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Items: 1 to 20 of 167

1.

Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells.

Wang L, Pal S, Sif S.

Mol Cell Biol. 2008 Oct;28(20):6262-77. doi: 10.1128/MCB.00923-08. Epub 2008 Aug 11.

2.

Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes.

Tae S, Karkhanis V, Velasco K, Yaneva M, Erdjument-Bromage H, Tempst P, Sif S.

Nucleic Acids Res. 2011 Jul;39(13):5424-38. doi: 10.1093/nar/gkr170. Epub 2011 Mar 29.

3.

Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.

Chung J, Karkhanis V, Tae S, Yan F, Smith P, Ayers LW, Agostinelli C, Pileri S, Denis GV, Baiocchi RA, Sif S.

J Biol Chem. 2013 Dec 6;288(49):35534-47. doi: 10.1074/jbc.M113.510669. Epub 2013 Nov 4.

4.

Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma.

Pal S, Baiocchi RA, Byrd JC, Grever MR, Jacob ST, Sif S.

EMBO J. 2007 Aug 8;26(15):3558-69. Epub 2007 Jul 12.

5.

Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.

Pal S, Vishwanath SN, Erdjument-Bromage H, Tempst P, Sif S.

Mol Cell Biol. 2004 Nov;24(21):9630-45.

6.

The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation.

Tarighat SS, Santhanam R, Frankhouser D, Radomska HS, Lai H, Anghelina M, Wang H, Huang X, Alinari L, Walker A, Caligiuri MA, Croce CM, Li L, Garzon R, Li C, Baiocchi RA, Marcucci G.

Leukemia. 2016 Apr;30(4):789-99. doi: 10.1038/leu.2015.308. Epub 2015 Nov 5.

PMID:
26536822
7.

Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase.

Aggarwal P, Vaites LP, Kim JK, Mellert H, Gurung B, Nakagawa H, Herlyn M, Hua X, Rustgi AK, McMahon SB, Diehl JA.

Cancer Cell. 2010 Oct 19;18(4):329-40. doi: 10.1016/j.ccr.2010.08.012.

8.

Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth.

Deng X, Shao G, Zhang HT, Li C, Zhang D, Cheng L, Elzey BD, Pili R, Ratliff TL, Huang J, Hu CD.

Oncogene. 2017 Mar 2;36(9):1223-1231. doi: 10.1038/onc.2016.287. Epub 2016 Aug 22.

10.

The protein arginine methyltransferase Prmt5 is required for myogenesis because it facilitates ATP-dependent chromatin remodeling.

Dacwag CS, Ohkawa Y, Pal S, Sif S, Imbalzano AN.

Mol Cell Biol. 2007 Jan;27(1):384-94. Epub 2006 Oct 16.

11.

Methylation of histone H3 and H4 by PRMT5 regulates ribosomal RNA gene transcription.

Majumder S, Alinari L, Roy S, Miller T, Datta J, Sif S, Baiocchi R, Jacob ST.

J Cell Biochem. 2010 Feb 15;109(3):553-63. doi: 10.1002/jcb.22432.

12.

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.

Alinari L, Mahasenan KV, Yan F, Karkhanis V, Chung JH, Smith EM, Quinion C, Smith PL, Kim L, Patton JT, Lapalombella R, Yu B, Wu Y, Roy S, De Leo A, Pileri S, Agostinelli C, Ayers L, Bradner JE, Chen-Kiang S, Elemento O, Motiwala T, Majumder S, Byrd JC, Jacob S, Sif S, Li C, Baiocchi RA.

Blood. 2015 Apr 16;125(16):2530-43. doi: 10.1182/blood-2014-12-619783. Epub 2015 Mar 5.

13.

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing.

Zhao Q, Rank G, Tan YT, Li H, Moritz RL, Simpson RJ, Cerruti L, Curtis DJ, Patel DJ, Allis CD, Cunningham JM, Jane SM.

Nat Struct Mol Biol. 2009 Mar;16(3):304-311. doi: 10.1038/nsmb.1568. Epub 2009 Feb 22.

14.

A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.

Chen H, Lorton B, Gupta V, Shechter D.

Oncogene. 2017 Jan 19;36(3):373-386. doi: 10.1038/onc.2016.205. Epub 2016 Jun 6.

15.

Hepatitis C virus core protein modulates pRb2/p130 expression in human hepatocellular carcinoma cell lines through promoter methylation.

Mileo AM, Mattarocci S, Matarrese P, Anticoli S, Abbruzzese C, Catone S, Sacco R, Paggi MG, Ruggieri A.

J Exp Clin Cancer Res. 2015 Nov 14;34:140. doi: 10.1186/s13046-015-0255-1.

16.

The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase.

Terashima M, Ishimura A, Yoshida M, Suzuki Y, Sugano S, Suzuki T.

Biochem Biophys Res Commun. 2010 Aug 20;399(2):238-44. doi: 10.1016/j.bbrc.2010.07.061. Epub 2010 Jul 30.

PMID:
20650264
17.

mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.

Pal S, Yun R, Datta A, Lacomis L, Erdjument-Bromage H, Kumar J, Tempst P, Sif S.

Mol Cell Biol. 2003 Nov;23(21):7475-87.

18.

PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers.

Li Y, Chitnis N, Nakagawa H, Kita Y, Natsugoe S, Yang Y, Li Z, Wasik M, Klein-Szanto AJ, Rustgi AK, Diehl JA.

Cancer Discov. 2015 Mar;5(3):288-303. doi: 10.1158/2159-8290.CD-14-0625. Epub 2015 Jan 12.

19.

The Kruppel-like zinc finger protein ZNF224 recruits the arginine methyltransferase PRMT5 on the transcriptional repressor complex of the aldolase A gene.

Cesaro E, De Cegli R, Medugno L, Florio F, Grosso M, Lupo A, Izzo P, Costanzo P.

J Biol Chem. 2009 Nov 20;284(47):32321-30. doi: 10.1074/jbc.M109.043349. Epub 2009 Sep 9.

20.

AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin.

Teng Y, Girvan AC, Casson LK, Pierce WM Jr, Qian M, Thomas SD, Bates PJ.

Cancer Res. 2007 Nov 1;67(21):10491-500.

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