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Items: 1 to 20 of 132

1.

Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator.

Luo L, Carson JD, Molnar KS, Tuske SJ, Coales SJ, Hamuro Y, Sung CM, Sudakin V, Auger KR, Dhanak D, Jackson JR, Huang PS, Tummino PJ, Copeland RA.

J Am Chem Soc. 2008 Jun 18;130(24):7584-91. doi: 10.1021/ja710889h. Epub 2008 May 21.

PMID:
18491908
2.

Mechanism of inhibition of human KSP by ispinesib.

Lad L, Luo L, Carson JD, Wood KW, Hartman JJ, Copeland RA, Sakowicz R.

Biochemistry. 2008 Mar 18;47(11):3576-85. doi: 10.1021/bi702061g. Epub 2008 Feb 22.

PMID:
18290633
3.

Mechanism of inhibition of human KSP by monastrol: insights from kinetic analysis and the effect of ionic strength on KSP inhibition.

Luo L, Carson JD, Dhanak D, Jackson JR, Huang PS, Lee Y, Sakowicz R, Copeland RA.

Biochemistry. 2004 Dec 7;43(48):15258-66.

PMID:
15568818
4.

Monastrol inhibition of the mitotic kinesin Eg5.

Cochran JC, Gatial JE 3rd, Kapoor TM, Gilbert SP.

J Biol Chem. 2005 Apr 1;280(13):12658-67. Epub 2005 Jan 23.

5.

Kinesin-5: cross-bridging mechanism to targeted clinical therapy.

Wojcik EJ, Buckley RS, Richard J, Liu L, Huckaba TM, Kim S.

Gene. 2013 Dec 1;531(2):133-49. doi: 10.1016/j.gene.2013.08.004. Epub 2013 Aug 14. Review.

6.

NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding site.

Learman SS, Kim CD, Stevens NS, Kim S, Wojcik EJ, Walker RA.

Biochemistry. 2009 Mar 3;48(8):1754-62. doi: 10.1021/bi801291q.

7.

Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.

Rickert KW, Schaber M, Torrent M, Neilson LA, Tasber ES, Garbaccio R, Coleman PJ, Harvey D, Zhang Y, Yang Y, Marshall G, Lee L, Walsh ES, Hamilton K, Buser CA.

Arch Biochem Biophys. 2008 Jan 15;469(2):220-31. Epub 2007 Nov 1.

PMID:
17999913
8.

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

Luo L, Parrish CA, Nevins N, McNulty DE, Chaudhari AM, Carson JD, Sudakin V, Shaw AN, Lehr R, Zhao H, Sweitzer S, Lad L, Wood KW, Sakowicz R, Annan RS, Huang PS, Jackson JR, Dhanak D, Copeland RA, Auger KR.

Nat Chem Biol. 2007 Nov;3(11):722-6. Epub 2007 Oct 7.

PMID:
17922005
9.

Antitumor activity of a kinesin inhibitor.

Sakowicz R, Finer JT, Beraud C, Crompton A, Lewis E, Fritsch A, Lee Y, Mak J, Moody R, Turincio R, Chabala JC, Gonzales P, Roth S, Weitman S, Wood KW.

Cancer Res. 2004 May 1;64(9):3276-80.

10.

Thermodynamics of nucleotide and inhibitor binding to wild-type and ispinesib-resistant forms of human kinesin spindle protein.

Sheth PR, Basso A, Duca JS, Lesburg CA, Ogas P, Gray K, Nale L, Mannarino AF, Prongay AJ, Le HV.

Biochemistry. 2009 Nov 24;48(46):11045-55. doi: 10.1021/bi900946r.

PMID:
19824700
11.

Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage.

Tao W, South VJ, Zhang Y, Davide JP, Farrell L, Kohl NE, Sepp-Lorenzino L, Lobell RB.

Cancer Cell. 2005 Jul;8(1):49-59.

12.

Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.

Cox CD, Breslin MJ, Mariano BJ, Coleman PJ, Buser CA, Walsh ES, Hamilton K, Huber HE, Kohl NE, Torrent M, Yan Y, Kuo LC, Hartman GD.

Bioorg Med Chem Lett. 2005 Apr 15;15(8):2041-5.

PMID:
15808464
13.
14.

Pathway of ATP hydrolysis by monomeric kinesin Eg5.

Cochran JC, Krzysiak TC, Gilbert SP.

Biochemistry. 2006 Oct 10;45(40):12334-44.

15.

Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors.

Matsuno K, Sawada J, Sugimoto M, Ogo N, Asai A.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61. doi: 10.1016/j.bmcl.2009.01.018. Epub 2009 Jan 11.

PMID:
19167222
16.

Novel ATP-competitive kinesin spindle protein inhibitors.

Parrish CA, Adams ND, Auger KR, Burgess JL, Carson JD, Chaudhari AM, Copeland RA, Diamond MA, Donatelli CA, Duffy KJ, Faucette LF, Finer JT, Huffman WF, Hugger ED, Jackson JR, Knight SD, Luo L, Moore ML, Newlander KA, Ridgers LH, Sakowicz R, Shaw AN, Sung CM, Sutton D, Wood KW, Zhang SY, Zimmerman MN, Dhanak D.

J Med Chem. 2007 Oct 4;50(20):4939-52. Epub 2007 Aug 29.

PMID:
17725339
17.

Mechanistic analysis of the mitotic kinesin Eg5.

Cochran JC, Sontag CA, Maliga Z, Kapoor TM, Correia JJ, Gilbert SP.

J Biol Chem. 2004 Sep 10;279(37):38861-70. Epub 2004 Jul 6.

18.
19.

Modulation of the kinesin ATPase cycle by neck linker docking and microtubule binding.

Zhao YC, Kull FJ, Cochran JC.

J Biol Chem. 2010 Aug 13;285(33):25213-20. doi: 10.1074/jbc.M110.123067. Epub 2010 Jun 17.

20.

Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.

Oishi S, Watanabe T, Sawada J, Asai A, Ohno H, Fujii N.

J Med Chem. 2010 Jul 8;53(13):5054-8. doi: 10.1021/jm100476d.

PMID:
20521839

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