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CHFR binds to and regulates MAD2 in the spindle checkpoint through its cysteine-rich domain.

Keller JA, Petty EM.

Biochem Biophys Res Commun. 2011 Jun 10;409(3):389-93. doi: 10.1016/j.bbrc.2011.04.143. Epub 2011 May 7.


Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.

Morrow CJ, Tighe A, Johnson VL, Scott MI, Ditchfield C, Taylor SS.

J Cell Sci. 2005 Aug 15;118(Pt 16):3639-52. Epub 2005 Jul 26.


Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.

Liu Q, Hirohashi Y, Du X, Greene MI, Wang Q.

Exp Mol Pathol. 2010 Apr;88(2):225-33. doi: 10.1016/j.yexmp.2009.12.004. Epub 2009 Dec 23.


The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint.

Osmundson EC, Ray D, Moore FE, Gao Q, Thomsen GH, Kiyokawa H.

J Cell Biol. 2008 Oct 20;183(2):267-77. doi: 10.1083/jcb.200801049. Epub 2008 Oct 13.


Enhanced genomic instabilities caused by deregulated microtubule dynamics and chromosome segregation: a perspective from genetic studies in mice.

Rao CV, Yamada HY, Yao Y, Dai W.

Carcinogenesis. 2009 Sep;30(9):1469-74. doi: 10.1093/carcin/bgp081. Epub 2009 Apr 16. Review.


A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ.

Nat Cell Biol. 2007 May;9(5):556-64. Epub 2007 Apr 8.


BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex.

Tipton AR, Wang K, Link L, Bellizzi JJ, Huang H, Yen T, Liu ST.

J Biol Chem. 2011 Jun 17;286(24):21173-9. doi: 10.1074/jbc.M111.238543. Epub 2011 Apr 27.


Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.

Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS.

J Cell Biol. 2003 Apr 28;161(2):267-80.


Expression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 cells.

Ma Y, Yuan X, Wyatt WR, Pomerening JR.

PLoS One. 2012;7(3):e33835. doi: 10.1371/journal.pone.0033835. Epub 2012 Mar 29.


Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.

Park I, Lee HO, Choi E, Lee YK, Kwon MS, Min J, Park PG, Lee S, Kong YY, Gong G, Lee H.

J Cell Biol. 2013 Jul 22;202(2):295-309. doi: 10.1083/jcb.201210099.


Re-evaluating the role of Tao1 in the spindle checkpoint.

Westhorpe FG, Diez MA, Gurden MD, Tighe A, Taylor SS.

Chromosoma. 2010 Aug;119(4):371-9. doi: 10.1007/s00412-010-0261-1. Epub 2010 Feb 17.


Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells.

Kabeche L, Compton DA.

Curr Biol. 2012 Apr 10;22(7):638-44. doi: 10.1016/j.cub.2012.02.030. Epub 2012 Mar 8.


p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells.

Sihn CR, Suh EJ, Lee KH, Kim TY, Kim SH.

Cancer Lett. 2003 Nov 25;201(2):203-10.


Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization.

Zhu M, Wang F, Yan F, Yao PY, Du J, Gao X, Wang X, Wu Q, Ward T, Li J, Kioko S, Hu R, Xie W, Ding X, Yao X.

J Biol Chem. 2008 Jul 4;283(27):18916-25. doi: 10.1074/jbc.M710591200. Epub 2008 May 6.


MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes.

Vogt E, Sanhaji M, Klein W, Seidel T, Wordeman L, Eichenlaub-Ritter U.

Mol Hum Reprod. 2010 Sep;16(9):665-84. doi: 10.1093/molehr/gaq025. Epub 2010 Apr 20.


Phospho-Bcl-xL(Ser62) influences spindle assembly and chromosome segregation during mitosis.

Wang J, Beauchemin M, Bertrand R.

Cell Cycle. 2014;13(8):1313-26. doi: 10.4161/cc.28293. Epub 2014 Mar 3.

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