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18591394,26099855,22893028,25779532,18644846,18559892,21472432,22246806,25418486,18492819,28951826,20349222,24189472,31814016,27330716,24633916,26212606,24129189,21159964,17464326,30562747,22653339,31260687,19109696,30707413,17395747,15297438,19629134,34637808,29199180,15677503,32304741,15921666,24293218,16601139,33242093,19305497,12446838,20159858,20080856,24451129,16205636,25544271,26271343,23948121,27383524,26135354,17268797,21863214,27793043,24896641,25012492,17823375,27211800,19722195,23354132,24623724,26157144,32506763,27682474,24884462,19919955,25647410,28688763,34488550,27157393,20596694,27059255,21490406,24121653,29499409,17652745,18174526,27044747,26090483,24008080,19171749,18508854,20686688,27484784,22189689,33664748,27555288,21135100,22270541,20206402,26797785,22815481,26472337,20130018,17906960,17716668,31189710,31309426,28300830,20920255,19033399,16604358,28063906,21981022,30045994,28391375,19193809,25183803,20424162,24349255,21103982,24475223,34244887,21091646,19720788,21193559,34298014,19524066,20020050,19875615,21995961,33770188,21697995,21186267,20554776,21605081,21541314,24874742,18544642,21525936,23624402,23850759,35924334,21356208,27605406,23995397,20554909,21245960,35654124,31585902,23791840,19383982,20829347,18794136,24096873,20421300,19114033,20798690,31604108,33870911,20959717,24638036,19609006,22470469,20693577,24625983,19934004,35270009,21029306,23994168,22107872,21145844,19855386,21983012,23092759,23934647,35398186,21911445,22773666,35182797,18263853,36383638,21940431,20811050,19336676,21280192,35565803,21512771,35610186,21113143,18460448,24936061,36014863,17941056,23339444,18305250,19018094,24453024,21147505,22354021,34474604,19008341,35533795,24366643,19875812,19752026,18568130,25915053,34408924,24958502,20700529,24081881,36401257,21503675,20479126,22436701,30796752,24900988,24142645,19910452,23615449,23678184,22739985,23441162,35568065,19951900,24668805,23209735,21799120,19933995,22228718,20924496,24442147,32747719,34979142,25279668,24519940,19734355,34830138,18450959,25314137,19470609,18426796,23148209,20430872,20022965,23123816,21901118,23801577,18716665,24644288,20956533,19502591,28717166,34378991,22215650,23554479,19583814,36982731,35936891,21135141,19004820,33715527,23423573,20732869,18776938,32210535,20122151,20305782,25010593,35538036,22111039,24642635,23836031,21113145,34813903,18550819,23470621,23645676,19732428,19756487,16006626,22347430,21294793,20659334,31025089,22362176,28238747,23812432,18412159,25159668,21966512,19444596,23022383,22699564,36724947,23281479,20876114,34919378,23209157,22006246,23897822,34547510,21829464,23976981,19336499,24287694,33302552,22628618,22705729,19447887,34058476,20668104,22179718,25295624,20856677,20668028,22511781,23417716,18641051,35791631,19424493,24950764,19277909,36262827,25204656,32472767,23486342,22442300,21088934,34588186,18439838,33460792,34086738,20958979,22933109,19724676,22660795,19583950,22563482,33628710,19359519,18597185,21078775,25068701,20549303,33124187,20660016,24786832,19727664,22237685,22350662,34756890,21567299,33123915,35720191,34610358,23613946,34841454,18651105,19106640,36792037,23239919,36977992,21494687,34998792,36079898,23852435,22399686,35788477,19259124,21592363,35339476,34794887,19190890,19061639,21757703,22419109,18470663,22359472,19834331,36521248,22008477,25004092,24648512,34471408,24587347,24284823,26822088,25324488,24963104,15094714,31730796,32639626,36468845,23860123,34436723,21839170,34676487,19609503,35982901,35044456,36538285,20878317,37005308,22007022,24647085,23907635,24831415,28911649,34374810,35207470,36436490,35483744,20427528,15708603,19182512,20410017,24379348,35442627,20032468,18095460,36362372,24834975,22695615,21977023,27378176,34571827,21853325,27882946,22340719,20926918,21183949,16680093,31105269,22396011,36210604,35283426,36370223,36152427,36761184,34586566,22511768,35987388,18493855,28821633,21944825,36799271,20631012,21458293,32366942,34828301,32659331,24167719,24915520,37146542,20086228,36063978,24438339,34932899,34744770,20732873,20159982,20463293,20044139,21270237,20448044,20063116,33980998,31100053,24251109,18479704,23213352,20383171,31130849,24371088,21402790,34462628,29305625,35453564,34938860,34498493,22474427,20585452,21552349,24843469,19744850,24454515,18559534,19136991,18728164,21454544,21382862,20414047,21274285,19109178,36230152,33823883,32060407,24943845,34607978,36523813,35443738,35413383,36170814,21168319,36557235,34858775,22345510,19145491,35289326,34294679,32673756,35629947,20850340,19720825,19154989,22315398,22699507,23544167,18056632,30825198,36361808,34799565,36065460,21094031,32359405,21464300,36869805,35220333,36346508,36552609,35992665,18534616,20018749,24918436,23617753,22526614,36614074,22792088,25171414,37113489,32510600,18629365,34402906,32231775,22442299,21943253,20972601,24327956,36993175,36171907,35802384,35263600,22096360,24357695,37072614,33355143,37131821,24891937,34286011,20339528[uid]

