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Items: 1 to 20 of 85

1.

Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule.

Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Grauer DC, Lehmann M, Meijler MM, Janda KD, Ulevitch RJ.

Science. 2008 Jul 11;321(5886):259-63. doi: 10.1126/science.1156499. Epub 2008 Jun 19.

2.

The bacterial quorum-sensing signal molecule N-3-oxo-dodecanoyl-L-homoserine lactone reciprocally modulates pro- and anti-inflammatory cytokines in activated macrophages.

Glucksam-Galnoy Y, Sananes R, Silberstein N, Krief P, Kravchenko VV, Meijler MM, Zor T.

J Immunol. 2013 Jul 1;191(1):337-44. doi: 10.4049/jimmunol.1300368. Epub 2013 May 29.

3.

Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses.

Valentine CD, Zhang H, Phuan PW, Nguyen J, Verkman AS, Haggie PM.

Cell Microbiol. 2014 Jan;16(1):1-14. doi: 10.1111/cmi.12176. Epub 2013 Aug 22.

5.

N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways.

Kravchenko VV, Kaufmann GF, Mathison JC, Scott DA, Katz AZ, Wood MR, Brogan AP, Lehmann M, Mee JM, Iwata K, Pan Q, Fearns C, Knaus UG, Meijler MM, Janda KD, Ulevitch RJ.

J Biol Chem. 2006 Sep 29;281(39):28822-30. Epub 2006 Aug 7.

6.

Pseudomonas aeruginosa N-3-oxo-dodecanoyl-homoserine Lactone Elicits Changes in Cell Volume, Morphology, and AQP9 Characteristics in Macrophages.

Holm A, Magnusson KE, Vikström E.

Front Cell Infect Microbiol. 2016 Mar 24;6:32. doi: 10.3389/fcimb.2016.00032. eCollection 2016.

7.

Mouse and human cell activation by N-dodecanoyl-DL-homoserine lactone, a Chromobacterium violaceum autoinducer.

Gomi K, Kikuchi T, Tokue Y, Fujimura S, Uehara A, Takada H, Watanabe A, Nukiwa T.

Infect Immun. 2006 Dec;74(12):7029-31. Epub 2006 Sep 18.

8.

A bacterial small molecule undermining immune response signaling.

Schmitz ML, de la Vega L.

Chembiochem. 2008 Nov 3;9(16):2575-7. doi: 10.1002/cbic.200800562. No abstract available.

PMID:
18823058
9.

Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development.

Garner AL, Yu J, Struss AK, Kaufmann GF, Kravchenko VV, Janda KD.

Chem Commun (Camb). 2013 Feb 21;49(15):1515-7. doi: 10.1039/c3cc38851d.

10.

Immunization with 3-oxododecanoyl-L-homoserine lactone-protein conjugate protects mice from lethal Pseudomonas aeruginosa lung infection.

Miyairi S, Tateda K, Fuse ET, Ueda C, Saito H, Takabatake T, Ishii Y, Horikawa M, Ishiguro M, Standiford TJ, Yamaguchi K.

J Med Microbiol. 2006 Oct;55(Pt 10):1381-7.

PMID:
17005787
11.

The quorum quenching antibody RS2-1G9 protects macrophages from the cytotoxic effects of the Pseudomonas aeruginosa quorum sensing signalling molecule N-3-oxo-dodecanoyl-homoserine lactone.

Kaufmann GF, Park J, Mee JM, Ulevitch RJ, Janda KD.

Mol Immunol. 2008 May;45(9):2710-4. doi: 10.1016/j.molimm.2008.01.010. Epub 2008 Mar 4.

12.

p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia.

Sadikot RT, Zeng H, Yull FE, Li B, Cheng DS, Kernodle DS, Jansen ED, Contag CH, Segal BH, Holland SM, Blackwell TS, Christman JW.

J Immunol. 2004 Feb 1;172(3):1801-8.

13.

Pseudomonas aeruginosa quorum-sensing molecule homoserine lactone modulates inflammatory signaling through PERK and eI-F2α.

Grabiner MA, Fu Z, Wu T, Barry KC, Schwarzer C, Machen TE.

J Immunol. 2014 Aug 1;193(3):1459-67. doi: 10.4049/jimmunol.1303437. Epub 2014 Jul 2.

14.

Modulation of mammalian cell processes by bacterial quorum sensing molecules.

Kravchenko VV, Ulevitch RJ, Kaufmann GF.

Methods Mol Biol. 2011;692:133-45. doi: 10.1007/978-1-60761-971-0_10.

PMID:
21031309
15.

The Pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells.

Mayer ML, Sheridan JA, Blohmke CJ, Turvey SE, Hancock RE.

PLoS One. 2011 Jan 31;6(1):e16246. doi: 10.1371/journal.pone.0016246.

16.

Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta.

Kim BH, Roh E, Lee HY, Lee IJ, Ahn B, Jung SH, Lee H, Han SB, Kim Y.

Mol Pharmacol. 2008 Apr;73(4):1309-18. doi: 10.1124/mol.107.041251. Epub 2008 Jan 17.

PMID:
18202307
17.
18.

The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity.

Telford G, Wheeler D, Williams P, Tomkins PT, Appleby P, Sewell H, Stewart GS, Bycroft BW, Pritchard DI.

Infect Immun. 1998 Jan;66(1):36-42.

19.

The inhibition of LPS-induced production of inflammatory cytokines by HSP70 involves inactivation of the NF-kappaB pathway but not the MAPK pathways.

Shi Y, Tu Z, Tang D, Zhang H, Liu M, Wang K, Calderwood SK, Xiao X.

Shock. 2006 Sep;26(3):277-84.

PMID:
16912653
20.

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