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Items: 1 to 20 of 97

1.

Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells.

Greenblatt DY, Cayo MA, Adler JT, Ning L, Haymart MR, Kunnimalaiyaan M, Chen H.

Ann Surg. 2008 Jun;247(6):1036-40. doi: 10.1097/SLA.0b013e3181758d0e.

2.

Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells.

Ning L, Greenblatt DY, Kunnimalaiyaan M, Chen H.

Oncologist. 2008 Feb;13(2):98-104. doi: 10.1634/theoncologist.2007-0190.

3.

Valproic acid induces Notch1 signaling in small cell lung cancer cells.

Platta CS, Greenblatt DY, Kunnimalaiyaan M, Chen H.

J Surg Res. 2008 Jul;148(1):31-7. doi: 10.1016/j.jss.2008.03.008. Epub 2008 Apr 10.

4.

Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma.

Ning L, Jaskula-Sztul R, Kunnimalaiyaan M, Chen H.

Ann Surg Oncol. 2008 Sep;15(9):2600-5. doi: 10.1245/s10434-008-0006-z. Epub 2008 Jun 18.

5.

Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer.

Truong M, Cook MR, Pinchot SN, Kunnimalaiyaan M, Chen H.

Ann Surg Oncol. 2011 May;18(5):1506-11. doi: 10.1245/s10434-010-1488-z. Epub 2010 Dec 24.

6.

Leflunomide suppresses growth in human medullary thyroid cancer cells.

Alhefdhi A, Burke JF, Redlich A, Kunnimalaiyaan M, Chen H.

J Surg Res. 2013 Nov;185(1):212-6. doi: 10.1016/j.jss.2013.05.089. Epub 2013 Jun 19.

7.

Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells.

Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H.

J Biol Chem. 2006 Dec 29;281(52):39819-30. Epub 2006 Nov 7.

8.

MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition.

Burke JF, Schlosser L, Harrison AD, Kunnimalaiyaan M, Chen H.

Ann Surg Oncol. 2013 Nov;20(12):3862-8. doi: 10.1245/s10434-013-3168-2. Epub 2013 Jul 31.

9.

Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride.

Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H.

J Surg Res. 2010 Apr;159(2):640-4. doi: 10.1016/j.jss.2008.08.004. Epub 2008 Sep 4.

10.

Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells.

Greenblatt DY, Vaccaro AM, Jaskula-Sztul R, Ning L, Haymart M, Kunnimalaiyaan M, Chen H.

Oncologist. 2007 Aug;12(8):942-51.

11.

Expression of the active Notch1 decreases MTC tumor growth in vivo.

Jaskula-Sztul R, Pisarnturakit P, Landowski M, Chen H, Kunnimalaiyaan M.

J Surg Res. 2011 Nov;171(1):23-7. doi: 10.1016/j.jss.2011.03.035. Epub 2011 Apr 13.

12.

Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002.

Kunnimalaiyaan M, Ndiaye M, Chen H.

Surgery. 2006 Dec;140(6):1009-14; discussion 1014-5. Epub 2006 Nov 1.

PMID:
17188151
13.

Hesperetin activates the Notch1 signaling cascade, causes apoptosis, and induces cellular differentiation in anaplastic thyroid cancer.

Patel PN, Yu XM, Jaskula-Sztul R, Chen H.

Ann Surg Oncol. 2014 Dec;21 Suppl 4:S497-504. doi: 10.1245/s10434-013-3459-7. Epub 2014 Jan 14.

14.

Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivo.

Yu XM, Phan T, Patel PN, Jaskula-Sztul R, Chen H.

Cancer. 2013 Feb 15;119(4):774-81. doi: 10.1002/cncr.27742. Epub 2012 Sep 18.

15.

Induction of apoptosis and autophagy in metastatic thyroid cancer cells by valproic acid (VPA).

Xu Y, Xu D, Zhu SJ, Ye B, Dong JD, Zhang YL, Zhang Y.

Int J Clin Exp Pathol. 2015 Jul 1;8(7):8291-7. eCollection 2015 Jul 1.

16.

Valproic acid sensitizes TRAIL-resistant anaplastic thyroid carcinoma cells to apoptotic cell death.

Cha HY, Lee BS, Kang S, Shin YS, Chang JW, Sung ES, Kim YS, Choi JW, Kim JH, Kim CH.

Ann Surg Oncol. 2013 Dec;20 Suppl 3:S716-24. doi: 10.1245/s10434-013-3232-y. Epub 2013 Aug 28.

PMID:
23982257
17.

A pilot phase II study of valproic acid for treatment of low-grade neuroendocrine carcinoma.

Mohammed TA, Holen KD, Jaskula-Sztul R, Mulkerin D, Lubner SJ, Schelman WR, Eickhoff J, Chen H, Loconte NK.

Oncologist. 2011;16(6):835-43. doi: 10.1634/theoncologist.2011-0031. Epub 2011 May 31.

18.

Histone deacetylase inhibitors upregulate Notch-1 and inhibit growth in pheochromocytoma cells.

Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H.

Surgery. 2008 Dec;144(6):956-61; discussion 961-2. doi: 10.1016/j.surg.2008.08.027.

19.

Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and suppresses cell growth.

Yu XM, Jaskula-Sztul R, Ahmed K, Harrison AD, Kunnimalaiyaan M, Chen H.

Mol Cancer Ther. 2013 Jul;12(7):1276-87. doi: 10.1158/1535-7163.MCT-12-0841. Epub 2013 Apr 17.

20.

The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells.

Kushchayeva Y, Jensen K, Recupero A, Costello J, Patel A, Klubo-Gwiezdzinska J, Boyle L, Burman K, Vasko V.

J Clin Endocrinol Metab. 2014 May;99(5):E734-45. doi: 10.1210/jc.2013-3369. Epub 2014 Jan 31.

PMID:
24483157

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