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Items: 1 to 20 of 104

1.

Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog.

Buglino JA, Resh MD.

J Biol Chem. 2008 Aug 8;283(32):22076-88. doi: 10.1074/jbc.M803901200. Epub 2008 Jun 4.

2.

Identification of N-terminal residues of Sonic Hedgehog important for palmitoylation by Hedgehog acyltransferase.

Hardy RY, Resh MD.

J Biol Chem. 2012 Dec 14;287(51):42881-9. doi: 10.1074/jbc.M112.426833. Epub 2012 Oct 30.

3.

Membrane topology of hedgehog acyltransferase.

Matevossian A, Resh MD.

J Biol Chem. 2015 Jan 23;290(4):2235-43. doi: 10.1074/jbc.M114.625764. Epub 2014 Dec 8.

4.

Palmitoylation of Hedgehog proteins.

Buglino JA, Resh MD.

Vitam Horm. 2012;88:229-52. doi: 10.1016/B978-0-12-394622-5.00010-9. Review.

5.
6.

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling.

Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD.

Nat Chem Biol. 2013 Apr;9(4):247-9. doi: 10.1038/nchembio.1184. Epub 2013 Feb 17.

7.

Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.

Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW.

Anal Biochem. 2015 Dec 1;490:66-72. doi: 10.1016/j.ab.2015.08.025. Epub 2015 Sep 1.

8.

Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

Konitsiotis AD, Chang SC, Jovanović B, Ciepla P, Masumoto N, Palmer CP, Tate EW, Couchman JR, Magee AI.

PLoS One. 2014 Mar 7;9(3):e89899. doi: 10.1371/journal.pone.0089899. eCollection 2014.

9.

Palmitoylation of proteins in cancer.

Resh MD.

Biochem Soc Trans. 2017 Apr 15;45(2):409-416. doi: 10.1042/BST20160233. Review.

PMID:
28408481
10.

Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling.

Callier P, Calvel P, Matevossian A, Makrythanasis P, Bernard P, Kurosaka H, Vannier A, Thauvin-Robinet C, Borel C, Mazaud-Guittot S, Rolland A, Desdoits-Lethimonier C, Guipponi M, Zimmermann C, Stévant I, Kuhne F, Conne B, Santoni F, Lambert S, Huet F, Mugneret F, Jaruzelska J, Faivre L, Wilhelm D, Jégou B, Trainor PA, Resh MD, Antonarakis SE, Nef S.

PLoS Genet. 2014 May 1;10(5):e1004340. doi: 10.1371/journal.pgen.1004340. eCollection 2014 May.

11.

Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.

Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW.

ACS Chem Biol. 2016 Dec 16;11(12):3256-3262. Epub 2016 Oct 25.

12.

Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein.

Konitsiotis AD, Jovanović B, Ciepla P, Spitaler M, Lanyon-Hogg T, Tate EW, Magee AI.

J Biol Chem. 2015 Feb 6;290(6):3293-307. doi: 10.1074/jbc.M114.614578. Epub 2014 Dec 12.

13.
14.

Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects.

Dennis JF, Kurosaka H, Iulianella A, Pace J, Thomas N, Beckham S, Williams T, Trainor PA.

PLoS Genet. 2012;8(10):e1002927. doi: 10.1371/journal.pgen.1002927. Epub 2012 Oct 4.

15.

Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.

Huang K, Sanders S, Singaraja R, Orban P, Cijsouw T, Arstikaitis P, Yanai A, Hayden MR, El-Husseini A.

FASEB J. 2009 Aug;23(8):2605-15. doi: 10.1096/fj.08-127399. Epub 2009 Mar 19.

16.

Palmitoylation of ATP-binding cassette transporter A1 is essential for its trafficking and function.

Singaraja RR, Kang MH, Vaid K, Sanders SS, Vilas GL, Arstikaitis P, Coutinho J, Drisdel RC, El-Husseini Ael D, Green WN, Berthiaume L, Hayden MR.

Circ Res. 2009 Jul 17;105(2):138-47. doi: 10.1161/CIRCRESAHA.108.193011. Epub 2009 Jun 25.

17.

Microfluidic Mobility Shift Assay for Real-Time Analysis of Peptide N-Palmitoylation.

Lanyon-Hogg T, Patel NV, Ritzefeld M, Boxall KJ, Burke R, Blagg J, Magee AI, Tate EW.

SLAS Discov. 2017 Apr;22(4):418-424. doi: 10.1177/2472555216689529. Epub 2017 Jan 31.

PMID:
28296537
18.

Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma.

Petrova E, Matevossian A, Resh MD.

Oncogene. 2015 Jan 8;34(2):263-8. doi: 10.1038/onc.2013.575. Epub 2014 Jan 27.

19.

Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes.

Gao X, Arenas-Ramirez N, Scales SJ, Hannoush RN.

FEBS Lett. 2011 Aug 4;585(15):2501-6. doi: 10.1016/j.febslet.2011.06.033. Epub 2011 Jul 2.

20.

Palmitoyl acyltransferases, their substrates, and novel assays to connect them (Review).

Planey SL, Zacharias DA.

Mol Membr Biol. 2009 Jan;26(1):14-31. doi: 10.1080/09687680802646703. Review.

PMID:
19191172

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