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18544579,19039823,18726925,16388509,19526452,12230441,17269128,18432600,15736186,16601335,16952214,16245371,19248005,23289277,18264956,27549925,15507982,16049986,24356462,18461550,23744609,25307357,17077242,15906423,7526305,19031473,18176905,10341399,10590430,32621353,15057947,11494294,16752230,19189527,17342500,15507981,19133038,19222026,18512854,12124697,20052660,19288457,20332643,12673635,17346554,16240322,20595943,16231401,12420837,17992705,18186136,24444556,15802030,17766613,20658511,22611005,31710734,12378569,17554803,19106261,17286311,21793085,17999381,19294632,23080546,16098850,7538782,19085755,17867331,21709403,17590888,10820411,21952001,17342495,19173346,17315110,19362411,17437322,16946227,30950006,17960785,15459938,12628267,22572044,21576269,14558032,18720036,19408250,18757658,18236423,19338027,17075793,22614037,20197657,15736185,21570171,12842057,19288535,14534333,30919147,18729035,22025131,11474996,10589055,22536640,33447994,10416969,21229566,17003556,21667432,20503223,21210478,8863700,19025178,23744626,21701138,15458882,16752435,16458636,20088400,21988784,18302310,17509577,12210583,23881389,25315809,16104667,23494847,26498918,12627428,20301994,16949423,22807155,19266536,21305437,8903913,10951481,14552058,24501862,7947527,24503519,26970114,16813749,22274905,19115229,11288115,15229844,25297598,18677711,12661334,21611995,20101668,12012633,17470580,19246467,16634118,15295343,15228997,10861716,22570267,23092801,25302655,23107079,17346522,26251461,15042005,15662693,19842139,2389806,17803717,17009346,15970804,8058241,21062401,15300745,16389021,25315699,16634123,28099747,20183867,22482987,16810709,23354915,32495931,15548144,17590886,18318000,12575025,25708180,16537243,23178003,20301870,16697944,25057869,32266955,20799245,22508575,16435317,20466286,20440731,10694680,17171632,28553771,17904965,24192489,21422752,25297464,19097032,22418959,33128403,17333228,17249384,18098339,18303498,20301202,22286035,12378574,26538356,11559905,11425838,16596511,17828795,25251385,16921789,15229849,9793972,7528054,29057435,16710884,16519620,24411037,16225579,30353581,16582126,11914564,18383462,18000943,18946222,18257654,20798483,15262353,21210476,16626615,19517696,11494288,23761419,19716535,19090499,32977750,8652486,24731729,17131919,17154335,8863698,17426792,27958633,22886467,19541861,11518881,15696876,17501960,25864278,17042034,17601890,11920896,18661488,27915499,18816495,18186146,19816033,19006100,22377654,19495781,25543334,24381414,16491510,14755412,11981911,15966039,19031359,11028580,16533653,16098861,27569022,9476321,30519751,16644613,15838748,7530490,17220033,18784463,19856826,19416569,12522563,10482866,10985971,25118506,9244963,31165549,25754604,14618660,20708518,23138752,18771987,25417487,19009556,20925041,18925580,34750768,25222592,30049248,17018983,30977206,19574080,19564524,16569299,19248042,33207975,27597552,20721873,15614873,19178062,35294217,18236431,35339997,15880648,16231301,16519623,8568468,28397325,36468756,33838069,24055486,19288397,18382996,19003979,22464073,19062506,18669714,21895611,22742782,8988688,24195065,19097030,26785129,11898965,26266002,22309076,26709085,30199859,17361088,16845680,17451100,9021825,18704469,16959807,19488973,16205601,15712327,16485319,25803072,19142904,15662668,30122574,23494956,17584747,10030400,12116311,19650060,29057433,18253026,20661890,15503284,35603424,17652924,8735748,14558033,15000919,18626869,15130310,8446569,12813756,32811232,21692089,18405480,18925623,20925129,15849793,31122094,19065360,17118742,18609362,31706055,24832209,16374897,31429096,15346821,15503716,7837124,10566163,24247435,18164000,12423486,21146323,33034897,33068386,9259939,16231400,18208717,15210050,15665026,16700399,27812158,18295168,21210479,24513694,35727579,2533599,24375422,7474053,16794987,10377014,29080223,19911411,20708516,7971755,34159403,17934295,16461028,27008689,20457798,17140176,30581343,25239075,9527952,21294134,18440001,18307174,17574347,7650329,9497154,15300743,30025867,8532618,8590187,22913322,18455162,35279726,20384468,7778044,18409283,17099926,33618603,17584770,21867405,25031576,15503288,17656178,17416916,18037327,12521883,19921649,16193464,17234369,10072643,16433695,25914417,16906599,32659771,10364671,17437325,9238717,17092638,17533625,12916678,14511427,18421024,17018982,20082470,22495937,10611254,12017243,15737127,33603798,8710811,27689162,36048565,28613385,15386463,7198887,24327427,17437234,15214948,26237381,7889657,33818248,7686606,16168201,17694977,22391621,28171857,18425474,17074451,2525109,16553936,27256660,14767916,16211953,18191801,18348276,20661054,17214048,34434280,17661383,16308891,18504375,29956348,21520314,9071083,15162517,15512336,28423979,2871243,10521833,11241476,16302283,17626711,2222635,18467377,2977936,18438966,23315481,15906412,17656265,1398642,9429849,6037474,26097020,2672026,17072899,15906415,28804563,3752082,33094011,9540958,17705236,17706630,16034830,30258244,25258455,18534928,18378745,15791680,28608970,15198723,26237481,18383001,18229657,21885064,18391338,179946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Screening for trisomies 21, 18 and 13 by maternal age, fetal nuchal translucency, fetal heart rate, free beta-hCG and pregnancy-associated plasma protein-A.

