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Items: 1 to 20 of 105


Structure of the guide-strand-containing argonaute silencing complex.

Wang Y, Sheng G, Juranek S, Tuschl T, Patel DJ.

Nature. 2008 Nov 13;456(7219):209-13. doi: 10.1038/nature07315. Epub 2008 Aug 27.


Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex.

Wang Y, Juranek S, Li H, Sheng G, Tuschl T, Patel DJ.

Nature. 2008 Dec 18;456(7224):921-6. doi: 10.1038/nature07666.


Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.

Wang Y, Juranek S, Li H, Sheng G, Wardle GS, Tuschl T, Patel DJ.

Nature. 2009 Oct 8;461(7265):754-61. doi: 10.1038/nature08434.


Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.

Sheng G, Gogakos T, Wang J, Zhao H, Serganov A, Juranek S, Tuschl T, Patel DJ, Wang Y.

Nucleic Acids Res. 2017 Sep 6;45(15):9149-9163. doi: 10.1093/nar/gkx547.


Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage.

Yuan YR, Pei Y, Ma JB, Kuryavyi V, Zhadina M, Meister G, Chen HY, Dauter Z, Tuschl T, Patel DJ.

Mol Cell. 2005 Aug 5;19(3):405-19.


Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.

Ma JB, Yuan YR, Meister G, Pei Y, Tuschl T, Patel DJ.

Nature. 2005 Mar 31;434(7033):666-70.


Structure of Aquifex aeolicus argonaute highlights conformational flexibility of the PAZ domain as a potential regulator of RNA-induced silencing complex function.

Rashid UJ, Paterok D, Koglin A, Gohlke H, Piehler J, Chen JC.

J Biol Chem. 2007 May 4;282(18):13824-32. Epub 2006 Nov 27.


Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.

Sheng G, Zhao H, Wang J, Rao Y, Tian W, Swarts DC, van der Oost J, Patel DJ, Wang Y.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):652-7. doi: 10.1073/pnas.1321032111. Epub 2013 Dec 27.


Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex.

Parker JS, Roe SM, Barford D.

Nature. 2005 Mar 31;434(7033):663-6.


D-Isonucleotide (isoNA) incorporation around cleavage site of passenger strand promotes the vibration of Ago2-PAZ domain and enhances in vitro potency of siRNA.

Huang Y, Tian M, Zhang Y, Sheng G, Chen Z, Ma Y, Chen Y, Peng Y, Zhao YL, Wang Y, Zhang L, Yang Z.

Org Biomol Chem. 2015 Nov 28;13(44):10825-33. doi: 10.1039/c5ob01119a. Epub 2015 Aug 27.


Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain.

Ma JB, Ye K, Patel DJ.

Nature. 2004 May 20;429(6989):318-322. doi: 10.1038/nature02519.


Dynamic anchoring of the 3'-end of the guide strand controls the target dissociation of Argonaute-guide complex.

Jung SR, Kim E, Hwang W, Shin S, Song JJ, Hohng S.

J Am Chem Soc. 2013 Nov 13;135(45):16865-71. doi: 10.1021/ja403138d. Epub 2013 Oct 31.


Crystal structure of Argonaute and its implications for RISC slicer activity.

Song JJ, Smith SK, Hannon GJ, Joshua-Tor L.

Science. 2004 Sep 3;305(5689):1434-7. Epub 2004 Jul 29.


Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity.

Parker JS, Roe SM, Barford D.

EMBO J. 2004 Dec 8;23(24):4727-37. Epub 2004 Nov 25.


Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute.

Miyoshi T, Ito K, Murakami R, Uchiumi T.

Nat Commun. 2016 Jun 21;7:11846. doi: 10.1038/ncomms11846.


Mechanism of microRNA-target interaction: molecular dynamics simulations and thermodynamics analysis.

Wang Y, Li Y, Ma Z, Yang W, Ai C.

PLoS Comput Biol. 2010 Jul 29;6(7):e1000866. doi: 10.1371/journal.pcbi.1000866.


Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein.

Boland A, Tritschler F, Heimstädt S, Izaurralde E, Weichenrieder O.

EMBO Rep. 2010 Jul;11(7):522-7. doi: 10.1038/embor.2010.81. Epub 2010 Jun 11.


Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements.

Makarova KS, Wolf YI, van der Oost J, Koonin EV.

Biol Direct. 2009 Aug 25;4:29. doi: 10.1186/1745-6150-4-29.


The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.

Song JJ, Liu J, Tolia NH, Schneiderman J, Smith SK, Martienssen RA, Hannon GJ, Joshua-Tor L.

Nat Struct Biol. 2003 Dec;10(12):1026-32. Epub 2003 Nov 16.


Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus.

Löw C, Neumann P, Tidow H, Weininger U, Haupt C, Friedrich-Epler B, Scholz C, Stubbs MT, Balbach J.

J Mol Biol. 2010 May 7;398(3):375-90. doi: 10.1016/j.jmb.2010.03.014. Epub 2010 Mar 15.


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