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Items: 1 to 20 of 136

1.

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.

Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, Wyss-Coray T.

J Clin Invest. 2008 Jun;118(6):2190-9. doi: 10.1172/JCI33585.

2.

Regulation of Abeta pathology by beclin 1: a protective role for autophagy?

Lee JA, Gao FB.

J Clin Invest. 2008 Jun;118(6):2015-8. doi: 10.1172/JCI35662.

3.

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M.

Prog Neurobiol. 2013 Jul-Aug;106-107:33-54. doi: 10.1016/j.pneurobio.2013.06.002. Epub 2013 Jul 1. Review.

PMID:
23827971
4.

Regulation of amyloid precursor protein processing by the Beclin 1 complex.

Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, Wyss-Coray T.

PLoS One. 2010 Jun 15;5(6):e11102. doi: 10.1371/journal.pone.0011102.

5.

Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models.

Shin JY, Park HJ, Kim HN, Oh SH, Bae JS, Ha HJ, Lee PH.

Autophagy. 2014 Jan;10(1):32-44. doi: 10.4161/auto.26508. Epub 2013 Jan 1.

6.

Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy.

Joshi G, Gan KA, Johnson DA, Johnson JA.

Neurobiol Aging. 2015 Feb;36(2):664-79. doi: 10.1016/j.neurobiolaging.2014.09.004. Epub 2014 Sep 6.

7.

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models.

Khandelwal PJ, Herman AM, Hoe HS, Rebeck GW, Moussa CE.

Hum Mol Genet. 2011 Jun 1;20(11):2091-102. doi: 10.1093/hmg/ddr091. Epub 2011 Mar 4.

8.

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice.

Wang C, Zhang X, Teng Z, Zhang T, Li Y.

Eur J Pharmacol. 2014 Oct 5;740:312-20. doi: 10.1016/j.ejphar.2014.06.051. Epub 2014 Jul 17.

PMID:
25041840
9.

Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells.

Lee HR, Shin HK, Park SY, Kim HY, Bae SS, Lee WS, Rhim BY, Hong KW, Kim CD.

PLoS One. 2015 Aug 5;10(8):e0134486. doi: 10.1371/journal.pone.0134486. eCollection 2015.

10.

Haplodeficiency of Cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice.

Cheng S, Wani WY, Hottman DA, Jeong A, Cao D, LeBlanc KJ, Saftig P, Zhang J, Li L.

J Neurochem. 2017 Jul;142(2):297-304. doi: 10.1111/jnc.14048. Epub 2017 May 26.

PMID:
28429406
11.

APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.

Maulik M, Peake K, Chung J, Wang Y, Vance JE, Kar S.

Hum Mol Genet. 2015 Dec 15;24(24):7132-50. doi: 10.1093/hmg/ddv413. Epub 2015 Oct 3.

12.

Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons.

Yang GZ, Yang M, Lim Y, Lu JJ, Wang TH, Qi JG, Zhong JH, Zhou XF.

J Neurochem. 2012 Sep;122(5):1010-22. doi: 10.1111/j.1471-4159.2012.07845.x.

13.

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.

Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KMA, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M.

Neurobiol Dis. 2016 Jan;85:187-205. doi: 10.1016/j.nbd.2015.11.005. Epub 2015 Nov 10.

PMID:
26563932
14.

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease.

Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B, Vassar R, He C.

PLoS Genet. 2017 Aug 14;13(8):e1006962. doi: 10.1371/journal.pgen.1006962. eCollection 2017 Aug.

15.

Sphingolipid storage impairs autophagic clearance of Alzheimer-associated proteins.

Tamboli IY, Tien NT, Walter J.

Autophagy. 2011 Jun;7(6):645-6. Epub 2011 Jun 1.

PMID:
21460623
16.

Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.

Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R.

PLoS One. 2014 Jul 3;9(7):e101643. doi: 10.1371/journal.pone.0101643. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e110914.

17.

Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis.

Guglielmotto M, Monteleone D, Piras A, Valsecchi V, Tropiano M, Ariano S, Fornaro M, Vercelli A, Puyal J, Arancio O, Tabaton M, Tamagno E.

Autophagy. 2014 Oct 1;10(10):1827-43. doi: 10.4161/auto.30001. Epub 2014 Aug 12.

18.

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA.

Brain. 2011 Jan;134(Pt 1):258-77. doi: 10.1093/brain/awq341.

19.

The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice.

Rijal Upadhaya A, Scheibe F, Kosterin I, Abramowski D, Gerth J, Kumar S, Liebau S, Yamaguchi H, Walter J, Staufenbiel M, Thal DR.

Acta Neuropathol Commun. 2013 Nov 18;1:77. doi: 10.1186/2051-5960-1-77.

20.

[Alzheimer disease: cellular and molecular aspects].

Octave JN.

Bull Mem Acad R Med Belg. 2005;160(10-12):445-9; discussion 450-1. French.

PMID:
16768248

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