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Items: 1 to 20 of 110

1.

The multi-tasking P-TEFb complex.

Brès V, Yoh SM, Jones KA.

Curr Opin Cell Biol. 2008 Jun;20(3):334-40. doi: 10.1016/j.ceb.2008.04.008. Epub 2008 May 29. Review.

2.
3.

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation.

Yoh SM, Lucas JS, Jones KA.

Genes Dev. 2008 Dec 15;22(24):3422-34. doi: 10.1101/gad.1720008.

4.

The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export.

Yoh SM, Cho H, Pickle L, Evans RM, Jones KA.

Genes Dev. 2007 Jan 15;21(2):160-74.

5.
6.

Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.

Zhou M, Huang K, Jung KJ, Cho WK, Klase Z, Kashanchi F, Pise-Masison CA, Brady JN.

J Virol. 2009 Jan;83(2):1036-44. doi: 10.1128/JVI.01316-08. Epub 2008 Oct 29.

7.

Histone cross-talk connects protein phosphatase 1α (PP1α) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression.

Hu X, Lu X, Liu R, Ai N, Cao Z, Li Y, Liu J, Yu B, Liu K, Wang H, Zhou C, Wang Y, Han A, Ding F, Chen R.

J Biol Chem. 2014 Aug 15;289(33):23154-67. doi: 10.1074/jbc.M114.570812. Epub 2014 Jun 17.

8.

Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.

Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM.

J Biol Chem. 2012 Oct 19;287(43):36609-16. doi: 10.1074/jbc.M112.410746. Epub 2012 Sep 5. Erratum in: J Biol Chem. 2013 Apr 26;288(17):12214.

9.

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription.

Dey A, Nishiyama A, Karpova T, McNally J, Ozato K.

Mol Biol Cell. 2009 Dec;20(23):4899-909. doi: 10.1091/mbc.E09-05-0380. Epub 2009 Oct 7.

10.

A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.

Sansó M, Lee KM, Viladevall L, Jacques PÉ, Pagé V, Nagy S, Racine A, St Amour CV, Zhang C, Shokat KM, Schwer B, Robert F, Fisher RP, Tanny JC.

PLoS Genet. 2012;8(8):e1002822. doi: 10.1371/journal.pgen.1002822. Epub 2012 Aug 2.

11.

BRD4 coordinates recruitment of pause release factor P-TEFb and the pausing complex NELF/DSIF to regulate transcription elongation of interferon-stimulated genes.

Patel MC, Debrosse M, Smith M, Dey A, Huynh W, Sarai N, Heightman TD, Tamura T, Ozato K.

Mol Cell Biol. 2013 Jun;33(12):2497-507. doi: 10.1128/MCB.01180-12. Epub 2013 Apr 15.

12.

Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription.

Zhou M, Deng L, Lacoste V, Park HU, Pumfery A, Kashanchi F, Brady JN, Kumar A.

J Virol. 2004 Dec;78(24):13522-33.

13.

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

Jang MK, Mochizuki K, Zhou M, Jeong HS, Brady JN, Ozato K.

Mol Cell. 2005 Aug 19;19(4):523-34.

14.

Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M.

J Biol Chem. 2012 Jan 6;287(2):1090-9. doi: 10.1074/jbc.M111.282855. Epub 2011 Nov 14.

15.

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.

Gomes NP, Bjerke G, Llorente B, Szostek SA, Emerson BM, Espinosa JM.

Genes Dev. 2006 Mar 1;20(5):601-12.

16.

P-TEFb is a crucial co-factor for Myc transactivation.

Gargano B, Amente S, Majello B, Lania L.

Cell Cycle. 2007 Aug 15;6(16):2031-7. Epub 2007 Jun 5.

PMID:
17700062
17.
18.

SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation.

Brès V, Yoshida T, Pickle L, Jones KA.

Mol Cell. 2009 Oct 9;36(1):75-87. doi: 10.1016/j.molcel.2009.08.015.

19.

Brd4 activates P-TEFb for RNA polymerase II CTD phosphorylation.

Itzen F, Greifenberg AK, Bösken CA, Geyer M.

Nucleic Acids Res. 2014 Jul;42(12):7577-90. doi: 10.1093/nar/gku449. Epub 2014 May 23.

20.

Human T-lymphotropic virus type 1 Tax protein complexes with P-TEFb and competes for Brd4 and 7SK snRNP/HEXIM1 binding.

Cho WK, Jang MK, Huang K, Pise-Masison CA, Brady JN.

J Virol. 2010 Dec;84(24):12801-9. doi: 10.1128/JVI.00943-10. Epub 2010 Oct 6.

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