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Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7.

Oshima T, Miwa H, Joh T.

Am J Physiol Cell Physiol. 2008 Sep;295(3):C800-6. doi: 10.1152/ajpcell.00157.2008. Epub 2008 Jul 30.


Attenuated expression of the tight junction proteins is involved in clopidogrel-induced gastric injury through p38 MAPK activation.

Wu HL, Gao X, Jiang ZD, Duan ZT, Wang SK, He BS, Zhang ZY, Xie HG.

Toxicology. 2013 Feb 8;304:41-8. doi: 10.1016/j.tox.2012.11.020. Epub 2012 Dec 7.


Indomethacin induces increase in gastric epithelial tight junction permeability via redistribution of occludin and activation of p38 MAPK in MKN-28 Cells.

Thakre-Nighot M, Blikslager AT.

Tissue Barriers. 2016 May 18;4(3):e1187325. doi: 10.1080/21688370.2016.1187325. eCollection 2016 Jul-Sep.


Oxidative stress induces gastric epithelial permeability through claudin-3.

Hashimoto K, Oshima T, Tomita T, Kim Y, Matsumoto T, Joh T, Miwa H.

Biochem Biophys Res Commun. 2008 Nov 7;376(1):154-7. doi: 10.1016/j.bbrc.2008.08.140. Epub 2008 Sep 5.


ERK is involved in EGF-mediated protection of tight junctions, but not adherens junctions, in acetaldehyde-treated Caco-2 cell monolayers.

Samak G, Aggarwal S, Rao RK.

Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G50-9. doi: 10.1152/ajpgi.00494.2010. Epub 2011 Apr 7.


Sirolimus and cyclosporine A alter barrier function in renal proximal tubular cells through stimulation of ERK1/2 signaling and claudin-1 expression.

Martin-Martin N, Ryan G, McMorrow T, Ryan MP.

Am J Physiol Renal Physiol. 2010 Mar;298(3):F672-82. doi: 10.1152/ajprenal.00199.2009. Epub 2009 Dec 2.


Alcohol increases the permeability of airway epithelial tight junctions in Beas-2B and NHBE cells.

Simet SM, Wyatt TA, DeVasure J, Yanov D, Allen-Gipson D, Sisson JH.

Alcohol Clin Exp Res. 2012 Mar;36(3):432-42. doi: 10.1111/j.1530-0277.2011.01640.x. Epub 2011 Sep 26.


Interleukin-18 facilitates neutrophil transmigration via myosin light chain kinase-dependent disruption of occludin, without altering epithelial permeability.

Lapointe TK, Buret AG.

Am J Physiol Gastrointest Liver Physiol. 2012 Feb 1;302(3):G343-51. doi: 10.1152/ajpgi.00202.2011. Epub 2011 Dec 1.


L-Glutamine Enhances Tight Junction Integrity by Activating CaMK Kinase 2-AMP-Activated Protein Kinase Signaling in Intestinal Porcine Epithelial Cells.

Wang B, Wu Z, Ji Y, Sun K, Dai Z, Wu G.

J Nutr. 2016 Mar;146(3):501-8. doi: 10.3945/jn.115.224857. Epub 2016 Feb 10.


Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinase-dependent mechanism.

Pinton P, Braicu C, Nougayrede JP, Laffitte J, Taranu I, Oswald IP.

J Nutr. 2010 Nov;140(11):1956-62. doi: 10.3945/jn.110.123919. Epub 2010 Sep 22.


Serine proteases decrease intestinal epithelial ion permeability by activation of protein kinase Czeta.

Swystun VA, Renaux B, Moreau F, Wen S, Peplowski MA, Hollenberg MD, MacNaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G60-70. doi: 10.1152/ajpgi.00096.2009. Epub 2009 May 21.


Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-α on tight junction proteins and signaling pathways in intestinal epithelial cells.

Fischer A, Gluth M, Pape UF, Wiedenmann B, Theuring F, Baumgart DC.

Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1;304(11):G970-9. doi: 10.1152/ajpgi.00183.2012. Epub 2013 Mar 28.


Extracellular Mg(2+) regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylation.

Ikari A, Kinjo K, Atomi K, Sasaki Y, Yamazaki Y, Sugatani J.

Biochim Biophys Acta. 2010 Mar;1798(3):415-21. doi: 10.1016/j.bbamem.2009.11.005. Epub 2009 Nov 13.


Early Activation of MAPK p44/42 Is Partially Involved in DON-Induced Disruption of the Intestinal Barrier Function and Tight Junction Network.

Springler A, Hessenberger S, Schatzmayr G, Mayer E.

Toxins (Basel). 2016 Sep 8;8(9). pii: E264. doi: 10.3390/toxins8090264.


Decorin Prevents Retinal Pigment Epithelial Barrier Breakdown Under Diabetic Conditions by Suppressing p38 MAPK Activation.

Wang S, Du S, Wu Q, Hu J, Li T.

Invest Ophthalmol Vis Sci. 2015 May;56(5):2971-9. doi: 10.1167/iovs.14-15874.


Amelioration of hypoxia and LPS-induced intestinal epithelial barrier dysfunction by emodin through the suppression of the NF-κB and HIF-1α signaling pathways.

Lei Q, Qiang F, Chao D, Di W, Guoqian Z, Bo Y, Lina Y.

Int J Mol Med. 2014 Dec;34(6):1629-39. doi: 10.3892/ijmm.2014.1965. Epub 2014 Oct 13.


Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function.

Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR.

J Cell Biol. 2011 May 2;193(3):565-82. doi: 10.1083/jcb.201010065.


Claudins regulate the intestinal barrier in response to immune mediators.

Kinugasa T, Sakaguchi T, Gu X, Reinecker HC.

Gastroenterology. 2000 Jun;118(6):1001-11.


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