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Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability.

Bochman ML, Bell SP, Schwacha A.

Mol Cell Biol. 2008 Oct;28(19):5865-73. doi: 10.1128/MCB.00161-08. Epub 2008 Jul 28.


The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.

Bochman ML, Schwacha A.

Nucleic Acids Res. 2010 Oct;38(18):6078-88. doi: 10.1093/nar/gkq422. Epub 2010 May 19.


In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.

Evrin C, Fernández-Cid A, Zech J, Herrera MC, Riera A, Clarke P, Brill S, Lurz R, Speck C.

Nucleic Acids Res. 2013 Mar 1;41(5):3162-72. doi: 10.1093/nar/gkt043. Epub 2013 Feb 1.


Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

Davey MJ, Indiani C, O'Donnell M.

J Biol Chem. 2003 Feb 14;278(7):4491-9. Epub 2002 Dec 11.


The Mcm complex: unwinding the mechanism of a replicative helicase.

Bochman ML, Schwacha A.

Microbiol Mol Biol Rev. 2009 Dec;73(4):652-83. doi: 10.1128/MMBR.00019-09. Review.


Functional conservation of beta-hairpin DNA binding domains in the Mcm protein of Methanobacterium thermoautotrophicum and the Mcm5 protein of Saccharomyces cerevisiae.

Leon RP, Tecklenburg M, Sclafani RA.

Genetics. 2008 Aug;179(4):1757-68. doi: 10.1534/genetics.108.088690. Epub 2008 Jul 27.


ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes.

Stead BE, Sorbara CD, Brandl CJ, Davey MJ.

J Mol Biol. 2009 Aug 14;391(2):301-13. doi: 10.1016/j.jmb.2009.06.038. Epub 2009 Jun 21.


The eukaryotic Mcm2-7 replicative helicase.

Vijayraghavan S, Schwacha A.

Subcell Biochem. 2012;62:113-34. doi: 10.1007/978-94-007-4572-8_7. Review.


An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

Fernández-Cid A, Riera A, Tognetti S, Herrera MC, Samel S, Evrin C, Winkler C, Gardenal E, Uhle S, Speck C.

Mol Cell. 2013 May 23;50(4):577-88. doi: 10.1016/j.molcel.2013.03.026. Epub 2013 Apr 18.


A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA.

Samel SA, Fernández-Cid A, Sun J, Riera A, Tognetti S, Herrera MC, Li H, Speck C.

Genes Dev. 2014 Aug 1;28(15):1653-66. doi: 10.1101/gad.242404.114.


Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex.

You Z, Ishimi Y, Masai H, Hanaoka F.

J Biol Chem. 2002 Nov 8;277(45):42471-9. Epub 2002 Aug 30.


Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.

Randell JC, Bowers JL, Rodríguez HK, Bell SP.

Mol Cell. 2006 Jan 6;21(1):29-39.


Mcm subunits can assemble into two different active unwinding complexes.

Kanter DM, Bruck I, Kaplan DL.

J Biol Chem. 2008 Nov 7;283(45):31172-82. doi: 10.1074/jbc.M804686200. Epub 2008 Sep 17.


The effects of oligomerization on Saccharomyces cerevisiae Mcm4/6/7 function.

Ma X, Stead BE, Rezvanpour A, Davey MJ.

BMC Biochem. 2010 Sep 22;11:37. doi: 10.1186/1471-2091-11-37.


Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.

Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF.

Cell. 2009 Nov 13;139(4):719-30. doi: 10.1016/j.cell.2009.10.015. Epub 2009 Nov 5.


Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.

Ramer MD, Suman ES, Richter H, Stanger K, Spranger M, Bieberstein N, Duncker BP.

J Biol Chem. 2013 May 24;288(21):14926-35. doi: 10.1074/jbc.M112.392910. Epub 2013 Apr 2.


Multiple Cdt1 molecules act at each origin to load replication-competent Mcm2-7 helicases.

Takara TJ, Bell SP.

EMBO J. 2011 Nov 1;30(24):4885-96. doi: 10.1038/emboj.2011.394.


Crystal structure of the hexameric replicative helicase RepA of plasmid RSF1010.

Niedenzu T, Röleke D, Bains G, Scherzinger E, Saenger W.

J Mol Biol. 2001 Feb 23;306(3):479-87.


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