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Items: 1 to 20 of 103

1.

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.

Schüller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG, Huillard E, Sun T, Ligon AH, Qian Y, Ma Q, Alvarez-Buylla A, McMahon AP, Rowitch DH, Ligon KL.

Cancer Cell. 2008 Aug 12;14(2):123-34. doi: 10.1016/j.ccr.2008.07.005.

2.

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem.

Grammel D, Warmuth-Metz M, von Bueren AO, Kool M, Pietsch T, Kretzschmar HA, Rowitch DH, Rutkowski S, Pfister SM, Schüller U.

Acta Neuropathol. 2012 Apr;123(4):601-14. doi: 10.1007/s00401-012-0961-0. Epub 2012 Feb 21.

PMID:
22349907
3.

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.

Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ, Wechsler-Reya RJ.

Cancer Cell. 2008 Aug 12;14(2):135-45. doi: 10.1016/j.ccr.2008.07.003.

4.

Even cancers want commitment: lineage identity and medulloblastoma formation.

Eberhart CG.

Cancer Cell. 2008 Aug 12;14(2):105-7. doi: 10.1016/j.ccr.2008.07.011.

5.
6.

BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma.

Shackleford GM, Shi XH, Swanson KS, Mahdi MY, Gonzalez-Gomez I, Asgharzadeh S, D'Apuzzo M, Erdreich-Epstein A, Moats RA.

PLoS One. 2016 Jun 16;11(6):e0156907. doi: 10.1371/journal.pone.0156907. eCollection 2016.

7.

The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.

Northcott PA, Fernandez-L A, Hagan JP, Ellison DW, Grajkowska W, Gillespie Y, Grundy R, Van Meter T, Rutka JT, Croce CM, Kenney AM, Taylor MD.

Cancer Res. 2009 Apr 15;69(8):3249-55. doi: 10.1158/0008-5472.CAN-08-4710. Epub 2009 Apr 7.

8.

Hepatocyte growth factor and sonic Hedgehog expression in cerebellar neural progenitor cells costimulate medulloblastoma initiation and growth.

Binning MJ, Niazi T, Pedone CA, Lal B, Eberhart CG, Kim KJ, Laterra J, Fults DW.

Cancer Res. 2008 Oct 1;68(19):7838-45. doi: 10.1158/0008-5472.CAN-08-1899.

9.

Dual and opposing roles of primary cilia in medulloblastoma development.

Han YG, Kim HJ, Dlugosz AA, Ellison DW, Gilbertson RJ, Alvarez-Buylla A.

Nat Med. 2009 Sep;15(9):1062-5. doi: 10.1038/nm.2020. Epub 2009 Aug 23.

10.

YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells.

Dey A, Robitaille M, Remke M, Maier C, Malhotra A, Gregorieff A, Wrana JL, Taylor MD, Angers S, Kenney AM.

Oncogene. 2016 Aug 11;35(32):4256-68. doi: 10.1038/onc.2015.491. Epub 2016 Jan 4.

11.

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation.

Fernandez-L A, Northcott PA, Dalton J, Fraga C, Ellison D, Angers S, Taylor MD, Kenney AM.

Genes Dev. 2009 Dec 1;23(23):2729-41. doi: 10.1101/gad.1824509.

12.

Astroglial cells in the external granular layer are precursors of cerebellar granule neurons in neonates.

Silbereis J, Heintz T, Taylor MM, Ganat Y, Ment LR, Bordey A, Vaccarino F.

Mol Cell Neurosci. 2010 Aug;44(4):362-73. doi: 10.1016/j.mcn.2010.05.001. Epub 2010 May 12.

13.

Isolation, enrichment, and maintenance of medulloblastoma stem cells.

Huang X, Ketova T, Litingtung Y, Chiang C.

J Vis Exp. 2010 Sep 1;(43). pii: 2086. doi: 10.3791/2086.

14.

Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool.

Spassky N, Han YG, Aguilar A, Strehl L, Besse L, Laclef C, Ros MR, Garcia-Verdugo JM, Alvarez-Buylla A.

Dev Biol. 2008 May 1;317(1):246-59. doi: 10.1016/j.ydbio.2008.02.026. Epub 2008 Mar 4.

15.

c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice.

Rao G, Pedone CA, Coffin CM, Holland EC, Fults DW.

Neoplasia. 2003 May-Jun;5(3):198-204. doi: 10.1016/S1476-5586(03)80052-0.

16.

Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization.

Bhatia B, Northcott PA, Hambardzumyan D, Govindarajan B, Brat DJ, Arbiser JL, Holland EC, Taylor MD, Kenney AM.

Cancer Res. 2009 Sep 15;69(18):7224-34. doi: 10.1158/0008-5472.CAN-09-1299. Epub 2009 Sep 8.

17.
18.

Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma.

Malhotra A, Dey A, Prasad N, Kenney AM.

Mol Cancer Res. 2016 Jan;14(1):114-24. doi: 10.1158/1541-7786.MCR-15-0278. Epub 2015 Oct 7.

19.

Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma.

Flora A, Klisch TJ, Schuster G, Zoghbi HY.

Science. 2009 Dec 4;326(5958):1424-7. doi: 10.1126/science.1181453. Erratum in: Science. 2010 Mar 19;327(5972):1454.

20.

Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.

Parathath SR, Mainwaring LA, Fernandez-L A, Campbell DO, Kenney AM.

Development. 2008 Oct;135(19):3291-300. doi: 10.1242/dev.022871. Epub 2008 Aug 28.

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