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Acquired resistance to acetaminophen hepatotoxicity is associated with induction of multidrug resistance-associated protein 4 (Mrp4) in proliferating hepatocytes.

Aleksunes LM, Campion SN, Goedken MJ, Manautou JE.

Toxicol Sci. 2008 Aug;104(2):261-73. doi: 10.1093/toxsci/kfn093. Epub 2008 May 8.


Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury.

Aleksunes LM, Scheffer GL, Jakowski AB, Pruimboom-Brees IM, Manautou JE.

Toxicol Sci. 2006 Feb;89(2):370-9. Epub 2005 Sep 21.


Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.

Aleksunes LM, Slitt AL, Maher JM, Augustine LM, Goedken MJ, Chan JY, Cherrington NJ, Klaassen CD, Manautou JE.

Toxicol Appl Pharmacol. 2008 Jan 1;226(1):74-83. Epub 2007 Aug 31.


Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes.

Rudraiah S, Rohrer PR, Gurevich I, Goedken MJ, Rasmussen T, Hines RN, Manautou JE.

Toxicol Sci. 2014 Sep;141(1):263-77. doi: 10.1093/toxsci/kfu124. Epub 2014 Jun 27.


Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function.

Campion SN, Johnson R, Aleksunes LM, Goedken MJ, van Rooijen N, Scheffer GL, Cherrington NJ, Manautou JE.

Am J Physiol Gastrointest Liver Physiol. 2008 Aug;295(2):G294-304. doi: 10.1152/ajpgi.00541.2007. Epub 2008 Jun 12.


Type 1 diabetic mice are protected from acetaminophen hepatotoxicity.

Shankar K, Vaidya VS, Apte UM, Manautou JE, Ronis MJ, Bucci TJ, Mehendale HM.

Toxicol Sci. 2003 Jun;73(2):220-34. Epub 2003 Apr 15.


Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice.

Aibo DI, Birmingham NP, Lewandowski R, Maddox JF, Roth RA, Ganey PE, Wagner JG, Harkema JR.

Toxicol Sci. 2010 May;115(1):267-85. doi: 10.1093/toxsci/kfq034. Epub 2010 Feb 1.


Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection).

O'Connor MA, Koza-Taylor P, Campion SN, Aleksunes LM, Gu X, Enayetallah AE, Lawton MP, Manautou JE.

Toxicol Appl Pharmacol. 2014 Jan 1;274(1):156-67. doi: 10.1016/j.taap.2013.09.025. Epub 2013 Oct 11.


Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen toxicity.

Donahower BC, McCullough SS, Hennings L, Simpson PM, Stowe CD, Saad AG, Kurten RC, Hinson JA, James LP.

J Pharmacol Exp Ther. 2010 Jul;334(1):33-43. doi: 10.1124/jpet.109.163840. Epub 2010 Apr 2.


Sex difference in susceptibility to acetaminophen hepatotoxicity is reversed by buthionine sulfoximine.

Masubuchi Y, Nakayama J, Watanabe Y.

Toxicology. 2011 Sep 5;287(1-3):54-60. doi: 10.1016/j.tox.2011.05.018. Epub 2011 Jun 6.


Sulforaphane protects against acetaminophen-induced hepatotoxicity.

Noh JR, Kim YH, Hwang JH, Choi DH, Kim KS, Oh WK, Lee CH.

Food Chem Toxicol. 2015 Jun;80:193-200. doi: 10.1016/j.fct.2015.03.020. Epub 2015 Mar 25.


CHOP is a critical regulator of acetaminophen-induced hepatotoxicity.

Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, Chung RT, Tirosh B, Shibolet O.

J Hepatol. 2013 Sep;59(3):495-503. doi: 10.1016/j.jhep.2013.04.024. Epub 2013 May 9.


Influence of acetaminophen vehicle on regulation of transporter gene expression during hepatotoxicity.

Aleksunes LM, Augustine LM, Cherrington NJ, Manautou JE.

J Toxicol Environ Health A. 2007 Nov;70(21):1870-2.


Activation of autophagy protects against acetaminophen-induced hepatotoxicity.

Ni HM, Bockus A, Boggess N, Jaeschke H, Ding WX.

Hepatology. 2012 Jan;55(1):222-32. doi: 10.1002/hep.24690. Epub 2011 Dec 6.


Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.

Williams CD, Bajt ML, Farhood A, Jaeschke H.

Liver Int. 2010 Oct;30(9):1280-92. doi: 10.1111/j.1478-3231.2010.02284.x.


Novel protective mechanisms for S-adenosyl-L-methionine against acetaminophen hepatotoxicity: improvement of key antioxidant enzymatic function.

Michael Brown J, Ball JG, Wright MS, Van Meter S, Valentovic MA.

Toxicol Lett. 2012 Aug 3;212(3):320-8. doi: 10.1016/j.toxlet.2012.05.018. Epub 2012 Jun 5.


Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway.

Jiang YM, Wang Y, Tan HS, Yu T, Fan XM, Chen P, Zeng H, Huang M, Bi HC.

Acta Pharmacol Sin. 2016 Mar;37(3):382-9. doi: 10.1038/aps.2015.120. Epub 2016 Jan 25.


The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice.

Nguyen KA, Carbone JM, Silva VM, Chen C, Hennig GE, Whiteley HE, Manautou JE.

J Toxicol Environ Health A. 1999 Oct 15;58(3):171-86.


Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.

Dambach DM, Durham SK, Laskin JD, Laskin DL.

Toxicol Appl Pharmacol. 2006 Mar 1;211(2):157-65. Epub 2005 Aug 2.


Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice.

Ding Y, Li Q, Xu Y, Chen Y, Deng Y, Zhi F, Qian K.

PLoS One. 2016 May 4;11(5):e0154375. doi: 10.1371/journal.pone.0154375. eCollection 2016.

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