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TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.

Takedatsu H, Michelsen KS, Wei B, Landers CJ, Thomas LS, Dhall D, Braun J, Targan SR.

Gastroenterology. 2008 Aug;135(2):552-67. doi: 10.1053/j.gastro.2008.04.037. Epub 2008 May 7.


Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.

Barrett R, Zhang X, Koon HW, Vu M, Chang JY, Yeager N, Nguyen MA, Michelsen KS, Berel D, Pothoulakis C, Targan SR, Shih DQ.

Am J Pathol. 2012 Feb;180(2):636-49. doi: 10.1016/j.ajpath.2011.10.026. Epub 2011 Dec 2.


Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes.

Papadakis KA, Zhu D, Prehn JL, Landers C, Avanesyan A, Lafkas G, Targan SR.

J Immunol. 2005 Apr 15;174(8):4985-90.


TL1A as a Potential Local Inducer of IL17A Expression in Colon Mucosa of Inflammatory Bowel Disease Patients.

Ślebioda TJ, Bojarska-Junak A, Stanisławowski M, Cyman M, Wierzbicki PM, Roliński J, Celiński K, Kmieć Z.

Scand J Immunol. 2015 Oct;82(4):352-60. doi: 10.1111/sji.12324.


TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease.

Kamada N, Hisamatsu T, Honda H, Kobayashi T, Chinen H, Takayama T, Kitazume MT, Okamoto S, Koganei K, Sugita A, Kanai T, Hibi T.

Inflamm Bowel Dis. 2010 Apr;16(4):568-75. doi: 10.1002/ibd.21124.


Role of TL1A and its receptor DR3 in two models of chronic murine ileitis.

Bamias G, Mishina M, Nyce M, Ross WG, Kollias G, Rivera-Nieves J, Pizarro TT, Cominelli F.

Proc Natl Acad Sci U S A. 2006 May 30;103(22):8441-6. Epub 2006 May 12.


1,25-dihydroxyvitamin D3 regulates the development of chronic colitis by modulating both T helper (Th)1 and Th17 activation.

Zhang H, Wu H, Liu L, Li H, Shih DQ, Zhang X.

APMIS. 2015 Jun;123(6):490-501. doi: 10.1111/apm.12378. Epub 2015 Apr 23.


Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease.

Bamias G, Martin C 3rd, Marini M, Hoang S, Mishina M, Ross WG, Sachedina MA, Friel CM, Mize J, Bickston SJ, Pizarro TT, Wei P, Cominelli F.

J Immunol. 2003 Nov 1;171(9):4868-74.


Berberine ameliorates chronic relapsing dextran sulfate sodium-induced colitis in C57BL/6 mice by suppressing Th17 responses.

Li YH, Xiao HT, Hu DD, Fatima S, Lin CY, Mu HX, Lee NP, Bian ZX.

Pharmacol Res. 2016 Aug;110:227-239. doi: 10.1016/j.phrs.2016.02.010. Epub 2016 Mar 9.


Tumor Necrosis Factor-like Cytokine TL1A and Its Receptors DR3 and DcR3: Important New Factors in Mucosal Homeostasis and Inflammation.

Siakavellas SI, Bamias G.

Inflamm Bowel Dis. 2015 Oct;21(10):2441-52. doi: 10.1097/MIB.0000000000000492. Review.


Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: therapeutic efficacy and possible mechanisms of action.

Yousef M, Pichyangkura R, Soodvilai S, Chatsudthipong V, Muanprasat C.

Pharmacol Res. 2012 Jul;66(1):66-79. doi: 10.1016/j.phrs.2012.03.013. Epub 2012 Mar 28.


Nicotine suppresses acute colitis and colonic tumorigenesis associated with chronic colitis in mice.

Hayashi S, Hamada T, Zaidi SF, Oshiro M, Lee J, Yamamoto T, Ishii Y, Sasahara M, Kadowaki M.

Am J Physiol Gastrointest Liver Physiol. 2014 Nov 15;307(10):G968-78. doi: 10.1152/ajpgi.00346.2013. Epub 2014 Sep 25.


Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation.

Prehn JL, Mehdizadeh S, Landers CJ, Luo X, Cha SC, Wei P, Targan SR.

Clin Immunol. 2004 Jul;112(1):66-77.


Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis.

Yin H, Li X, Zhang B, Liu T, Yuan B, Ni Q, Hu S, Gu H.

Immunology. 2013 Aug;139(4):494-502. doi: 10.1111/imm.12096.


Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis.

Wang H, Dong J, Shi P, Liu J, Zuo L, Li Y, Gong J, Gu L, Zhao J, Zhang L, Zhang W, Zhu W, Li N, Li J.

Immunology. 2015 Feb;144(2):254-62. doi: 10.1111/imm.12366.


Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis.

Sidhu-Varma M, Shih DQ, Targan SR.

Inflamm Bowel Dis. 2016 Mar;22(3):548-59. doi: 10.1097/MIB.0000000000000653.


Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein.

Nguyen DD, Maillard MH, Cotta-de-Almeida V, Mizoguchi E, Klein C, Fuss I, Nagler C, Mizoguchi A, Bhan AK, Snapper SB.

Gastroenterology. 2007 Oct;133(4):1188-97. Epub 2007 Jul 12.


P-selectin glycoprotein ligand-1 is needed for sequential recruitment of T-helper 1 (Th1) and local generation of Th17 T cells in dextran sodium sulfate (DSS) colitis.

Brown JB, Cheresh P, Zhang Z, Ryu H, Managlia E, Barrett TA.

Inflamm Bowel Dis. 2012 Feb;18(2):323-32. doi: 10.1002/ibd.21779.


HMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responses.

Michelsen KS, Wong MH, Ko B, Thomas LS, Dhall D, Targan SR.

Inflamm Bowel Dis. 2013 Jan;19(1):151-64. doi: 10.1002/ibd.22983.


Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production.

Siegmund B, Fantuzzi G, Rieder F, Gamboni-Robertson F, Lehr HA, Hartmann G, Dinarello CA, Endres S, Eigler A.

Am J Physiol Regul Integr Comp Physiol. 2001 Oct;281(4):R1264-73.

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