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Items: 1 to 20 of 92

1.

Selective influence on contextual memory: physiochemical properties associated with selectivity of benzodiazepine ligands at GABAA receptors containing the alpha5 subunit.

Harris D, Clayton T, Cook J, Sahbaie P, Halliwell RF, Furtmüller R, Huck S, Sieghart W, DeLorey TM.

J Med Chem. 2008 Jul 10;51(13):3788-803. doi: 10.1021/jm701433b. Epub 2008 Jun 7.

PMID:
18537233
2.
3.

PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats.

Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM.

Brain Res. 2008 May 7;1208:150-9. doi: 10.1016/j.brainres.2008.02.020. Epub 2008 Feb 19.

5.

Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.

Casula MA, Bromidge FA, Pillai GV, Wingrove PB, Martin K, Maubach K, Seabrook GR, Whiting PJ, Hadingham KL.

J Neurochem. 2001 Apr;77(2):445-51.

6.

Influence of benzodiazepine binding site ligands on fear-conditioned contextual memory.

DeLorey TM, Lin RC, McBrady B, He X, Cook JM, Lameh J, Loew GH.

Eur J Pharmacol. 2001 Aug 24;426(1-2):45-54.

PMID:
11525770
7.

Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?

Savić MM, Majumder S, Huang S, Edwankar RV, Furtmüller R, Joksimović S, Clayton T Sr, Ramerstorfer J, Milinković MM, Roth BL, Sieghart W, Cook JM.

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):376-86. doi: 10.1016/j.pnpbp.2010.01.004. Epub 2010 Jan 13.

8.

A closer look at the high affinity benzodiazepine binding site on GABAA receptors.

Sigel E, Lüscher BP.

Curr Top Med Chem. 2011;11(2):241-6. Review.

PMID:
21189125
9.

Loop-F of the α-subunit determines the pharmacologic profile of novel competitive inhibitors of GABAA receptors.

Mihalik B, Pálvölgyi A, Bogár F, Megyeri K, Ling I, Barkóczy J, Bartha F, Martinek TA, Gacsályi I, Antoni FA.

Eur J Pharmacol. 2017 Mar 5;798:129-136. doi: 10.1016/j.ejphar.2017.01.033. Epub 2017 Jan 31.

PMID:
28153485
10.

3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors.

Huang X, Liu T, Gu J, Luo X, Ji R, Cao Y, Xue H, Wong JT, Wong BL, Pei G, Jiang H, Chen K.

J Med Chem. 2001 Jun 7;44(12):1883-91.

PMID:
11384234
11.

Molecular determinants of recognition and activation at the cerebellar benzodiazepine receptor site.

Schove LT, Perez JJ, Loew GH.

Bioorg Med Chem. 1994 Oct;2(10):1029-49.

PMID:
7773620
12.

Benzodiazepine-induced hyperphagia: development and assessment of a 3D pharmacophore by computational methods.

Filizola M, Harris DL, Loew GH.

J Biomol Struct Dyn. 2000 Apr;17(5):769-78.

PMID:
10798522
13.

New insight into the central benzodiazepine receptor-ligand interactions: design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and related compounds.

Anzini M, Valenti S, Braile C, Cappelli A, Vomero S, Alcaro S, Ortuso F, Marinelli L, Limongelli V, Novellino E, Betti L, Giannaccini G, Lucacchini A, Daniele S, Martini C, Ghelardini C, Di Cesare Mannelli L, Giorgi G, Mascia MP, Biggio G.

J Med Chem. 2011 Aug 25;54(16):5694-711. doi: 10.1021/jm2001597. Epub 2011 Jul 27.

PMID:
21751815
14.

Determinants of recognition of ligands binding to benzodiazepine receptor/GABA(A) receptors initiating sedation.

Harris DL, DeLorey TM, He X, Cook JM, Loew GH.

Eur J Pharmacol. 2000 Aug 11;401(3):271-87.

PMID:
10936485
15.

Mapping of the benzodiazepine recognition site on GABA(A) receptors.

Sigel E.

Curr Top Med Chem. 2002 Aug;2(8):833-9. Review.

PMID:
12171574
16.

Structural determinants for antagonist pharmacology that distinguish the rho1 GABAC receptor from GABAA receptors.

Zhang J, Xue F, Chang Y.

Mol Pharmacol. 2008 Oct;74(4):941-51. doi: 10.1124/mol.108.048710. Epub 2008 Jul 3.

19.

Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site.

Jansen M, Rabe H, Strehle A, Dieler S, Debus F, Dannhardt G, Akabas MH, Lüddens H.

J Med Chem. 2008 Aug 14;51(15):4430-48. doi: 10.1021/jm701562x. Epub 2008 Jul 24.

20.

Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors.

Petroski RE, Pomeroy JE, Das R, Bowman H, Yang W, Chen AP, Foster AC.

J Pharmacol Exp Ther. 2006 Apr;317(1):369-77. Epub 2006 Jan 6.

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