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Items: 1 to 20 of 290

1.

In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.

Kuriyama C, Kamiyama O, Ikeda K, Sanae F, Kato A, Adachi I, Imahori T, Takahata H, Okamoto T, Asano N.

Bioorg Med Chem. 2008 Aug 1;16(15):7330-6. doi: 10.1016/j.bmc.2008.06.026. Epub 2008 Jun 18.

PMID:
18595718
2.

Effect of five-membered sugar mimics on mammalian glycogen-degrading enzymes and various glucosidases.

Minami Y, Kuriyama C, Ikeda K, Kato A, Takebayashi K, Adachi I, Fleet GW, Kettawan A, Okamoto T, Asano N.

Bioorg Med Chem. 2008 Mar 15;16(6):2734-40. doi: 10.1016/j.bmc.2008.01.032. Epub 2008 Jan 26.

PMID:
18258441
3.

Biological properties of D- and L-1-deoxyazasugars.

Kato A, Kato N, Kano E, Adachi I, Ikeda K, Yu L, Okamoto T, Banba Y, Ouchi H, Takahata H, Asano N.

J Med Chem. 2005 Mar 24;48(6):2036-44.

PMID:
15771446
4.

Alpha-1-C-octyl-1-deoxynojirimycin as a pharmacological chaperone for Gaucher disease.

Yu L, Ikeda K, Kato A, Adachi I, Godin G, Compain P, Martin O, Asano N.

Bioorg Med Chem. 2006 Dec 1;14(23):7736-44. Epub 2006 Aug 21.

PMID:
16919960
5.

Homonojirimycin isomers and N-alkylated homonojirimycins: structural and conformational basis of inhibition of glycosidases.

Asano N, Nishida M, Kato A, Kizu H, Matsui K, Shimada Y, Itoh T, Baba M, Watson AA, Nash RJ, Lilley PM, Watkin DJ, Fleet GW.

J Med Chem. 1998 Jul 2;41(14):2565-71.

PMID:
9651160
6.

N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.

Asano N, Kizu H, Oseki K, Tomioka E, Matsui K, Okamoto M, Baba M.

J Med Chem. 1995 Jun 23;38(13):2349-56.

PMID:
7608901
7.

The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors.

Andersen B, Westergaard N.

Biochem J. 2002 Oct 15;367(Pt 2):443-50.

8.

Inhibition of glycogen breakdown by imino sugars in vitro and in vivo.

Andersson U, Reinkensmeier G, Butters TD, Dwek RA, Platt FM.

Biochem Pharmacol. 2004 Feb 15;67(4):697-705.

PMID:
14757169
9.

Evidence against glycogen cycling of gluconeogenic substrates in various liver preparations.

Fosgerau K, Breinholt J, McCormack JG, Westergaard N.

J Biol Chem. 2002 Aug 9;277(32):28648-55. Epub 2002 May 31.

10.

Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases.

Asano N, Oseki K, Kizu H, Matsui K.

J Med Chem. 1994 Oct 28;37(22):3701-6.

PMID:
7966130
11.
12.

Inhibition of glycogenolysis in primary rat hepatocytes by 1, 4-dideoxy-1,4-imino-D-arabinitol.

Andersen B, Rassov A, Westergaard N, Lundgren K.

Biochem J. 1999 Sep 15;342 Pt 3:545-50.

13.

Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin.

Luan Z, Higaki K, Aguilar-Moncayo M, Ninomiya H, Ohno K, García-Moreno MI, Ortiz Mellet C, García Fernández JM, Suzuki Y.

Chembiochem. 2009 Nov 23;10(17):2780-92. doi: 10.1002/cbic.200900442.

PMID:
19830760
14.

Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease.

Rountree JS, Butters TD, Wormald MR, Boomkamp SD, Dwek RA, Asano N, Ikeda K, Evinson EL, Nash RJ, Fleet GW.

ChemMedChem. 2009 Mar;4(3):378-92. doi: 10.1002/cmdc.200800350.

PMID:
19145603
15.

New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii.

Yasuda K, Kizu H, Yamashita T, Kameda Y, Kato A, Nash RJ, Fleet GW, Molyneux RJ, Asano N.

J Nat Prod. 2002 Feb;65(2):198-202.

PMID:
11858756
16.

Kinetic and functional characterization of 1,4-dideoxy-1, 4-imino-d-arabinitol: a potent inhibitor of glycogen phosphorylase with anti-hyperglyceamic effect in ob/ob mice.

Fosgerau K, Westergaard N, Quistorff B, Grunnet N, Kristiansen M, Lundgren K.

Arch Biochem Biophys. 2000 Aug 15;380(2):274-84.

PMID:
10933882
17.

Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease.

Sawkar AR, Cheng WC, Beutler E, Wong CH, Balch WE, Kelly JW.

Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15428-33. Epub 2002 Nov 14.

18.

Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases.

Lee JC, Francis S, Dutta D, Gupta V, Yang Y, Zhu JY, Tash JS, Schönbrunn E, Georg GI.

J Org Chem. 2012 Apr 6;77(7):3082-98. doi: 10.1021/jo202054g. Epub 2012 Mar 20.

19.

Alkaloids from the poisonous plant Ipomoea carnea: effects on intracellular lysosomal glycosidase activities in human lymphoblast cultures.

Ikeda K, Kato A, Adachi I, Haraguchi M, Asano N.

J Agric Food Chem. 2003 Dec 17;51(26):7642-6.

PMID:
14664522
20.

Miglustat (NB-DNJ) works as a chaperone for mutated acid beta-glucosidase in cells transfected with several Gaucher disease mutations.

Alfonso P, Pampín S, Estrada J, Rodríguez-Rey JC, Giraldo P, Sancho J, Pocoví M.

Blood Cells Mol Dis. 2005 Sep-Oct;35(2):268-76.

PMID:
16039881

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