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Items: 1 to 20 of 157

1.

Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice.

Akhtar RS, Klocke BJ, Strasser A, Roth KA.

J Histochem Cytochem. 2008 Oct;56(10):921-7. doi: 10.1369/jhc.2008.951749.

2.

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis.

Coultas L, Bouillet P, Loveland KL, Meachem S, Perlman H, Adams JM, Strasser A.

EMBO J. 2005 Nov 16;24(22):3963-73.

3.

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells.

O'Reilly LA, Cullen L, Visvader J, Lindeman GJ, Print C, Bath ML, Huang DC, Strasser A.

Am J Pathol. 2000 Aug;157(2):449-61.

4.

The Bcl-2 homology domain 3 (BH3)-only proteins Bim and bid are functionally active and restrained by anti-apoptotic Bcl-2 family proteins in healthy liver.

Kodama T, Hikita H, Kawaguchi T, Saito Y, Tanaka S, Shigekawa M, Shimizu S, Li W, Miyagi T, Kanto T, Hiramatsu N, Tatsumi T, Takehara T.

J Biol Chem. 2013 Oct 18;288(42):30009-18. doi: 10.1074/jbc.M112.443093.

5.
6.

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis.

Hutcheson J, Scatizzi JC, Bickel E, Brown NJ, Bouillet P, Strasser A, Perlman H.

J Exp Med. 2005 Jun 20;201(12):1949-60.

7.

Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim.

Zimmermann AK, Loucks FA, Le SS, Butts BD, Florez-McClure ML, Bouchard RJ, Heidenreich KA, Linseman DA.

J Neurochem. 2005 Jul;94(1):22-36.

8.

Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways.

Zaidi AU, D'Sa-Eipper C, Brenner J, Kuida K, Zheng TS, Flavell RA, Rakic P, Roth KA.

J Neurosci. 2001 Jan 1;21(1):169-75.

9.

Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases.

Hughes P, Bouillet P, Strasser A.

Curr Dir Autoimmun. 2006;9:74-94. Review.

PMID:
16394656
10.
11.
12.

Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.

Labi V, Woess C, Tuzlak S, Erlacher M, Bouillet P, Strasser A, Tzankov A, Villunger A.

Blood. 2014 Apr 24;123(17):2652-62. doi: 10.1182/blood-2013-11-537217.

13.

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.

Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL.

Blood. 2006 Sep 1;108(5):1461-8.

14.

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice.

Motoyama N, Wang F, Roth KA, Sawa H, Nakayama K, Nakayama K, Negishi I, Senju S, Zhang Q, Fujii S, et al.

Science. 1995 Mar 10;267(5203):1506-10.

PMID:
7878471
15.

A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity.

Ponassi R, Biasotti B, Tomati V, Bruno S, Poggi A, Malacarne D, Cimoli G, Salis A, Pozzi S, Miglino M, Damonte G, Cozzini P, Spyrakis F, Campanini B, Bagnasco L, Castagnino N, Tortolina L, Mumot A, Frassoni F, Daga A, Cilli M, Piccardi F, Monfardini I, Perugini M, Zoppoli G, D'Arrigo C, Pesenti R, Parodi S.

Cell Cycle. 2008 Oct;7(20):3211-24. Erratum in: Cell Cycle. 2012 Oct 1;11(19):3703. Spyraki, Francesca [corrected to Spyrakis, Francesca].

PMID:
18843207
16.

BH3-only protein Bim inhibits activity of antiapoptotic members of Bcl-2 family when expressed in yeast.

Juhásová B, Mentel M, Bhatia-Kiššová I, Zeman I, Kolarov J, Forte M, Polčic P.

FEBS Lett. 2011 Sep 2;585(17):2709-13. doi: 10.1016/j.febslet.2011.07.027.

17.

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.

Marani M, Tenev T, Hancock D, Downward J, Lemoine NR.

Mol Cell Biol. 2002 Jun;22(11):3577-89.

18.

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7.

Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL.

Int Immunol. 2009 Jun;21(6):715-25. doi: 10.1093/intimm/dxp043.

19.

The pro-apoptotic BH3-only protein Bim regulates cell cycle progression of hematopoietic progenitors during megakaryopoiesis.

Kozuma Y, Ninomiya H, Murata S, Kono T, Mukai HY, Kojima H.

J Thromb Haemost. 2010 May;8(5):1088-97. doi: 10.1111/j.1538-7836.2010.03785.x.

20.

Mcl-1 antagonizes Bax/Bak to promote effector CD4(+) and CD8(+) T-cell responses.

Tripathi P, Koss B, Opferman JT, Hildeman DA.

Cell Death Differ. 2013 Aug;20(8):998-1007. doi: 10.1038/cdd.2013.25.

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