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Items: 1 to 20 of 174

1.

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A, Takeda K, Ichijo H.

Genes Dev. 2008 Jun 1;22(11):1451-64. doi: 10.1101/gad.1640108.

2.

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.

Turner BJ, Talbot K.

Prog Neurobiol. 2008 May;85(1):94-134. doi: 10.1016/j.pneurobio.2008.01.001. Epub 2008 Jan 16. Review.

PMID:
18282652
3.

The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases.

Sekine Y, Takeda K, Ichijo H.

Curr Mol Med. 2006 Feb;6(1):87-97. Review.

PMID:
16472116
4.

CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations.

Jaarsma D, Rognoni F, van Duijn W, Verspaget HW, Haasdijk ED, Holstege JC.

Acta Neuropathol. 2001 Oct;102(4):293-305.

PMID:
11603803
5.

Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells.

Oh YK, Shin KS, Yuan J, Kang SJ.

J Neurochem. 2008 Feb;104(4):993-1005. doi: 10.1111/j.1471-4159.2007.05053.x.

6.

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.

Fujisawa T, Homma K, Yamaguchi N, Kadowaki H, Tsuburaya N, Naguro I, Matsuzawa A, Takeda K, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Ichijo H.

Ann Neurol. 2012 Nov;72(5):739-49. doi: 10.1002/ana.23668.

PMID:
23280792
7.

A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants.

Fujisawa T, Yamaguchi N, Kadowaki H, Tsukamoto Y, Tsuburaya N, Tsubota A, Takahashi H, Naguro I, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Homma K, Ichijo H.

Neurobiol Dis. 2015 Oct;82:478-86. doi: 10.1016/j.nbd.2015.08.010. Epub 2015 Aug 18.

PMID:
26297318
8.

Derlin-1 overexpression ameliorates mutant SOD1-induced endoplasmic reticulum stress by reducing mutant SOD1 accumulation.

Mori A, Yamashita S, Uchino K, Suga T, Ikeda T, Takamatsu K, Ishizaki M, Koide T, Kimura E, Mita S, Maeda Y, Hirano T, Uchino M.

Neurochem Int. 2011 Feb;58(3):344-53. doi: 10.1016/j.neuint.2010.12.010. Epub 2010 Dec 23.

PMID:
21185345
9.

[Molecular mechanisms of ALS-linked mutant SOD1-induced motor neuron death].

Nishitoh H, Ichijo H.

Tanpakushitsu Kakusan Koso. 2009 Mar;54(3):237-44. Review. Japanese. No abstract available.

PMID:
19288861
10.

Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease.

Bruijn LI, Cleveland DW.

Neuropathol Appl Neurobiol. 1996 Oct;22(5):373-87. Review.

PMID:
8930947
11.

ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

Suzuki H, Kanekura K, Levine TP, Kohno K, Olkkonen VM, Aiso S, Matsuoka M.

J Neurochem. 2009 Feb;108(4):973-985. doi: 10.1111/j.0022-3042.2008.05857.x.

12.

Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis.

Gomes C, Keller S, Altevogt P, Costa J.

Neurosci Lett. 2007 Nov 20;428(1):43-6. Epub 2007 Sep 20.

PMID:
17942226
13.

Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis.

Jeong SY, Rathore KI, Schulz K, Ponka P, Arosio P, David S.

J Neurosci. 2009 Jan 21;29(3):610-9. doi: 10.1523/JNEUROSCI.5443-08.2009.

14.

Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice.

Holasek SS, Wengenack TM, Kandimalla KK, Montano C, Gregor DM, Curran GL, Poduslo JF.

Brain Res. 2005 May 31;1045(1-2):185-98. Epub 2005 Apr 25.

PMID:
15910777
15.

Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells.

Sundaramoorthy V, Walker AK, Yerbury J, Soo KY, Farg MA, Hoang V, Zeineddine R, Spencer D, Atkin JD.

Cell Mol Life Sci. 2013 Nov;70(21):4181-95. doi: 10.1007/s00018-013-1385-2. Epub 2013 Jun 14.

PMID:
23765103
16.
17.

Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease.

Cleveland DW, Bruijn LI, Wong PC, Marszalek JR, Vechio JD, Lee MK, Xu XS, Borchelt DR, Sisodia SS, Price DL.

Neurology. 1996 Oct;47(4 Suppl 2):S54-61; discussion S61-2. Review.

PMID:
8858052
18.

Defective neurite outgrowth in aphidicolin/cAMP-induced motor neurons expressing mutant Cu/Zn superoxide dismutase.

Lee KW, Kim HJ, Sung JJ, Park KS, Kim M.

Int J Dev Neurosci. 2002 Oct;20(6):521-6.

PMID:
12392756
19.

AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway.

Langou K, Moumen A, Pellegrino C, Aebischer J, Medina I, Aebischer P, Raoul C.

J Neurochem. 2010 Aug;114(3):795-809. doi: 10.1111/j.1471-4159.2010.06806.x. Epub 2010 May 8.

20.

Gender difference in levels of Cu/Zn superoxide dismutase (SOD1) in cerebrospinal fluid of patients with amyotrophic lateral sclerosis.

Frutiger K, Lukas TJ, Gorrie G, Ajroud-Driss S, Siddique T.

Amyotroph Lateral Scler. 2008 Jun;9(3):184-7. doi: 10.1080/17482960801984358.

PMID:
18574763

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