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PTEN acetylation modulates its interaction with PDZ domain.

Ikenoue T, Inoki K, Zhao B, Guan KL.

Cancer Res. 2008 Sep 1;68(17):6908-12. doi: 10.1158/0008-5472.CAN-08-1107.


A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains.

Sotelo NS, Valiente M, Gil A, Pulido R.

J Cell Biochem. 2012 Aug;113(8):2661-70. doi: 10.1002/jcb.24141.


Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases.

Valiente M, Andrés-Pons A, Gomar B, Torres J, Gil A, Tapparel C, Antonarakis SE, Pulido R.

J Biol Chem. 2005 Aug 12;280(32):28936-43. Epub 2005 Jun 10.


PTEN-PDZ domain interactions: binding of PTEN to PDZ domains of PTPN13.

Sotelo NS, Schepens JT, Valiente M, Hendriks WJ, Pulido R.

Methods. 2015 May;77-78:147-56. doi: 10.1016/j.ymeth.2014.10.017. Epub 2014 Oct 22.


Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding.

Adey NB, Huang L, Ormonde PA, Baumgard ML, Pero R, Byreddy DV, Tavtigian SV, Bartel PL.

Cancer Res. 2000 Jan 1;60(1):35-7.


Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.

Wu X, Hepner K, Castelino-Prabhu S, Do D, Kaye MB, Yuan XJ, Wood J, Ross C, Sawyers CL, Whang YE.

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4233-8.


PCAF modulates PTEN activity.

Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB.

J Biol Chem. 2006 Sep 8;281(36):26562-8. Epub 2006 Jul 7.


APE1/Ref-1 regulates PTEN expression mediated by Egr-1.

Fantini D, Vascotto C, Deganuto M, Bivi N, Gustincich S, Marcon G, Quadrifoglio F, Damante G, Bhakat KK, Mitra S, Tell G.

Free Radic Res. 2008 Jan;42(1):20-9. doi: 10.1080/10715760701765616.


The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region.

Georgescu MM, Kirsch KH, Akagi T, Shishido T, Hanafusa H.

Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10182-7.


Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN.

Terrien E, Chaffotte A, Lafage M, Khan Z, Préhaud C, Cordier F, Simenel C, Delepierre M, Buc H, Lafon M, Wolff N.

Sci Signal. 2012 Aug 14;5(237):ra58. doi: 10.1126/scisignal.2002941.


A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity.

Gil A, Rodríguez-Escudero I, Stumpf M, Molina M, Cid VJ, Pulido R.

PLoS One. 2015 Apr 15;10(4):e0119287. doi: 10.1371/journal.pone.0119287. eCollection 2015.


Mechanistic insights into maintenance of high p53 acetylation by PTEN.

Li AG, Piluso LG, Cai X, Wei G, Sellers WR, Liu X.

Mol Cell. 2006 Aug;23(4):575-87.


An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity.

Stankovic-Valentin N, Deltour S, Seeler J, Pinte S, Vergoten G, Guérardel C, Dejean A, Leprince D.

Mol Cell Biol. 2007 Apr;27(7):2661-75. Epub 2007 Feb 5.


Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells.

Kikuno N, Shiina H, Urakami S, Kawamoto K, Hirata H, Tanaka Y, Majid S, Igawa M, Dahiya R.

Int J Cancer. 2008 Aug 1;123(3):552-60. doi: 10.1002/ijc.23590. Erratum in: Int J Cancer. 2017 Oct 1;141(7):1492.


PDZ domains of Par-3 as potential phosphoinositide signaling integrators.

Wu H, Feng W, Chen J, Chan LN, Huang S, Zhang M.

Mol Cell. 2007 Dec 14;28(5):886-98.


Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs.

Gil A, Andrés-Pons A, Fernández E, Valiente M, Torres J, Cervera J, Pulido R.

Mol Biol Cell. 2006 Sep;17(9):4002-13. Epub 2006 Jun 28.


Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression.

Pan L, Lu J, Wang X, Han L, Zhang Y, Han S, Huang B.

Cancer. 2007 Apr 15;109(8):1676-88.


Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation.

Wang X, Shi Y, Wang J, Huang G, Jiang X.

Biochem J. 2008 Sep 1;414(2):221-9. doi: 10.1042/BJ20080674.


Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.

Leslie NR, Bennett D, Gray A, Pass I, Hoang-Xuan K, Downes CP.

Biochem J. 2001 Jul 15;357(Pt 2):427-35.


Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN.

Cayado-Gutiérrez N, Moncalero VL, Rosales EM, Berón W, Salvatierra EE, Alvarez-Olmedo D, Radrizzani M, Ciocca DR.

Cell Stress Chaperones. 2013 Mar;18(2):243-9. doi: 10.1007/s12192-012-0367-x. Epub 2012 Aug 21.

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