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Items: 1 to 20 of 164

1.

Comparison of ABC transporter modulation by atazanavir in lymphocytes and human brain endothelial cells: ABC transporters are involved in the atazanavir-limited passage across an in vitro human model of the blood-brain barrier.

Bousquet L, Roucairol C, Hembury A, Nevers MC, Creminon C, Farinotti R, Mabondzo A.

AIDS Res Hum Retroviruses. 2008 Sep;24(9):1147-54. doi: 10.1089/aid.2007.0022.

PMID:
18729774
2.

Role of P-glycoprotein in the distribution of the HIV protease inhibitor atazanavir in the brain and male genital tract.

Robillard KR, Chan GN, Zhang G, la Porte C, Cameron W, Bendayan R.

Antimicrob Agents Chemother. 2014;58(3):1713-22. doi: 10.1128/AAC.02031-13. Epub 2013 Dec 30.

3.

Expression of ATP-binding cassette membrane transporters in rodent and human sertoli cells: relevance to the permeability of antiretroviral therapy at the blood-testis barrier.

Robillard KR, Hoque T, Bendayan R.

J Pharmacol Exp Ther. 2012 Jan;340(1):96-108. doi: 10.1124/jpet.111.186916. Epub 2011 Oct 11.

4.

Up-regulation of P-glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line.

Zastre JA, Chan GN, Ronaldson PT, Ramaswamy M, Couraud PO, Romero IA, Weksler B, Bendayan M, Bendayan R.

J Neurosci Res. 2009 Mar;87(4):1023-36. doi: 10.1002/jnr.21898.

PMID:
18855943
5.

Influence of atazanavir 200 mg on the intracellular and plasma pharmacokinetics of saquinavir and ritonavir 1600/100 mg administered once daily in HIV-infected patients.

Ford J, Boffito M, Maitland D, Hill A, Back D, Khoo S, Nelson M, Moyle G, Gazzard B, Pozniak A.

J Antimicrob Chemother. 2006 Nov;58(5):1009-16. Epub 2006 Sep 19.

PMID:
16984898
6.

Interindividual variability in the effect of atazanavir and saquinavir on the expression of lymphocyte P-glycoprotein.

Chinn LW, Gow JM, Tse MM, Becker SL, Kroetz DL.

J Antimicrob Chemother. 2007 Jul;60(1):61-7. Epub 2007 May 17.

PMID:
17510066
7.

Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers.

Miller DW, Hinton M, Chen F.

Neurourol Urodyn. 2011 Nov;30(8):1633-8. doi: 10.1002/nau.21110. Epub 2011 Aug 8.

PMID:
21826715
8.

Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines.

Bierman WF, Scheffer GL, Schoonderwoerd A, Jansen G, van Agtmael MA, Danner SA, Scheper RJ.

J Antimicrob Chemother. 2010 Aug;65(8):1672-80. doi: 10.1093/jac/dkq209. Epub 2010 Jun 15.

PMID:
20551216
9.

An electrically tight in vitro blood-brain barrier model displays net brain-to-blood efflux of substrates for the ABC transporters, P-gp, Bcrp and Mrp-1.

Helms HC, Hersom M, Kuhlmann LB, Badolo L, Nielsen CU, Brodin B.

AAPS J. 2014 Sep;16(5):1046-55. doi: 10.1208/s12248-014-9628-1. Epub 2014 Jun 17.

10.

P-glycoprotein, multidrug resistance-associated proteins and human organic anion transporting polypeptide influence the intracellular accumulation of atazanavir.

Janneh O, Anwar T, Jungbauer C, Kopp S, Khoo SH, Back DJ, Chiba P.

Antivir Ther. 2009;14(7):965-74. doi: 10.3851/IMP1399.

PMID:
19918100
11.
12.

(R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood-brain barrier, and not by MRP1 and BCRP.

Römermann K, Wanek T, Bankstahl M, Bankstahl JP, Fedrowitz M, Müller M, Löscher W, Kuntner C, Langer O.

Nucl Med Biol. 2013 Oct;40(7):873-8. doi: 10.1016/j.nucmedbio.2013.05.012. Epub 2013 Jul 8.

13.

ATP-binding cassette transporters in primary central nervous system lymphoma: decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells.

Sakata S, Fujiwara M, Ohtsuka K, Kamma H, Nagane M, Sakamoto A, Fujioka Y.

Oncol Rep. 2011 Feb;25(2):333-9. doi: 10.3892/or.2010.1102. Epub 2010 Dec 13.

PMID:
21165575
14.

ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) expression in the developing human CNS.

Daood M, Tsai C, Ahdab-Barmada M, Watchko JF.

Neuropediatrics. 2008 Aug;39(4):211-8. doi: 10.1055/s-0028-1103272. Epub 2009 Jan 22.

15.

Expression of ATP-binding cassette transporters at the inner blood-retinal barrier in a neonatal mouse model of oxygen-induced retinopathy.

Tagami M, Kusuhara S, Honda S, Tsukahara Y, Negi A.

Brain Res. 2009 Aug 4;1283:186-93. doi: 10.1016/j.brainres.2009.05.095. Epub 2009 Jun 6.

PMID:
19505448
16.

P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?

Jones K, Bray PG, Khoo SH, Davey RA, Meaden ER, Ward SA, Back DJ.

AIDS. 2001 Jul 27;15(11):1353-8.

PMID:
11504956
17.

P-glycoprotein mediated efflux limits the transport of the novel anti-Parkinson's disease candidate drug FLZ across the physiological and PD pathological in vitro BBB models.

Liu Q, Hou J, Chen X, Liu G, Zhang D, Sun H, Zhang J.

PLoS One. 2014 Jul 18;9(7):e102442. doi: 10.1371/journal.pone.0102442. eCollection 2014.

18.

Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.

Cisternino S, Mercier C, Bourasset F, Roux F, Scherrmann JM.

Cancer Res. 2004 May 1;64(9):3296-301.

19.

(18)F-FCWAY, a serotonin 1A receptor radioligand, is a substrate for efflux transport at the human blood-brain barrier.

Liow JS, Zoghbi SS, Hu S, Hall MD, Hines CS, Shetty HU, Araneta MD, Page EM, Pike VW, Kreisl WC, Herscovitch P, Gottesman MM, Theodore WH, Innis RB.

Neuroimage. 2016 Sep;138:134-140. doi: 10.1016/j.neuroimage.2016.05.045. Epub 2016 May 19.

20.

Characterisation of the brain multidrug resistance protein (BMDP/ABCG2/BCRP) expressed at the blood-brain barrier.

Eisenblätter T, Hüwel S, Galla HJ.

Brain Res. 2003 May 9;971(2):221-31.

PMID:
12706238

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