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PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.

Wigfield SM, Winter SC, Giatromanolaki A, Taylor J, Koukourakis ML, Harris AL.

Br J Cancer. 2008 Jun 17;98(12):1975-84. doi: 10.1038/sj.bjc.6604356. Epub 2008 Jun 10.


Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target.

Hur H, Xuan Y, Kim YB, Lee G, Shim W, Yun J, Ham IH, Han SU.

Int J Oncol. 2013 Jan;42(1):44-54. doi: 10.3892/ijo.2012.1687. Epub 2012 Nov 6.


Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.

Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM.

Clin Cancer Res. 2006 Feb 15;12(4):1080-7.


Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.

Beasley NJ, Leek R, Alam M, Turley H, Cox GJ, Gatter K, Millard P, Fuggle S, Harris AL.

Cancer Res. 2002 May 1;62(9):2493-7.


TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization.

Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha PK, Califano JA.

Clin Cancer Res. 2010 Feb 1;16(3):857-66. doi: 10.1158/1078-0432.CCR-09-2604. Epub 2010 Jan 26.


Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells.

McFate T, Mohyeldin A, Lu H, Thakar J, Henriques J, Halim ND, Wu H, Schell MJ, Tsang TM, Teahan O, Zhou S, Califano JA, Jeoung NH, Harris RA, Verma A.

J Biol Chem. 2008 Aug 15;283(33):22700-8. doi: 10.1074/jbc.M801765200. Epub 2008 Jun 9.


Relation of erythropoietin and erythropoietin receptor expression to hypoxia and anemia in head and neck squamous cell carcinoma.

Winter SC, Shah KA, Campo L, Turley H, Leek R, Corbridge RJ, Cox GJ, Harris AL.

Clin Cancer Res. 2005 Nov 1;11(21):7614-20.


The relation between hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression with anemia and outcome in surgically treated head and neck cancer.

Winter SC, Shah KA, Han C, Campo L, Turley H, Leek R, Corbridge RJ, Cox GJ, Harris AL.

Cancer. 2006 Aug 15;107(4):757-66.


Hypoxia-inducible factor 1alpha and antiangiogenic activity of farnesyltransferase inhibitor SCH66336 in human aerodigestive tract cancer.

Han JY, Oh SH, Morgillo F, Myers JN, Kim E, Hong WK, Lee HY.

J Natl Cancer Inst. 2005 Sep 7;97(17):1272-86. Erratum in: J Natl Cancer Inst. 2007 Aug 1;99(15):1211.


Knockdown of β-catenin controls both apoptotic and autophagic cell death through LKB1/AMPK signaling in head and neck squamous cell carcinoma cell lines.

Chang HW, Lee YS, Nam HY, Han MW, Kim HJ, Moon SY, Jeon H, Park JJ, Carey TE, Chang SE, Kim SW, Kim SY.

Cell Signal. 2013 Apr;25(4):839-47. doi: 10.1016/j.cellsig.2012.12.020. Epub 2012 Dec 30.


MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma.

Zhang L, Sun ZJ, Bian Y, Kulkarni AB.

Cancer Lett. 2013 May 1;331(2):230-8. doi: 10.1016/j.canlet.2013.01.003. Epub 2013 Jan 20.


The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia.

Schaaf MB, Cojocari D, Keulers TG, Jutten B, Starmans MH, de Jong MC, Begg AC, Savelkouls KG, Bussink J, Vooijs M, Wouters BG, Rouschop KM.

Radiother Oncol. 2013 Sep;108(3):529-34. doi: 10.1016/j.radonc.2013.06.015. Epub 2013 Jul 9.


Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas.

Le QT, Kong C, Lavori PW, O'byrne K, Erler JT, Huang X, Chen Y, Cao H, Tibshirani R, Denko N, Giaccia AJ, Koong AC.

Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):167-75.


Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures.

Gross J, Fuchs J, Machulik A, Jahnke V, Kietzmann T, Bockmühl U.

Int J Oncol. 2005 Sep;27(3):807-14.


Clinical implications of hypoxia biomarker expression in head and neck squamous cell carcinoma: a systematic review.

Swartz JE, Pothen AJ, Stegeman I, Willems SM, Grolman W.

Cancer Med. 2015 Jul;4(7):1101-16. doi: 10.1002/cam4.460. Epub 2015 Apr 27. Review.


The paracrine effect of cancer-associated fibroblast-induced interleukin-33 regulates the invasiveness of head and neck squamous cell carcinoma.

Chen SF, Nieh S, Jao SW, Wu MZ, Liu CL, Chang YC, Lin YS.

J Pathol. 2013 Oct;231(2):180-9. doi: 10.1002/path.4226. Epub 2013 Aug 12.


HIF-α/MIF and NF-κB/IL-6 axes contribute to the recruitment of CD11b+Gr-1+ myeloid cells in hypoxic microenvironment of HNSCC.

Zhu G, Tang Y, Geng N, Zheng M, Jiang J, Li L, Li K, Lei Z, Chen W, Fan Y, Ma X, Li L, Wang X, Liang X.

Neoplasia. 2014 Feb;16(2):168-79. doi: 10.1593/neo.132034.


Induction of plasminogen activator inhibitor type-1 (PAI-1) by hypoxia and irradiation in human head and neck carcinoma cell lines.

Schilling D, Bayer C, Geurts-Moespot A, Sweep FC, Pruschy M, Mengele K, Sprague LD, Molls M.

BMC Cancer. 2007 Jul 30;7:143.

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