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The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).

Sczaniecka M, Feoktistova A, May KM, Chen JS, Blyth J, Gould KL, Hardwick KG.

J Biol Chem. 2008 Aug 22;283(34):23039-47. doi: 10.1074/jbc.M803594200. Epub 2008 Jun 13.


Structure of the mitotic checkpoint complex.

Chao WC, Kulkarni K, Zhang Z, Kong EH, Barford D.

Nature. 2012 Mar 21;484(7393):208-13. doi: 10.1038/nature10896.


Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.

Zich J, Sochaj AM, Syred HM, Milne L, Cook AG, Ohkura H, Rappsilber J, Hardwick KG.

Curr Biol. 2012 Feb 21;22(4):296-301. doi: 10.1016/j.cub.2011.12.049. Epub 2012 Jan 25.


Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.

Zich J, May K, Paraskevopoulos K, Sen O, Syred HM, van der Sar S, Patel H, Moresco JJ, Sarkeshik A, Yates JR 3rd, Rappsilber J, Hardwick KG.

PLoS Genet. 2016 Feb 16;12(2):e1005834. doi: 10.1371/journal.pgen.1005834. eCollection 2016 Feb. Erratum in: PLoS Genet. 2016 Apr;12(4):e1006009.


BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner.

Lara-Gonzalez P, Scott MI, Diez M, Sen O, Taylor SS.

J Cell Sci. 2011 Dec 15;124(Pt 24):4332-45. doi: 10.1242/jcs.094763. Epub 2011 Dec 22.


The spindle checkpoint: how do cells delay anaphase onset?

Sczaniecka MM, Hardwick KG.

SEB Exp Biol Ser. 2008;59:243-56. Review.


Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.

Tian W, Li B, Warrington R, Tomchick DR, Yu H, Luo X.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18419-24. doi: 10.1073/pnas.1213438109. Epub 2012 Oct 22.


Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding.

Kulukian A, Han JS, Cleveland DW.

Dev Cell. 2009 Jan;16(1):105-17. doi: 10.1016/j.devcel.2008.11.005.


A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism.

Vanoosthuyse V, Hardwick KG.

Curr Biol. 2009 Jul 28;19(14):1176-81. doi: 10.1016/j.cub.2009.05.060. Epub 2009 Jul 9.


Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.

Morrow CJ, Tighe A, Johnson VL, Scott MI, Ditchfield C, Taylor SS.

J Cell Sci. 2005 Aug 15;118(Pt 16):3639-52. Epub 2005 Jul 26.


The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.

Nilsson J, Yekezare M, Minshull J, Pines J.

Nat Cell Biol. 2008 Dec;10(12):1411-20. doi: 10.1038/ncb1799. Epub 2008 Nov 9.


An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast.

Horikoshi Y, Habu T, Matsumoto T.

Cell Cycle. 2013 Mar 15;12(6):961-71. doi: 10.4161/cc.23946. Epub 2013 Feb 26.


Spindle checkpoint protein dynamics at kinetochores in living cells.

Howell BJ, Moree B, Farrar EM, Stewart S, Fang G, Salmon ED.

Curr Biol. 2004 Jun 8;14(11):953-64.


C-terminal region of Mad2 plays an important role during mitotic spindle checkpoint in fission yeast Schizosaccharomyces pombe.

Singh GK, Karade SS, Ranjan R, Ahamad N, Ahmed S.

Mol Biol Rep. 2017 Feb;44(1):89-96. doi: 10.1007/s11033-016-4083-y. Epub 2016 Sep 23.


Dual inhibition of Cdc20 by the spindle checkpoint.

Chen RH.

J Biomed Sci. 2007 Jul;14(4):475-9. Epub 2007 Mar 17. Review.


BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex.

Tipton AR, Wang K, Link L, Bellizzi JJ, Huang H, Yen T, Liu ST.

J Biol Chem. 2011 Jun 17;286(24):21173-9. doi: 10.1074/jbc.M111.238543. Epub 2011 Apr 27.


The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.

Foster SA, Morgan DO.

Mol Cell. 2012 Sep 28;47(6):921-32. doi: 10.1016/j.molcel.2012.07.031. Epub 2012 Aug 30.

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