Kagan KO, Wright D, Valencia C, Maiz N, Nicolaides KH. Kagan KO, et al. Hum Reprod. 2008 Sep;23(9):1968-75. doi: 10.1093/humrep/den224. Epub 2008 Jun 10. Hum Reprod. 2008. PMID: 18544579

Screening for triploidy by the risk algorithms for trisomies 21, 18 and 13 at 11 weeks to 13 weeks and 6 days of gestation.

Kagan KO, Anderson JM, Anwandter G, Neksasova K, Nicolaides KH. Kagan KO, et al. Prenat Diagn. 2008 Dec;28(13):1209-13. doi: 10.1002/pd.2149. Prenat Diagn. 2008. PMID: 19039823

Screening for trisomy 18 by maternal age, fetal nuchal translucency, free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A.

Kagan KO, Wright D, Maiz N, Pandeva I, Nicolaides KH. Kagan KO, et al. Ultrasound Obstet Gynecol. 2008 Sep;32(4):488-92. doi: 10.1002/uog.6123. Ultrasound Obstet Gynecol. 2008. PMID: 18726925 Free article.

Screening for trisomy 21 by fetal tricuspid regurgitation, nuchal translucency and maternal serum free beta-hCG and PAPP-A at 11 + 0 to 13 + 6 weeks.

Falcon O, Auer M, Gerovassili A, Spencer K, Nicolaides KH. Falcon O, et al. Ultrasound Obstet Gynecol. 2006 Feb;27(2):151-5. doi: 10.1002/uog.2699. Ultrasound Obstet Gynecol. 2006. PMID: 16388509 Free article.

Prospective validation of first-trimester combined screening for trisomy 21.

Kagan KO, Etchegaray A, Zhou Y, Wright D, Nicolaides KH. Kagan KO, et al. Ultrasound Obstet Gynecol. 2009 Jul;34(1):14-8. doi: 10.1002/uog.6412. Ultrasound Obstet Gynecol. 2009. PMID: 19526452 Free article.

One-stop clinic for assessment of risk for trisomy 21 at 11-14 weeks: a prospective study of 15 030 pregnancies.

Bindra R, Heath V, Liao A, Spencer K, Nicolaides KH. Bindra R, et al. Ultrasound Obstet Gynecol. 2002 Sep;20(3):219-25. doi: 10.1046/j.1469-0705.2002.00808.x. Ultrasound Obstet Gynecol. 2002. PMID: 12230441 Free article.

Maternal serum free-beta-chorionic gonadotrophin, pregnancy-associated plasma protein-A and fetal nuchal translucency thickness at 10-13(+6) weeks in relation to co-variables in pregnant Saudi women.

Ardawi MS, Nasrat HA, Rouzi AA, Qari MH, Al-Qahtani MH, Abuzenadah AM. Ardawi MS, et al. Prenat Diagn. 2007 Apr;27(4):303-11. doi: 10.1002/pd.1661. Prenat Diagn. 2007. PMID: 17269128

First-trimester screening for trisomy 21 by free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A: impact of maternal and pregnancy characteristics.

Kagan KO, Wright D, Spencer K, Molina FS, Nicolaides KH. Kagan KO, et al. Ultrasound Obstet Gynecol. 2008 May;31(5):493-502. doi: 10.1002/uog.5332. Ultrasound Obstet Gynecol. 2008. PMID: 18432600 Free article.

Multicenter study of first-trimester screening for trisomy 21 in 75 821 pregnancies: results and estimation of the potential impact of individual risk-orientated two-stage first-trimester screening.

Nicolaides KH, Spencer K, Avgidou K, Faiola S, Falcon O. Nicolaides KH, et al. Ultrasound Obstet Gynecol. 2005 Mar;25(3):221-6. doi: 10.1002/uog.1860. Ultrasound Obstet Gynecol. 2005. PMID: 15736186 Free article.

Screening for trisomy 21 with maternal age, fetal nuchal translucency and maternal serum biochemistry at 11-14 weeks: a regional experience from Germany.

Soergel P, Pruggmayer M, Schwerdtfeger R, Muhlhaus K, Scharf A. Soergel P, et al. Fetal Diagn Ther. 2006;21(3):264-8. doi: 10.1159/000091353. Fetal Diagn Ther. 2006. PMID: 16601335

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