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Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells.

Wang X, Chen W, Zeng W, Bai L, Tesfaigzi Y, Belinsky SA, Lin Y.

Mol Cancer Ther. 2008 May;7(5):1156-63. doi: 10.1158/1535-7163.MCT-07-2183.


Bcl-2 family proteins contribute to apoptotic resistance in lung cancer multicellular spheroids.

Yang TM, Barbone D, Fennell DA, Broaddus VC.

Am J Respir Cell Mol Biol. 2009 Jul;41(1):14-23. doi: 10.1165/rcmb.2008-0320OC. Epub 2008 Dec 18.


ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis.

Song JH, Kandasamy K, Kraft AS.

J Biol Chem. 2008 Sep 5;283(36):25003-13. doi: 10.1074/jbc.M802511200. Epub 2008 Jul 3.


Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.

Taniai M, Grambihler A, Higuchi H, Werneburg N, Bronk SF, Farrugia DJ, Kaufmann SH, Gores GJ.

Cancer Res. 2004 May 15;64(10):3517-24.


Compound C sensitizes Caki renal cancer cells to TRAIL-induced apoptosis through reactive oxygen species-mediated down-regulation of c-FLIPL and Mcl-1.

Jang JH, Lee TJ, Yang ES, Min do S, Kim YH, Kim SH, Choi YH, Park JW, Choi KS, Kwon TK.

Exp Cell Res. 2010 Aug 1;316(13):2194-203. doi: 10.1016/j.yexcr.2010.04.028. Epub 2010 May 6.


Membrane expression of DR4, DR5 and caspase-8 levels, but not Mcl-1, determine sensitivity of human myeloma cells to Apo2L/TRAIL.

Gómez-Benito M, Martinez-Lorenzo MJ, Anel A, Marzo I, Naval J.

Exp Cell Res. 2007 Jul 1;313(11):2378-88. Epub 2007 Mar 30.


Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism.

Ortiz-Ferrón G, Yerbes R, Eramo A, López-Pérez AI, De Maria R, López-Rivas A.

Cell Res. 2008 Jun;18(6):664-76. doi: 10.1038/cr.2008.54.


ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2.

Martín-Pérez R, Niwa M, López-Rivas A.

Apoptosis. 2012 Apr;17(4):349-63. doi: 10.1007/s10495-011-0673-2.


Berberine sensitizes TRAIL-induced apoptosis through proteasome-mediated downregulation of c-FLIP and Mcl-1 proteins.

Lee SJ, Noh HJ, Sung EG, Song IH, Kim JY, Kwon TK, Lee TJ.

Int J Oncol. 2011 Feb;38(2):485-92. doi: 10.3892/ijo.2010.878. Epub 2010 Dec 17.


Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis.

Chen W, Bai L, Wang X, Xu S, Belinsky SA, Lin Y.

Mol Pharmacol. 2010 Mar;77(3):416-23. doi: 10.1124/mol.109.061226. Epub 2009 Nov 23.


Imatinib enhances human melanoma cell susceptibility to TRAIL-induced cell death: Relationship to Bcl-2 family and caspase activation.

Hamaï A, Richon C, Meslin F, Faure F, Kauffmann A, Lecluse Y, Jalil A, Larue L, Avril MF, Chouaib S, Mehrpour M.

Oncogene. 2006 Dec 7;25(58):7618-34. Epub 2006 Sep 18. Erratum in: Oncogene. 2007 Feb 22;26(8):1256.


The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.

Elrod HA, Lin YD, Yue P, Wang X, Lonial S, Khuri FR, Sun SY.

Mol Cancer Ther. 2007 Jul;6(7):2029-38. Epub 2007 Jun 29.


Upregulation of c-FLIP-short in response to TRAIL promotes survival of NSCLC cells, which could be suppressed by inhibition of Ca2+/calmodulin signaling.

Kaminskyy VO, Surova OV, Piskunova T, Zborovskaya IB, Tchevkina EM, Andera L, Zhivotovsky B.

Cell Death Dis. 2013 Mar 7;4:e522. doi: 10.1038/cddis.2013.51.


Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents.

Sánchez-Pérez T, Ortiz-Ferrón G, López-Rivas A.

Cell Death Differ. 2010 May;17(5):883-94. doi: 10.1038/cdd.2009.176. Epub 2009 Nov 27.


Latent membrane protein 1 mediates the resistance of nasopharyngeal carcinoma cells to TRAIL-induced apoptosis by activation of the PI3K/Akt signaling pathway.

Li SS, Yang S, Wang S, Yang XM, Tang QL, Wang SH.

Oncol Rep. 2011 Dec;26(6):1573-9. doi: 10.3892/or.2011.1423. Epub 2011 Aug 17.


Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner.

Park EJ, Min KJ, Choi KS, Kwon TK.

Exp Cell Res. 2014 Apr 15;323(1):144-54. doi: 10.1016/j.yexcr.2014.01.009. Epub 2014 Jan 22.


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