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Items: 1 to 20 of 178

1.

The IkappaB kinase complex: master regulator of NF-kappaB signaling.

Solt LA, May MJ.

Immunol Res. 2008;42(1-3):3-18. doi: 10.1007/s12026-008-8025-1. Review.

2.

NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.

Solt LA, Madge LA, May MJ.

J Biol Chem. 2009 Oct 2;284(40):27596-608. doi: 10.1074/jbc.M109.047563. Epub 2009 Aug 7.

3.

Regulation and function of IKK and IKK-related kinases.

Häcker H, Karin M.

Sci STKE. 2006 Oct 17;2006(357):re13. Review.

PMID:
17047224
4.

Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta.

Solt LA, Madge LA, Orange JS, May MJ.

J Biol Chem. 2007 Mar 23;282(12):8724-33. Epub 2007 Jan 23.

5.

Novel non-peptide small molecules preventing IKKβ/NEMO association inhibit NF-κB activation in LPS-stimulated J774 macrophages.

De Falco F, Di Giovanni C, Cerchia C, De Stefano D, Capuozzo A, Irace C, Iuvone T, Santamaria R, Carnuccio R, Lavecchia A.

Biochem Pharmacol. 2016 Mar 15;104:83-94. doi: 10.1016/j.bcp.2016.01.008. Epub 2016 Jan 14.

PMID:
26776306
6.

A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity.

Leotoing L, Chereau F, Baron S, Hube F, Valencia HJ, Bordereaux D, Demmers JA, Strouboulis J, Baud V.

J Biol Chem. 2011 Sep 16;286(37):32277-88. doi: 10.1074/jbc.M111.236448. Epub 2011 Jul 22.

7.

IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.

Adli M, Merkhofer E, Cogswell P, Baldwin AS.

PLoS One. 2010 Feb 25;5(2):e9428. doi: 10.1371/journal.pone.0009428.

8.

Aberrant IKKα and IKKβ cooperatively activate NF-κB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer.

Nottingham LK, Yan CH, Yang X, Si H, Coupar J, Bian Y, Cheng TF, Allen C, Arun P, Gius D, Dang L, Van Waes C, Chen Z.

Oncogene. 2014 Feb 27;33(9):1135-47. doi: 10.1038/onc.2013.49. Epub 2013 Mar 4.

9.

Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A.

Grover A, Shandilya A, Punetha A, Bisaria VS, Sundar D.

BMC Genomics. 2010 Dec 2;11 Suppl 4:S25. doi: 10.1186/1471-2164-11-S4-S25.

12.

A20-mediated negative regulation of canonical NF-κB signaling pathway.

Pujari R, Hunte R, Khan WN, Shembade N.

Immunol Res. 2013 Dec;57(1-3):166-71. doi: 10.1007/s12026-013-8463-2. Review.

PMID:
24242761
13.

Noncanonical NF-κB signaling is limited by classical NF-κB activity.

Gray CM, Remouchamps C, McCorkell KA, Solt LA, Dejardin E, Orange JS, May MJ.

Sci Signal. 2014 Feb 4;7(311):ra13. doi: 10.1126/scisignal.2004557.

14.

The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis.

Dai S, Hirayama T, Abbas S, Abu-Amer Y.

J Biol Chem. 2004 Sep 3;279(36):37219-22. Epub 2004 Jul 13.

15.

Beyond NF-κB activation: nuclear functions of IκB kinase α.

Huang WC, Hung MC.

J Biomed Sci. 2013 Jan 23;20:3. doi: 10.1186/1423-0127-20-3. Review.

16.

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.

Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M.

J Exp Med. 1999 Jun 7;189(11):1839-45.

17.

Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.

Lam LT, Davis RE, Ngo VN, Lenz G, Wright G, Xu W, Zhao H, Yu X, Dang L, Staudt LM.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20798-803. doi: 10.1073/pnas.0806491106. Epub 2008 Dec 22.

18.

SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression.

Tai DJ, Su CC, Ma YL, Lee EH.

J Biol Chem. 2009 Feb 13;284(7):4073-89. doi: 10.1074/jbc.M805055200. Epub 2008 Dec 16.

19.

Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice.

Tang Y, Reay DP, Salay MN, Mi MY, Clemens PR, Guttridge DC, Robbins PD, Huard J, Wang B.

Gene Ther. 2010 Dec;17(12):1476-83. doi: 10.1038/gt.2010.110. Epub 2010 Aug 19.

20.

Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/NEMO and inhibiting IKKβ kinase activity.

You DJ, Park CR, Furlong M, Koo O, Lee C, Ahn C, Seong JY, Hwang JI.

Cell Signal. 2015 Nov;27(11):2173-81. doi: 10.1016/j.cellsig.2015.08.012. Epub 2015 Aug 18.

PMID:
26296658

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