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Items: 1 to 20 of 87


NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling.

McBride KL, Riley MF, Zender GA, Fitzgerald-Butt SM, Towbin JA, Belmont JW, Cole SE.

Hum Mol Genet. 2008 Sep 15;17(18):2886-93. doi: 10.1093/hmg/ddn187. Epub 2008 Jun 30.


NOTCH1 missense alleles associated with left ventricular outflow tract defects exhibit impaired receptor processing and defective EMT.

Riley MF, McBride KL, Cole SE.

Biochim Biophys Acta. 2011 Jan;1812(1):121-9. doi: 10.1016/j.bbadis.2010.10.002. Epub 2010 Oct 14.


Association of common variants in ERBB4 with congenital left ventricular outflow tract obstruction defects.

McBride KL, Zender GA, Fitzgerald-Butt SM, Seagraves NJ, Fernbach SD, Zapata G, Lewin M, Towbin JA, Belmont JW.

Birth Defects Res A Clin Mol Teratol. 2011 Mar;91(3):162-8. doi: 10.1002/bdra.20764. Epub 2011 Feb 2.


Linkage analysis of left ventricular outflow tract malformations (aortic valve stenosis, coarctation of the aorta, and hypoplastic left heart syndrome).

McBride KL, Zender GA, Fitzgerald-Butt SM, Koehler D, Menesses-Diaz A, Fernbach S, Lee K, Towbin JA, Leal S, Belmont JW.

Eur J Hum Genet. 2009 Jun;17(6):811-9. doi: 10.1038/ejhg.2008.255. Epub 2009 Jan 14.


A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.

Cordle J, Johnson S, Tay JZ, Roversi P, Wilkin MB, de Madrid BH, Shimizu H, Jensen S, Whiteman P, Jin B, Redfield C, Baron M, Lea SM, Handford PA.

Nat Struct Mol Biol. 2008 Aug;15(8):849-57. doi: 10.1038/nsmb.1457. Epub 2008 Jul 27.


Jagged1 (JAG1) mutations in patients with tetralogy of Fallot or pulmonic stenosis.

Bauer RC, Laney AO, Smith R, Gerfen J, Morrissette JJ, Woyciechowski S, Garbarini J, Loomes KM, Krantz ID, Urban Z, Gelb BD, Goldmuntz E, Spinner NB.

Hum Mutat. 2010 May;31(5):594-601. doi: 10.1002/humu.21231.


Notch ligand delta-like1: X-ray crystal structure and binding affinity.

Kershaw NJ, Church NL, Griffin MD, Luo CS, Adams TE, Burgess AW.

Biochem J. 2015 May 15;468(1):159-66. doi: 10.1042/BJ20150010.


The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase.

Kim MY, Jung J, Mo JS, Ann EJ, Ahn JS, Yoon JH, Park HS.

Exp Cell Res. 2011 Oct 15;317(17):2438-46. doi: 10.1016/j.yexcr.2011.07.014. Epub 2011 Jul 29.


Expression of Notch1, Jagged1 and beta-catenin and their clinicopathological significance in hepatocellular carcinoma.

Wang M, Xue L, Cao Q, Lin Y, Ding Y, Yang P, Che L.

Neoplasma. 2009;56(6):533-41.


Notch1 and its ligand Jagged1 are present in remyelination in a T-cell- and antibody-mediated model of inflammatory demyelination.

Seifert T, Bauer J, Weissert R, Fazekas F, Storch MK.

Acta Neuropathol. 2007 Feb;113(2):195-203. Epub 2006 Nov 30.


Potential involvement of Notch1 signalling in the pathogenesis of primary cutaneous CD30-positive lymphoproliferative disorders.

Kamstrup MR, Ralfkiaer E, Skovgaard GL, Gniadecki R.

Br J Dermatol. 2008 Apr;158(4):747-53. doi: 10.1111/j.1365-2133.2007.08427.x. Epub 2008 Jan 30.


A role for notch signaling in human corneal epithelial cell differentiation and proliferation.

Ma A, Boulton M, Zhao B, Connon C, Cai J, Albon J.

Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3576-85.


The activated Notch1 signal pathway is associated with gastric cancer progression through cyclooxygenase-2.

Yeh TS, Wu CW, Hsu KW, Liao WJ, Yang MC, Li AF, Wang AM, Kuo ML, Chi CW.

Cancer Res. 2009 Jun 15;69(12):5039-48. doi: 10.1158/0008-5472.CAN-08-4021. Epub 2009 Jun 2.


Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination.

Zhang Y, Argaw AT, Gurfein BT, Zameer A, Snyder BJ, Ge C, Lu QR, Rowitch DH, Raine CS, Brosnan CF, John GR.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19162-7. doi: 10.1073/pnas.0902834106. Epub 2009 Oct 23.


[Expression and significance of Notch1, Jagged1 and VEGF in human non-small cell lung cancer].

Jiang X, Zhou JH, Deng ZH, Qu XH, Jiang HY, Liu Y.

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Dec;32(6):1031-6. Chinese.


Notch1 and Jagged1 expression by the developing pulmonary vasculature.

Taichman DB, Loomes KM, Schachtner SK, Guttentag S, Vu C, Williams P, Oakey RJ, Baldwin HS.

Dev Dyn. 2002 Oct;225(2):166-75.


Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development.

Felli MP, Maroder M, Mitsiadis TA, Campese AF, Bellavia D, Vacca A, Mann RS, Frati L, Lendahl U, Gulino A, Screpanti I.

Int Immunol. 1999 Jul;11(7):1017-25.


Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis.

Glittenberg M, Pitsouli C, Garvey C, Delidakis C, Bray S.

EMBO J. 2006 Oct 18;25(20):4697-706. Epub 2006 Sep 28.


Functional role of Notch signaling in the developing and postnatal heart.

Nemir M, Pedrazzini T.

J Mol Cell Cardiol. 2008 Oct;45(4):495-504. doi: 10.1016/j.yjmcc.2008.02.273. Epub 2008 Mar 10. Review.


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