaczmarek MZ, Logsdon DL, Fivash MJ, Salnikow K.

Toxicol Appl Pharmacol. 2011 Nov 15;257(1):32-7. doi: 10.1016/j.taap.2011.08.015. Epub 2011 Aug 22.

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