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Items: 1 to 20 of 82

1.

Central delivery of Dicer-substrate siRNA: a direct application for pain research.

Doré-Savard L, Roussy G, Dansereau MA, Collingwood MA, Lennox KA, Rose SD, Beaudet N, Behlke MA, Sarret P.

Mol Ther. 2008 Jul;16(7):1331-9. doi: 10.1038/mt.2008.98. Epub 2008 Jun 3.

2.

Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development.

Bégin-Lavallée V, Midavaine É, Dansereau MA, Tétreault P, Longpré JM, Jacobi AM, Rose SD, Behlke MA, Beaudet N, Sarret P.

Mol Pain. 2016 Jun 15;12. pii: 1744806916653969. doi: 10.1177/1744806916653969. Print 2016.

3.

Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity.

Roussy G, Dansereau MA, Baudisson S, Ezzoubaa F, Belleville K, Beaudet N, Martinez J, Richelson E, Sarret P.

Mol Pain. 2009 Jul 6;5:38. doi: 10.1186/1744-8069-5-38.

4.

Potent spinal analgesia elicited through stimulation of NTS2 neurotensin receptors.

Sarret P, Esdaile MJ, Perron A, Martinez J, Stroh T, Beaudet A.

J Neurosci. 2005 Sep 7;25(36):8188-96.

5.

An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons.

Luo MC, Zhang DQ, Ma SW, Huang YY, Shuster SJ, Porreca F, Lai J.

Mol Pain. 2005 Sep 28;1:29.

6.

Spinal NTS2 receptor activation reverses signs of neuropathic pain.

Tétreault P, Beaudet N, Perron A, Belleville K, René A, Cavelier F, Martinez J, Stroh T, Jacobi AM, Rose SD, Behlke MA, Sarret P.

FASEB J. 2013 Sep;27(9):3741-52. doi: 10.1096/fj.12-225540. Epub 2013 Jun 11.

PMID:
23756650
7.

Intrathecal administration of NTS1 agonists reverses nociceptive behaviors in a rat model of neuropathic pain.

Guillemette A, Dansereau MA, Beaudet N, Richelson E, Sarret P.

Eur J Pain. 2012 Apr;16(4):473-84. doi: 10.1016/j.ejpain.2011.07.008.

PMID:
22396077
8.

Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model.

Roussy G, Dansereau MA, Doré-Savard L, Belleville K, Beaudet N, Richelson E, Sarret P.

J Neurochem. 2008 May;105(4):1100-14. doi: 10.1111/j.1471-4159.2007.05205.x. Epub 2007 Dec 25.

9.

Dicer-substrate siRNA inhibits tumor necrosis factor alpha secretion in Kupffer cells in vitro: in vivo targeting of Kupffer cells by siRNA-liposomes.

Pichu S, Krishnamoorthy S, Zhang B, Jing Y, Shishkov A, Ponnappa BC.

Pharmacol Res. 2012 Jan;65(1):48-55. doi: 10.1016/j.phrs.2011.09.001. Epub 2011 Sep 10.

10.

Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.

Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP.

J Med Chem. 2014 Sep 11;57(17):7472-7. doi: 10.1021/jm500857r. Epub 2014 Aug 26.

11.

Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.

Thomas JB, Giddings AM, Wiethe RW, Olepu S, Warner KR, Sarret P, Gendron L, Longpre JM, Zhang Y, Runyon SP, Gilmour BP.

J Med Chem. 2014 Jun 26;57(12):5318-32. doi: 10.1021/jm5003843. Epub 2014 Jun 5.

12.

RNA interference in vitro and in vivo using DsiRNA targeting the nucleocapsid N mRNA of human metapneumovirus.

Darniot M, Schildgen V, Schildgen O, Sproat B, Kleines M, Ditt V, Pitoiset C, Pothier P, Manoha C.

Antiviral Res. 2012 Mar;93(3):364-73. doi: 10.1016/j.antiviral.2012.01.004. Epub 2012 Jan 20.

PMID:
22285728
13.

Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo.

Foster DJ, Barros S, Duncan R, Shaikh S, Cantley W, Dell A, Bulgakova E, O'Shea J, Taneja N, Kuchimanchi S, Sherrill CB, Akinc A, Hinkle G, Seila White AC, Pang B, Charisse K, Meyers R, Manoharan M, Elbashir SM.

RNA. 2012 Mar;18(3):557-68. doi: 10.1261/rna.031120.111. Epub 2012 Jan 31.

14.

NT69L, a novel analgesic, shows synergy with morphine.

Boules M, Shaw A, Liang Y, Barbut D, Richelson E.

Brain Res. 2009 Oct 19;1294:22-8. doi: 10.1016/j.brainres.2009.07.086. Epub 2009 Aug 3.

PMID:
19651107
15.

Dicer-labile PEG conjugates for siRNA delivery.

Kow SC, McCarroll J, Valade D, Boyer C, Dwarte T, Davis TP, Kavallaris M, Bulmus V.

Biomacromolecules. 2011 Dec 12;12(12):4301-10. doi: 10.1021/bm201199c. Epub 2011 Nov 21.

PMID:
22053777
16.

NTS1 and NTS2 mediate analgesia following neurotensin analog treatment in a mouse model for visceral pain.

Smith KE, Boules M, Williams K, Richelson E.

Behav Brain Res. 2012 Jun 15;232(1):93-7. doi: 10.1016/j.bbr.2012.03.044. Epub 2012 Apr 5.

PMID:
22504145
17.

The amide linker in nonpeptide neurotensin receptor ligands plays a key role in calcium signaling at the neurotensin receptor type 2.

Thomas JB, Giddings AM, Olepu S, Wiethe RW, Warner KR, Sarret P, Longpre JM, Runyon SP, Gilmour BP.

Bioorg Med Chem Lett. 2015;25(10):2060-4. doi: 10.1016/j.bmcl.2015.03.083. Epub 2015 Apr 3.

18.

Targeting neurotensin receptors with agonists and antagonists for therapeutic purposes.

Kitabgi P.

Curr Opin Drug Discov Devel. 2002 Sep;5(5):764-76. Review.

PMID:
12630297
19.

Identification of 2-({[1-(4-Fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricyclo[3.3.1.13,7]decane-2-carboxylic Acid (NTRC-844) as a Selective Antagonist for the Rat Neurotensin Receptor Type 2.

Thomas JB, Vivancos M, Giddings AM, Wiethe RW, Warner KR, Murza A, Besserer-Offroy É, Longpré JM, Runyon SP, Decker AM, Gilmour BP, Sarret P.

ACS Chem Neurosci. 2016 Sep 21;7(9):1225-31. doi: 10.1021/acschemneuro.6b00097. Epub 2016 Jul 13.

PMID:
27359371
20.

Involvement of NTS2 receptors in stress-induced analgesia.

Lafrance M, Roussy G, Belleville K, Maeno H, Beaudet N, Wada K, Sarret P.

Neuroscience. 2010 Mar 17;166(2):639-52. doi: 10.1016/j.neuroscience.2009.12.042. Epub 2009 Dec 24.

PMID:
20035838

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