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Ubiquitin over-expression promotes E6AP autodegradation and reactivation of the p53/MDM2 pathway in HeLa cells.

Crinelli R, Bianchi M, Menotta M, Carloni E, Giacomini E, Pennati M, Magnani M.

Mol Cell Biochem. 2008 Nov;318(1-2):129-45. doi: 10.1007/s11010-008-9864-8. Epub 2008 Jul 9.


MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.

Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W.

J Biol Chem. 2009 May 22;284(21):13987-4000. doi: 10.1074/jbc.M901758200. Epub 2009 Mar 25.


Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2.

Linares LK, Kiernan R, Triboulet R, Chable-Bessia C, Latreille D, Cuvier O, Lacroix M, Le Cam L, Coux O, Benkirane M.

Nat Cell Biol. 2007 Mar;9(3):331-8. Epub 2007 Feb 11.


Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells.

Duan W, Gao L, Wu X, Zhang Y, Otterson GA, Villalona-Calero MA.

Exp Cell Res. 2006 Oct 15;312(17):3370-8. Epub 2006 Jul 21.


Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism.

Dai MS, Shi D, Jin Y, Sun XX, Zhang Y, Grossman SR, Lu H.

J Biol Chem. 2006 Aug 25;281(34):24304-13. Epub 2006 Jun 27.


p53 Stabilization and accumulation induced by human vaccinia-related kinase 1.

Vega FM, Sevilla A, Lazo PA.

Mol Cell Biol. 2004 Dec;24(23):10366-80.


Ubiquitination and degradation of mutant p53.

Lukashchuk N, Vousden KH.

Mol Cell Biol. 2007 Dec;27(23):8284-95. Epub 2007 Oct 1.


Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination.

Nie L, Sasaki M, Maki CG.

J Biol Chem. 2007 May 11;282(19):14616-25. Epub 2007 Mar 19.


Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination.

Wang KS, Chen G, Shen HL, Li TT, Chen F, Wang QW, Wang ZQ, Han ZG, Zhang X.

PLoS One. 2011;6(8):e23571. doi: 10.1371/journal.pone.0023571. Epub 2011 Aug 24.


ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation.

Meulmeester E, Pereg Y, Shiloh Y, Jochemsen AG.

Cell Cycle. 2005 Sep;4(9):1166-70. Epub 2005 Sep 29. Review.


SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination.

Lee MH, Lee SW, Lee EJ, Choi SJ, Chung SS, Lee JI, Cho JM, Seol JH, Baek SH, Kim KI, Chiba T, Tanaka K, Bang OS, Chung CH.

Nat Cell Biol. 2006 Dec;8(12):1424-31. Epub 2006 Nov 5.


Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.

Saville MK, Sparks A, Xirodimas DP, Wardrop J, Stevenson LF, Bourdon JC, Woods YL, Lane DP.

J Biol Chem. 2004 Oct 1;279(40):42169-81. Epub 2004 Jul 26.


p53 ubiquitination: Mdm2 and beyond.

Brooks CL, Gu W.

Mol Cell. 2006 Feb 3;21(3):307-15. Review.


Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase.

Wang X, Zha M, Zhao X, Jiang P, Du W, Tam AY, Mei Y, Wu M.

Nat Commun. 2013;4:1551. doi: 10.1038/ncomms2533.


Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation.

Lindström MS, Jin A, Deisenroth C, White Wolf G, Zhang Y.

Mol Cell Biol. 2007 Feb;27(3):1056-68. Epub 2006 Nov 20.


Making sense of ubiquitin ligases that regulate p53.

Jain AK, Barton MC.

Cancer Biol Ther. 2010 Oct 1;10(7):665-72. Epub 2010 Oct 1. Review.


Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells.

Brew CT, Aronchik I, Hsu JC, Sheen JH, Dickson RB, Bjeldanes LF, Firestone GL.

Int J Cancer. 2006 Feb 15;118(4):857-68.


Dual-site regulation of MDM2 E3-ubiquitin ligase activity.

Wallace M, Worrall E, Pettersson S, Hupp TR, Ball KL.

Mol Cell. 2006 Jul 21;23(2):251-63.

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