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ENaC and its regulatory proteins as drug targets for blood pressure control.

Rotin D, Schild L.

Curr Drug Targets. 2008 Aug;9(8):709-16. Review.


Role of the UPS in Liddle syndrome.

Rotin D.

BMC Biochem. 2008 Oct 21;9 Suppl 1:S5. doi: 10.1186/1471-2091-9-S1-S5. Review.


Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination.

Staub O, Abriel H, Plant P, Ishikawa T, Kanelis V, Saleki R, Horisberger JD, Schild L, Rotin D.

Kidney Int. 2000 Mar;57(3):809-15. Review.


The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool.

Lu C, Pribanic S, Debonneville A, Jiang C, Rotin D.

Traffic. 2007 Sep;8(9):1246-64. Epub 2007 Jul 1.


Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways.

Zhou R, Kabra R, Olson DR, Piper RC, Snyder PM.

J Biol Chem. 2010 Oct 1;285(40):30523-30. doi: 10.1074/jbc.M110.150755. Epub 2010 Jul 30.


Affinity and specificity of interactions between Nedd4 isoforms and the epithelial Na+ channel.

Henry PC, Kanelis V, O'Brien MC, Kim B, Gautschi I, Forman-Kay J, Schild L, Rotin D.

J Biol Chem. 2003 May 30;278(22):20019-28. Epub 2003 Mar 22.


Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC.

Zhou R, Patel SV, Snyder PM.

J Biol Chem. 2007 Jul 13;282(28):20207-12. Epub 2007 May 14.


Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.

Knight KK, Olson DR, Zhou R, Snyder PM.

Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2805-8. Epub 2006 Feb 13.


Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation.

Wiemuth D, Lott JS, Ly K, Ke Y, Teesdale-Spittle P, Snyder PM, McDonald FJ.

PLoS One. 2010 Aug 13;5(8):e12163. doi: 10.1371/journal.pone.0012163.


Solution structure of a Nedd4 WW domain-ENaC peptide complex.

Kanelis V, Rotin D, Forman-Kay JD.

Nat Struct Biol. 2001 May;8(5):407-12.


Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway.

Gille T, Randrianarison-Pellan N, Goolaerts A, Dard N, Uzunhan Y, Ferrary E, Hummler E, Clerici C, Plan├Ęs C.

Am J Respir Cell Mol Biol. 2014 Mar;50(3):526-37. doi: 10.1165/rcmb.2012-0518OC.


Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.

Shi PP, Cao XR, Sweezer EM, Kinney TS, Williams NR, Husted RF, Nair R, Weiss RM, Williamson RA, Sigmund CD, Snyder PM, Staub O, Stokes JB, Yang B.

Am J Physiol Renal Physiol. 2008 Aug;295(2):F462-70. doi: 10.1152/ajprenal.90300.2008. Epub 2008 Jun 4.


Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

Abriel H, Loffing J, Rebhun JF, Pratt JH, Schild L, Horisberger JD, Rotin D, Staub O.

J Clin Invest. 1999 Mar;103(5):667-73.


Salt-induced hypertension in a mouse model of Liddle syndrome is mediated by epithelial sodium channels in the brain.

Van Huysse JW, Amin MS, Yang B, Leenen FH.

Hypertension. 2012 Sep;60(3):691-6. doi: 10.1161/HYPERTENSIONAHA.112.193045. Epub 2012 Jul 16.


WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

Staub O, Dho S, Henry P, Correa J, Ishikawa T, McGlade J, Rotin D.

EMBO J. 1996 May 15;15(10):2371-80.


Impact of Nedd4 proteins and serum and glucocorticoid-induced kinases on epithelial Na+ transport in the distal nephron.

Staub O, Verrey F.

J Am Soc Nephrol. 2005 Nov;16(11):3167-74. Epub 2005 Sep 28. Review.


Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.

Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S.

J Biol Chem. 2002 Aug 16;277(33):29406-16. Epub 2002 Jun 5.


Cystic fibrosis transmembrane conductance regulator inhibits epithelial Na+ channels carrying Liddle's syndrome mutations.

Hopf A, Schreiber R, Mall M, Greger R, Kunzelmann K.

J Biol Chem. 1999 May 14;274(20):13894-9.


The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels.

Fotia AB, Dinudom A, Shearwin KE, Koch JP, Korbmacher C, Cook DI, Kumar S.

FASEB J. 2003 Jan;17(1):70-2. Epub 2002 Nov 1.


Nedd4-2 induces endocytosis and degradation of proteolytically cleaved epithelial Na+ channels.

Kabra R, Knight KK, Zhou R, Snyder PM.

J Biol Chem. 2008 Mar 7;283(10):6033-9. doi: 10.1074/jbc.M708555200. Epub 2008 Jan 3.

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