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The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins.

Rueda P, Balabanian K, Lagane B, Staropoli I, Chow K, Levoye A, Laguri C, Sadir R, Delaunay T, Izquierdo E, Pablos JL, Lendinez E, Caruz A, Franco D, Baleux F, Lortat-Jacob H, Arenzana-Seisdedos F.

PLoS One. 2008 Jul 2;3(7):e2543. doi: 10.1371/journal.pone.0002543.


The novel CXCL12gamma isoform encodes an unstructured cationic domain which regulates bioactivity and interaction with both glycosaminoglycans and CXCR4.

Laguri C, Sadir R, Rueda P, Baleux F, Gans P, Arenzana-Seisdedos F, Lortat-Jacob H.

PLoS One. 2007 Oct 31;2(10):e1110.


Developmental expression profile of the CXCL12gamma isoform: insights into its tissue-specific role.

Franco D, Rueda P, Lendínez E, Arenzana-Seisdedos F, Caruz A.

Anat Rec (Hoboken). 2009 Jun;292(6):891-901. doi: 10.1002/ar.20899.


Relationships between glycosaminoglycan and receptor binding sites in chemokines-the CXCL12 example.

Laguri C, Arenzana-Seisdedos F, Lortat-Jacob H.

Carbohydr Res. 2008 Aug 11;343(12):2018-23. doi: 10.1016/j.carres.2008.01.047. Epub 2008 Feb 20. Review.


CXCL12γ isoform is expressed on endothelial and dendritic cells in rheumatoid arthritis synovium and regulates T cell activation.

Santiago B, Izquierdo E, Rueda P, Del Rey MJ, Criado G, Usategui A, Arenzana-Seisdedos F, Pablos JL.

Arthritis Rheum. 2012 Feb;64(2):409-17. doi: 10.1002/art.33345.


Heparan sulfate differentially controls CXCL12α- and CXCL12γ-mediated cell migration through differential presentation to their receptor CXCR4.

Connell BJ, Sadir R, Baleux F, Laguri C, Kleman JP, Luo L, Arenzana-Seisdedos F, Lortat-Jacob H.

Sci Signal. 2016 Nov 1;9(452):ra107.


Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine.

Amara A, Lorthioir O, Valenzuela A, Magerus A, Thelen M, Montes M, Virelizier JL, Delepierre M, Baleux F, Lortat-Jacob H, Arenzana-Seisdedos F.

J Biol Chem. 1999 Aug 20;274(34):23916-25.


The potent anti-HIV activity of CXCL12gamma correlates with efficient CXCR4 binding and internalization.

Altenburg JD, Jin Q, Alkhatib B, Alkhatib G.

J Virol. 2010 Mar;84(5):2563-72. doi: 10.1128/JVI.00342-09. Epub 2009 Dec 16.


Citrullination of CXCL12 differentially reduces CXCR4 and CXCR7 binding with loss of inflammatory and anti-HIV-1 activity via CXCR4.

Struyf S, Noppen S, Loos T, Mortier A, Gouwy M, Verbeke H, Huskens D, Luangsay S, Parmentier M, Geboes K, Schols D, Van Damme J, Proost P.

J Immunol. 2009 Jan 1;182(1):666-74.


CXCL12 is displayed by rheumatoid endothelial cells through its basic amino-terminal motif on heparan sulfate proteoglycans.

Santiago B, Baleux F, Palao G, Gutiérrez-Cañas I, Ramírez JC, Arenzana-Seisdedos F, Pablos JL.

Arthritis Res Ther. 2006;8(2):R43. Epub 2006 Feb 3.


Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events.

Gouwy M, Struyf S, Noppen S, Schutyser E, Springael JY, Parmentier M, Proost P, Van Damme J.

Mol Pharmacol. 2008 Aug;74(2):485-95. doi: 10.1124/mol.108.045146. Epub 2008 May 9.


Homeostatic and tissue reparation defaults in mice carrying selective genetic invalidation of CXCL12/proteoglycan interactions.

Rueda P, Richart A, Récalde A, Gasse P, Vilar J, Guérin C, Lortat-Jacob H, Vieira P, Baleux F, Chretien F, Arenzana-Seisdedos F, Silvestre JS.

Circulation. 2012 Oct 9;126(15):1882-95. doi: 10.1161/CIRCULATIONAHA.112.113290. Epub 2012 Oct 3.


Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus.

Vanheule V, Vervaeke P, Mortier A, Noppen S, Gouwy M, Snoeck R, Andrei G, Van Damme J, Liekens S, Proost P.

Biochem Pharmacol. 2016 Jan 15;100:73-85. doi: 10.1016/j.bcp.2015.11.001. Epub 2015 Nov 10.


Contribution of the putative heparan sulfate-binding motif BBXB of RANTES to transendothelial migration.

Ali S, Fritchley SJ, Chaffey BT, Kirby JA.

Glycobiology. 2002 Sep;12(9):535-43.


Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines.

Proudfoot AE, Handel TM, Johnson Z, Lau EK, LiWang P, Clark-Lewis I, Borlat F, Wells TN, Kosco-Vilbois MH.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1885-90. Epub 2003 Feb 5.


Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands.

Zabel BA, Wang Y, Lewén S, Berahovich RD, Penfold ME, Zhang P, Powers J, Summers BC, Miao Z, Zhao B, Jalili A, Janowska-Wieczorek A, Jaen JC, Schall TJ.

J Immunol. 2009 Sep 1;183(5):3204-11. doi: 10.4049/jimmunol.0900269. Epub 2009 Jul 29.


Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12.

O'Boyle G, Mellor P, Kirby JA, Ali S.

FASEB J. 2009 Nov;23(11):3906-16. doi: 10.1096/fj.09-134643. Epub 2009 Aug 10.


Different affinities of glycosaminoglycan oligosaccharides for monomeric and dimeric interleukin-8: a model for chemokine regulation at inflammatory sites.

Goger B, Halden Y, Rek A, Mösl R, Pye D, Gallagher J, Kungl AJ.

Biochemistry. 2002 Feb 5;41(5):1640-6.


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