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Items: 1 to 20 of 89

1.

Manipulating the metazoan mitochondrial genome with targeted restriction enzymes.

Xu H, DeLuca SZ, O'Farrell PH.

Science. 2008 Jul 25;321(5888):575-7. doi: 10.1126/science.1160226.

2.

Genetic mosaic analysis of a deleterious mitochondrial DNA mutation in Drosophila reveals novel aspects of mitochondrial regulation and function.

Chen Z, Qi Y, French S, Zhang G, Covian Garcia R, Balaban R, Xu H.

Mol Biol Cell. 2015 Feb 15;26(4):674-84. doi: 10.1091/mbc.E14-11-1513. Epub 2014 Dec 10.

3.

Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a 'differential multiple cleavage-site' model.

Bacman SR, Williams SL, Hernandez D, Moraes CT.

Gene Ther. 2007 Sep;14(18):1309-18. Epub 2007 Jun 28.

4.

False positive results of mitochondrial DNA depletion/deletion due to single nucleotide substitutions causing appearance of additional PvuII restriction sites.

Weglewska-Jurkiewicz A, Jakóbkiewicz-Banecka J, Pronicka E, Wegrzyn G.

Diagn Mol Pathol. 2007 Jun;16(2):116-20.

PMID:
17525683
5.

Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.

Tanaka M, Borgeld HJ, Zhang J, Muramatsu S, Gong JS, Yoneda M, Maruyama W, Naoi M, Ibi T, Sahashi K, Shamoto M, Fuku N, Kurata M, Yamada Y, Nishizawa K, Akao Y, Ohishi N, Miyabayashi S, Umemoto H, Muramatsu T, Furukawa K, Kikuchi A, Nakano I, Ozawa K, Yagi K.

J Biomed Sci. 2002;9(6 Pt 1):534-41.

PMID:
12372991
6.

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.

Bacman SR, Williams SL, Pinto M, Peralta S, Moraes CT.

Nat Med. 2013 Sep;19(9):1111-3. doi: 10.1038/nm.3261. Epub 2013 Aug 4.

7.

Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease.

Bacman SR, Williams SL, Duan D, Moraes CT.

Gene Ther. 2012 Nov;19(11):1101-6. doi: 10.1038/gt.2011.196. Epub 2011 Dec 1.

8.

Altering the balance between healthy and mutated mitochondrial DNA.

Smith PM, Lightowlers RN.

J Inherit Metab Dis. 2011 Apr;34(2):309-13. doi: 10.1007/s10545-010-9122-6. Epub 2010 May 27. Review.

PMID:
20506041
9.

Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease.

Srivastava S, Moraes CT.

Hum Mol Genet. 2001 Dec 15;10(26):3093-9.

PMID:
11751691
10.

Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes.

Alexeyev MF, Venediktova N, Pastukh V, Shokolenko I, Bonilla G, Wilson GL.

Gene Ther. 2008 Apr;15(7):516-23. doi: 10.1038/sj.gt.2008.11. Epub 2008 Feb 7.

PMID:
18256697
11.

Animal models of mitochondrial DNA transactions in disease and ageing.

Oliveira MT, Garesse R, Kaguni LS.

Exp Gerontol. 2010 Aug;45(7-8):489-502. doi: 10.1016/j.exger.2010.01.019. Epub 2010 Feb 1. Review.

12.

Restriction fragment analysis as a source of error in detection of heteroplasmic mtDNA mutations.

Finnilä S, Hassinen IE, Majamaa K.

Mutat Res. 1999 Aug;406(2-4):109-14.

PMID:
10479727
13.

Mitochondrial DNA remains intact during Drosophila aging, but the levels of mitochondrial transcripts are significantly reduced.

Calleja M, Peña P, Ugalde C, Ferreiro C, Marco R, Garesse R.

J Biol Chem. 1993 Sep 5;268(25):18891-7.

14.

Experimental evidence supports a sex-specific selective sieve in mitochondrial genome evolution.

Innocenti P, Morrow EH, Dowling DK.

Science. 2011 May 13;332(6031):845-8. doi: 10.1126/science.1201157.

15.

Single Nucleotides in the mtDNA Sequence Modify Mitochondrial Molecular Function and Are Associated with Sex-Specific Effects on Fertility and Aging.

Camus MF, Wolf JB, Morrow EH, Dowling DK.

Curr Biol. 2015 Oct 19;25(20):2717-22. doi: 10.1016/j.cub.2015.09.012. Epub 2015 Oct 8.

16.

A cytoplasmic suppressor of a nuclear mutation affecting mitochondrial functions in Drosophila.

Chen S, Oliveira MT, Sanz A, Kemppainen E, Fukuoh A, Schlicht B, Kaguni LS, Jacobs HT.

Genetics. 2012 Oct;192(2):483-93. doi: 10.1534/genetics.112.143719. Epub 2012 Jul 30.

17.

Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila.

Humphrey DM, Parsons RB, Ludlow ZN, Riemensperger T, Esposito G, Verstreken P, Jacobs HT, Birman S, Hirth F.

Hum Mol Genet. 2012 Jun 15;21(12):2698-712. doi: 10.1093/hmg/dds096. Epub 2012 Mar 7.

PMID:
22398207
18.

Mitochondrial DNA mutations and depletion in pediatric medicine.

Spinazzola A.

Semin Fetal Neonatal Med. 2011 Aug;16(4):190-6. doi: 10.1016/j.siny.2011.04.011. Epub 2011 Jun 8. Review.

PMID:
21652274
19.

Utility of array CGH in molecular diagnosis of mitochondrial disorders.

Wang J, Rakhade M.

Methods Mol Biol. 2012;837:301-12. doi: 10.1007/978-1-61779-504-6_20.

PMID:
22215556
20.

Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease.

Bayona-Bafaluy MP, Blits B, Battersby BJ, Shoubridge EA, Moraes CT.

Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14392-7. Epub 2005 Sep 22.

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