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Items: 1 to 20 of 98


Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks.

Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R.

Cell. 2008 May 16;133(4):666-80. doi: 10.1016/j.cell.2008.04.025.


Giving space to cell signaling.

Kholodenko BN, Kolch W.

Cell. 2008 May 16;133(4):566-7. doi: 10.1016/j.cell.2008.04.033.


Spatial modeling of cell signaling networks.

Cowan AE, Moraru II, Schaff JC, Slepchenko BM, Loew LM.

Methods Cell Biol. 2012;110:195-221. doi: 10.1016/B978-0-12-388403-9.00008-4.


Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy.

Perera RK, Sprenger JU, Steinbrecher JH, Hübscher D, Lehnart SE, Abesser M, Schuh K, El-Armouche A, Nikolaev VO.

Circ Res. 2015 Apr 10;116(8):1304-11. doi: 10.1161/CIRCRESAHA.116.306082. Epub 2015 Feb 16.


PDE4B mediates local feedback regulation of β₁-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes.

Mika D, Richter W, Westenbroek RE, Catterall WA, Conti M.

J Cell Sci. 2014 Mar 1;127(Pt 5):1033-42. doi: 10.1242/jcs.140251. Epub 2014 Jan 10.


beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics.

Violin JD, DiPilato LM, Yildirim N, Elston TC, Zhang J, Lefkowitz RJ.

J Biol Chem. 2008 Feb 1;283(5):2949-61. Epub 2007 Nov 28.


A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes.

Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK.

J Biol Chem. 2014 May 23;289(21):14771-81. doi: 10.1074/jbc.M113.542589. Epub 2014 Apr 8.


Models of spatially restricted biochemical reaction systems.

Neves SR, Iyengar R.

J Biol Chem. 2009 Feb 27;284(9):5445-9. doi: 10.1074/jbc.R800058200. Epub 2008 Oct 20. Review.


Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.

Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, Bos JL.

J Cell Biol. 2003 Feb 17;160(4):487-93. Epub 2003 Feb 10.


Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway.

Zhao CY, Greenstein JL, Winslow RL.

J Mol Cell Cardiol. 2015 Nov;88:29-38. doi: 10.1016/j.yjmcc.2015.09.011. Epub 2015 Sep 23.


Mitochondrial disruption occurs downstream from β-adrenergic overactivation by isoproterenol in differentiated, but not undifferentiated H9c2 cardiomyoblasts: differential activation of stress and survival pathways.

Branco AF, Sampaio SF, Wieckowski MR, Sardão VA, Oliveira PJ.

Int J Biochem Cell Biol. 2013 Nov;45(11):2379-91. doi: 10.1016/j.biocel.2013.08.006. Epub 2013 Aug 16.


Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling.

Xin W, Tran TM, Richter W, Clark RB, Rich TC.

J Gen Physiol. 2008 Apr;131(4):349-64. doi: 10.1085/jgp.200709881. Epub 2008 Mar 17.


Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R.

Muller M, Obeyesekere M, Mills GB, Ram PT.

FASEB J. 2008 May;22(5):1393-403. doi: 10.1096/fj.07-9100com. Epub 2008 Jan 2.


The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations.

Oliveira RF, Terrin A, Di Benedetto G, Cannon RC, Koh W, Kim M, Zaccolo M, Blackwell KT.

PLoS One. 2010 Jul 22;5(7):e11725. doi: 10.1371/journal.pone.0011725.


Reciprocal regulation of PKA and Rac signaling.

Bachmann VA, Riml A, Huber RG, Baillie GS, Liedl KR, Valovka T, Stefan E.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8531-6. doi: 10.1073/pnas.1215902110. Epub 2013 May 8.


The mAKAP signaling complex: integration of cAMP, calcium, and MAP kinase signaling pathways.

Dodge-Kafka KL, Kapiloff MS.

Eur J Cell Biol. 2006 Jul;85(7):593-602. Epub 2006 Feb 7. Review.


Synaptic activity induces signalling to CREB without increasing global levels of cAMP in hippocampal neurons.

Pokorska A, Vanhoutte P, Arnold FJ, Silvagno F, Hardingham GE, Bading H.

J Neurochem. 2003 Feb;84(3):447-52.


Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation.

Wangorsch G, Butt E, Mark R, Hubertus K, Geiger J, Dandekar T, Dittrich M.

BMC Syst Biol. 2011 Oct 28;5:178. doi: 10.1186/1752-0509-5-178.

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