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Items: 1 to 20 of 308

1.

Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-alpha and IL-6 inhibitors.

Bharate SB, Mahajan TR, Gole YR, Nambiar M, Matan TT, Kulkarni-Almeida A, Balachandran S, Junjappa H, Balakrishnan A, Vishwakarma RA.

Bioorg Med Chem. 2008 Aug 1;16(15):7167-76. doi: 10.1016/j.bmc.2008.06.042.

PMID:
18625560
2.

FR167653, a potent suppressant of interleukin-1 and tumor necrosis factor-alpha production, ameliorates colonic lesions in experimentally induced acute colitis.

Blandino II, Otaka M, Jin M, Komatsu K, Odashima M, Konishi N, Sato T, Kato S, Watanabe S.

J Gastroenterol Hepatol. 2001 Oct;16(10):1105-11.

PMID:
11686836
3.
4.

Synthesis and biological evaluation of nitrogen-containing benzophenone analogues as TNF-alpha and IL-6 inhibitors with antioxidant activity.

Bandgar BP, Patil SA, Totre JV, Korbad BL, Gacche RN, Hote BS, Jalde SS, Chavan HV.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2292-6. doi: 10.1016/j.bmcl.2010.02.001.

PMID:
20207143
5.

Phosphodiesterase inhibitors. Part 2: design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity.

Ochiai K, Ando N, Iwase K, Kishi T, Fukuchi K, Ohinata A, Zushi H, Yasue T, Adams DR, Kohno Y.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5451-6. doi: 10.1016/j.bmcl.2011.06.118.

PMID:
21764304
6.

Imidazole inhibitors of cytokine release: probing substituents in the 2 position.

Laufer SA, Striegel HG, Wagner GK.

J Med Chem. 2002 Oct 10;45(21):4695-705.

PMID:
12361396
7.

Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses.

Allen SH, Johns BA, Gudmundsson KS, Freeman GA, Boyd FL Jr, Sexton CH, Selleseth DW, Creech KL, Moniri KR.

Bioorg Med Chem. 2006 Feb 15;14(4):944-54.

PMID:
16213142
8.

Synthesis and biological evaluation of beta-chloro vinyl chalcones as inhibitors of TNF-alpha and IL-6 with antimicrobial activity.

Bandgar BP, Patil SA, Korbad BL, Nile SH, Khobragade CN.

Eur J Med Chem. 2010 Jun;45(6):2629-33. doi: 10.1016/j.ejmech.2010.01.050.

PMID:
20171758
9.

Synthesis of novel 3,5-diaryl pyrazole derivatives using combinatorial chemistry as inhibitors of tyrosinase as well as potent anticancer, anti-inflammatory agents.

Bandgar BP, Totre JV, Gawande SS, Khobragade CN, Warangkar SC, Kadam PD.

Bioorg Med Chem. 2010 Aug 15;18(16):6149-55. doi: 10.1016/j.bmc.2010.06.046.

PMID:
20638287
10.

Synthesis and anti-inflammatory evaluation of novel mono-carbonyl analogues of curcumin in LPS-stimulated RAW 264.7 macrophages.

Zhao C, Cai Y, He X, Li J, Zhang L, Wu J, Zhao Y, Yang S, Li X, Li W, Liang G.

Eur J Med Chem. 2010 Dec;45(12):5773-80. doi: 10.1016/j.ejmech.2010.09.037.

PMID:
20934787
11.

Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.

Ali A, Thompson CF, Balkovec JM, Graham DW, Hammond ML, Quraishi N, Tata JR, Einstein M, Ge L, Harris G, Kelly TM, Mazur P, Pandit S, Santoro J, Sitlani A, Wang C, Williamson J, Miller DK, Thompson CM, Zaller DM, Forrest MJ, Carballo-Jane E, Luell S.

J Med Chem. 2004 May 6;47(10):2441-52.

PMID:
15115388
12.

Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.

Lin R, Connolly PJ, Lu Y, Chiu G, Li S, Yu Y, Huang S, Li X, Emanuel SL, Middleton SA, Gruninger RH, Adams M, Fuentes-Pesquera AR, Greenberger LM.

Bioorg Med Chem Lett. 2007 Aug 1;17(15):4297-302.

PMID:
17532631
13.

Synthesis and biological evaluation of a novel series of pyrazole chalcones as anti-inflammatory, antioxidant and antimicrobial agents.

Bandgar BP, Gawande SS, Bodade RG, Gawande NM, Khobragade CN.

Bioorg Med Chem. 2009 Dec 15;17(24):8168-73. doi: 10.1016/j.bmc.2009.10.035.

PMID:
19896853
14.

Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines.

Ahmed OM, Mohamed MA, Ahmed RR, Ahmed SA.

Eur J Med Chem. 2009 Sep;44(9):3519-23. doi: 10.1016/j.ejmech.2009.03.042.

PMID:
19398146
15.
16.

Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents.

Bandgar BP, Patil SA, Korbad BL, Biradar SC, Nile SN, Khobragade CN.

Eur J Med Chem. 2010 Jul;45(7):3223-7. doi: 10.1016/j.ejmech.2010.03.045.

PMID:
20430485
17.

Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity.

Biagini P, Biancalani C, Graziano A, Cesari N, Giovannoni MP, Cilibrizzi A, Dal Piaz V, Vergelli C, Crocetti L, Delcanale M, Armani E, Rizzi A, Puccini P, Gallo PM, Spinabelli D, Caruso P.

Bioorg Med Chem. 2010 May 15;18(10):3506-17. doi: 10.1016/j.bmc.2010.03.066.

PMID:
20413313
18.

Facile synthesis and in-vitro antitumor activity of some pyrazolo[3,4-b]pyridines and pyrazolo[1,5-a]pyrimidines linked to a thiazolo[3,2-a]benzimidazole moiety.

Abdel-Aziz HA, Saleh TS, El-Zahabi HS.

Arch Pharm (Weinheim). 2010 Jan;343(1):24-30. doi: 10.1002/ardp.200900082.

PMID:
19921685
19.

Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives.

Leal B, Afonso IF, Rodrigues CR, Abreu PA, Garrett R, Pinheiro LC, Azevedo AR, Borges JC, Vegi PF, Santos CC, da Silveira FC, Cabral LM, Frugulhetti IC, Bernardino AM, Santos DO, Castro HC.

Bioorg Med Chem. 2008 Sep 1;16(17):8196-204. doi: 10.1016/j.bmc.2008.07.035.

PMID:
18701299
20.

Tetrahydropyridine derivatives with inhibitory activity on the production of proinflammatory cytokines: part 3.

Nakao A, Ohkawa N, Nagasaki T, Kagari T, Doi H, Shimozato T, Ushiyama S, Aoki K.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4774-8. doi: 10.1016/j.bmcl.2010.06.122.

PMID:
20637613
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