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Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.

Frescas D, Pagano M.

Nat Rev Cancer. 2008 Jun;8(6):438-49. doi: 10.1038/nrc2396. Review.


Regulation of the cell cycle by SCF-type ubiquitin ligases.

Nakayama KI, Nakayama K.

Semin Cell Dev Biol. 2005 Jun;16(3):323-33. Review.


SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4.

Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer-Romero P, Glass S, Parsons T, Copeland RA, Auger KR, Benfield P, Brizuela L, Rolfe M.

Oncogene. 2000 Jul 20;19(31):3529-36.


The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro.

Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW.

Genes Dev. 1999 Feb 1;13(3):270-83. Erratum in: Genes Dev 1999 Apr 15;13(8):1050.


Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization.

Bashir T, Pagan JK, Busino L, Pagano M.

Cell Cycle. 2010 Mar 1;9(5):971-4. Epub 2010 Mar 9.


Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.

Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M.

Nature. 2004 Mar 11;428(6979):190-3.


Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.

Bornstein G, Ganoth D, Hershko A.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11515-20. Epub 2006 Jul 21.


A novel mechanism by which thiazolidinediones facilitate the proteasomal degradation of cyclin D1 in cancer cells.

Wei S, Yang HC, Chuang HC, Yang J, Kulp SK, Lu PJ, Lai MD, Chen CS.

J Biol Chem. 2008 Sep 26;283(39):26759-70. doi: 10.1074/jbc.M802160200. Epub 2008 Jul 23.


Triggering ubiquitination of a CDK inhibitor at origins of DNA replication.

Furstenthal L, Swanson C, Kaiser BK, Eldridge AG, Jackson PK.

Nat Cell Biol. 2001 Aug;3(8):715-22.


SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.

Shirogane T, Jin J, Ang XL, Harper JW.

J Biol Chem. 2005 Jul 22;280(29):26863-72. Epub 2005 May 24.


Involvement of two distinct ubiquitin E3 ligase systems for p27 degradation in corneal endothelial cells.

Lee JG, Kay EP.

Invest Ophthalmol Vis Sci. 2008 Jan;49(1):189-96. doi: 10.1167/iovs.07-0855.


Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.

Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr.

Nature. 2004 Mar 11;428(6979):194-8.


Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.

Nakayama K, Nagahama H, Minamishima YA, Matsumoto M, Nakamichi I, Kitagawa K, Shirane M, Tsunematsu R, Tsukiyama T, Ishida N, Kitagawa M, Nakayama K, Hatakeyama S.

EMBO J. 2000 May 2;19(9):2069-81.


The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest.

Isoda M, Kanemori Y, Nakajo N, Uchida S, Yamashita K, Ueno H, Sagata N.

Mol Biol Cell. 2009 Apr;20(8):2186-95. doi: 10.1091/mbc.E09-01-0008. Epub 2009 Feb 25.


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