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Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2.

Pi J, Diwan BA, Sun Y, Liu J, Qu W, He Y, Styblo M, Waalkes MP.

Free Radic Biol Med. 2008 Sep 1;45(5):651-8. doi: 10.1016/j.freeradbiomed.2008.05.020.


Hypermethylation of the Keap1 gene inactivates its function, promotes Nrf2 nuclear accumulation, and is involved in arsenite-induced human keratinocyte transformation.

Wang D, Ma Y, Yang X, Xu X, Zhao Y, Zhu Z, Wang X, Deng H, Li C, Gao F, Tong J, Yamanaka K, An Y.

Free Radic Biol Med. 2015 Dec;89:209-19. doi: 10.1016/j.freeradbiomed.2015.07.153.


Aberrant cytokeratin expression during arsenic-induced acquired malignant phenotype in human HaCaT keratinocytes consistent with epidermal carcinogenesis.

Sun Y, Pi J, Wang X, Tokar EJ, Liu J, Waalkes MP.

Toxicology. 2009 Aug 3;262(2):162-70. doi: 10.1016/j.tox.2009.06.003.


Arsenic transformation predisposes human skin keratinocytes to UV-induced DNA damage yet enhances their survival apparently by diminishing oxidant response.

Sun Y, Kojima C, Chignell C, Mason R, Waalkes MP.

Toxicol Appl Pharmacol. 2011 Sep 15;255(3):242-50. doi: 10.1016/j.taap.2011.07.006.


Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells.

Yang X, Wang D, Ma Y, Xu X, Zhu Z, Wang X, Deng H, Li C, Chen M, Tong J, Yamanaka K, An Y.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):231-9. doi: 10.1016/j.taap.2015.09.020.


Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytes.

Zhao R, Hou Y, Zhang Q, Woods CG, Xue P, Fu J, Yarborough K, Guan D, Andersen ME, Pi J.

Environ Health Perspect. 2012 Apr;120(4):583-9. doi: 10.1289/ehp.1104580.


Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide.

Pi J, Qu W, Reece JM, Kumagai Y, Waalkes MP.

Exp Cell Res. 2003 Nov 1;290(2):234-45.


CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure.

Huang S, Guo S, Guo F, Yang Q, Xiao X, Murata M, Ohnishi S, Kawanishi S, Ma N.

Eur J Histochem. 2013 Jan 14;57(1):e1. doi: 10.4081/ejh.2013.e1.


Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic.

Sun Y, Tokar EJ, Waalkes MP.

Toxicol Sci. 2012 Jan;125(1):20-9. doi: 10.1093/toxsci/kfr282.


Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance.

He YY, Pi J, Huang JL, Diwan BA, Waalkes MP, Chignell CF.

Oncogene. 2006 Jun 22;25(26):3680-8.


[Dynamic changes of ROS, MDA and SOD during arsenic-induced neoplastic transformation in human keratinocytes].

Ma Y, Wang D, Xu X, Yang X, Wang X, Zhu Z, Zhao Y, Chen M, Xu F, Fu L, Zhu J, Gao F, An Y.

Wei Sheng Yan Jiu. 2015 May;44(3):456-61. Chinese.


A novel role of the NRF2 transcription factor in the regulation of arsenite-mediated keratin 16 gene expression in human keratinocytes.

Endo H, Sugioka Y, Nakagi Y, Saijo Y, Yoshida T.

Environ Health Perspect. 2008 Jul;116(7):873-9. doi: 10.1289/ehp.10696.


Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis.

Pi J, He Y, Bortner C, Huang J, Liu J, Zhou T, Qu W, North SL, Kasprzak KS, Diwan BA, Chignell CF, Waalkes MP.

Int J Cancer. 2005 Aug 10;116(1):20-6.


Antioncogenic and Oncogenic Properties of Nrf2 in Arsenic-induced Carcinogenesis.

Son YO, Pratheeshkumar P, Roy RV, Hitron JA, Wang L, Divya SP, Xu M, Luo J, Chen G, Zhang Z, Shi X.

J Biol Chem. 2015 Nov 6;290(45):27090-100. doi: 10.1074/jbc.M115.675371.


Curcumin protects human keratinocytes against inorganic arsenite-induced acute cytotoxicity through an NRF2-dependent mechanism.

Zhao R, Yang B, Wang L, Xue P, Deng B, Zhang G, Jiang S, Zhang M, Liu M, Pi J, Guan D.

Oxid Med Cell Longev. 2013;2013:412576. doi: 10.1155/2013/412576.


EMT and CSC-like properties mediated by the IKKβ/IκBα/RelA signal pathway via the transcriptional regulator, Snail, are involved in the arsenite-induced neoplastic transformation of human keratinocytes.

Jiang R, Li Y, Xu Y, Zhou Y, Pang Y, Shen L, Zhao Y, Zhang J, Zhou J, Wang X, Liu Q.

Arch Toxicol. 2013 Jun;87(6):991-1000. doi: 10.1007/s00204-012-0933-0.


Arsenic-specific stem cell selection during malignant transformation.

Tokar EJ, Qu W, Liu J, Liu W, Webber MM, Phang JM, Waalkes MP.

J Natl Cancer Inst. 2010 May 5;102(9):638-49. doi: 10.1093/jnci/djq093.


Opposed arsenite-mediated regulation of p53-survivin is involved in neoplastic transformation, DNA damage, or apoptosis in human keratinocytes.

Li Y, Jiang R, Zhao Y, Xu Y, Ling M, Pang Y, Shen L, Zhou Y, Zhang J, Zhou J, Wang X, Liu Q.

Toxicology. 2012 Oct 28;300(3):121-31. doi: 10.1016/j.tox.2012.06.004.


Dermato-protective properties of ergothioneine through induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated Human keratinocytes.

Hseu YC, Lo HW, Korivi M, Tsai YC, Tang MJ, Yang HL.

Free Radic Biol Med. 2015 Sep;86:102-17. doi: 10.1016/j.freeradbiomed.2015.05.026.


Critical role of cellular glutathione homeostasis for trivalent inorganic arsenite-induced oxidative damage in human bronchial epithelial cells.

Jiang X, Chen C, Liu Y, Zhang P, Zhang Z.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Aug;770:35-45. doi: 10.1016/j.mrgentox.2014.04.016.

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