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Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

Akerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR. Akerfeldt MC, et al. Diabetes. 2008 Nov;57(11):3034-44. doi: 10.2337/db07-1802. Epub 2008 Jun 30. Diabetes. 2008. PMID: 18591394 Free PMC article.

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms.

Brozzi F, Nardelli TR, Lopes M, Millard I, Barthson J, Igoillo-Esteve M, Grieco FA, Villate O, Oliveira JM, Casimir M, Bugliani M, Engin F, Hotamisligil GS, Marchetti P, Eizirik DL. Brozzi F, et al. Diabetologia. 2015 Oct;58(10):2307-16. doi: 10.1007/s00125-015-3669-6. Epub 2015 Jun 23. Diabetologia. 2015. PMID: 26099855

Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets.

Chan JY, Biden TJ, Laybutt DR. Chan JY, et al. Diabetologia. 2012 Nov;55(11):2999-3009. doi: 10.1007/s00125-012-2657-3. Epub 2012 Jul 28. Diabetologia. 2012. PMID: 22893028

Involvement of iron depletion in palmitate-induced lipotoxicity of beta cells.

Jung IR, Choi SE, Jung JG, Lee SA, Han SJ, Kim HJ, Kim DJ, Lee KW, Kang Y. Jung IR, et al. Mol Cell Endocrinol. 2015 May 15;407:74-84. doi: 10.1016/j.mce.2015.03.007. Epub 2015 Mar 14. Mol Cell Endocrinol. 2015. PMID: 25779532

Diazoxide-induced beta-cell rest reduces endoplasmic reticulum stress in lipotoxic beta-cells.

Sargsyan E, Ortsäter H, Thorn K, Bergsten P. Sargsyan E, et al. J Endocrinol. 2008 Oct;199(1):41-50. doi: 10.1677/JOE-08-0251. Epub 2008 Jul 21. J Endocrinol. 2008. PMID: 18644846

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M. Cunha DA, et al. J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. doi: 10.1242/jcs.026062. Epub 2008 Jun 17. J Cell Sci. 2008. PMID: 18559892 Free PMC article.

Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells.

Chan JY, Cooney GJ, Biden TJ, Laybutt DR. Chan JY, et al. Diabetologia. 2011 Jul;54(7):1766-76. doi: 10.1007/s00125-011-2139-z. Epub 2011 Apr 7. Diabetologia. 2011. PMID: 21472432

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway.

Cao J, Dai DL, Yao L, Yu HH, Ning B, Zhang Q, Chen J, Cheng WH, Shen W, Yang ZX. Cao J, et al. Mol Cell Biochem. 2012 May;364(1-2):115-29. doi: 10.1007/s11010-011-1211-9. Epub 2012 Jan 15. Mol Cell Biochem. 2012. PMID: 22246806

Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection.

Sun X, Lin Y, Huang Q, Shi J, Qiu L, Kang M, Chen Y, Fang C, Ye T, Dong S. Sun X, et al. J Cell Mol Med. 2015 Mar;19(3):581-94. doi: 10.1111/jcmm.12409. Epub 2014 Nov 23. J Cell Mol Med. 2015. PMID: 25418486 Free PMC article.

Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids.

Diakogiannaki E, Welters HJ, Morgan NG. Diakogiannaki E, et al. J Endocrinol. 2008 Jun;197(3):553-63. doi: 10.1677/JOE-08-0041. J Endocrinol. 2008. PMID: 18492819

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