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Items: 1 to 20 of 67

1.

IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver.

Luedde T, Heinrichsdorff J, de Lorenzi R, De Vos R, Roskams T, Pasparakis M.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9733-8. doi: 10.1073/pnas.0800198105. Epub 2008 Jul 7.

2.

Epithelial NEMO links innate immunity to chronic intestinal inflammation.

Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M.

Nature. 2007 Mar 29;446(7135):557-61. Epub 2007 Mar 14.

3.

Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure.

Ehlken H, Kondylis V, Heinrichsdorff J, Ochoa-Callejero L, Roskams T, Pasparakis M.

PLoS One. 2011;6(10):e25942. doi: 10.1371/journal.pone.0025942. Epub 2011 Oct 14.

4.

Regulation and function of IKK and IKK-related kinases.

Häcker H, Karin M.

Sci STKE. 2006 Oct 17;2006(357):re13. Review.

PMID:
17047224
5.

Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity.

Correa RG, Matsui T, Tergaonkar V, Rodriguez-Esteban C, Izpisua-Belmonte JC, Verma IM.

Curr Biol. 2005 Jul 26;15(14):1291-5.

6.

Vanishing bile duct syndrome: a possible mechanism for intrahepatic cholestasis in Hodgkin's lymphoma.

Hubscher SG, Lumley MA, Elias E.

Hepatology. 1993 Jan;17(1):70-7.

PMID:
7678577
7.

Validation of the anti-inflammatory properties of small-molecule IkappaB Kinase (IKK)-2 inhibitors by comparison with adenoviral-mediated delivery of dominant-negative IKK1 and IKK2 in human airways smooth muscle.

Catley MC, Sukkar MB, Chung KF, Jaffee B, Liao SM, Coyle AJ, Haddad el-B, Barnes PJ, Newton R.

Mol Pharmacol. 2006 Aug;70(2):697-705. Epub 2006 May 10.

8.

Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.

Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner DA, Manns MP, Pasparakis M, Trautwein C.

J Clin Invest. 2005 Apr;115(4):849-59. Epub 2005 Mar 17.

9.

Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury.

Beraza N, Lüdde T, Assmus U, Roskams T, Vander Borght S, Trautwein C.

Gastroenterology. 2007 Jun;132(7):2504-17. Epub 2007 Apr 6.

PMID:
17570222
10.
11.

p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure.

Heinrichsdorff J, Luedde T, Perdiguero E, Nebreda AR, Pasparakis M.

EMBO Rep. 2008 Oct;9(10):1048-54. doi: 10.1038/embor.2008.149. Epub 2008 Aug 15.

12.

TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2.

Pasparakis M, Courtois G, Hafner M, Schmidt-Supprian M, Nenci A, Toksoy A, Krampert M, Goebeler M, Gillitzer R, Israel A, Krieg T, Rajewsky K, Haase I.

Nature. 2002 Jun 20;417(6891):861-6.

PMID:
12075355
13.

Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS.

Dajani R, Sanlioglu S, Zhang Y, Li Q, Monick MM, Lazartigues E, Eggleston T, Davisson RL, Hunninghake GW, Engelhardt JF.

Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G242-52. Epub 2006 Aug 24.

14.

Mature T cells depend on signaling through the IKK complex.

Schmidt-Supprian M, Courtois G, Tian J, Coyle AJ, Israël A, Rajewsky K, Pasparakis M.

Immunity. 2003 Sep;19(3):377-89.

15.

IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB.

Schmid JA, Birbach A.

Cytokine Growth Factor Rev. 2008 Apr;19(2):157-65. doi: 10.1016/j.cytogfr.2008.01.006. Epub 2008 Mar 4. Review.

PMID:
18308615
16.

Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines.

Saito N, Courtois G, Chiba A, Yamamoto N, Nitta T, Hironaka N, Rowe M, Yamamoto N, Yamaoka S.

J Biol Chem. 2003 Nov 21;278(47):46565-75. Epub 2003 Sep 10.

17.

Destructive intrahepatic bile duct diseases.

Desmet VJ.

Recenti Prog Med. 1990 Jun;81(6):392-8. Review.

PMID:
2251446
18.

Pathology and pathogenesis of intrahepatic bile duct loss.

Nakanuma Y, Tsuneyama K, Harada K.

J Hepatobiliary Pancreat Surg. 2001;8(4):303-15. Review.

PMID:
11521175
19.

IkappaB kinase signaling is essential for maintenance of mature B cells.

Pasparakis M, Schmidt-Supprian M, Rajewsky K.

J Exp Med. 2002 Sep 16;196(6):743-52.

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